The Effect of Short Periods of Normobaric Hyperoxia on Cerebrospinal Oxidative Stress Markers Following A Severe Head Injury

2.50
Hdl Handle:
http://hdl.handle.net/10755/163233
Category:
Abstract
Type:
Presentation
Title:
The Effect of Short Periods of Normobaric Hyperoxia on Cerebrospinal Oxidative Stress Markers Following A Severe Head Injury
Author(s):
Puccio, Ava M.; Bayir, Hulya; Kochanek, Patrick M.; Hoffman, Leslie A.; Kim, Yookyung; Walter, Kevin A.
Author Details:
Ava M. Puccio, RN, MSN, University of Pittsburgh Medical Center, Nursing/Neurosurgery, Pittsburgh, Pennsylvania, USA, email: puccioam@upmc.edu; Hulya Bayir, MD; Patrick M. Kochanek, MD; Leslie A. Hoffman, PhD; Yookyung Kim, PhD; Kevin A. Walter
Abstract:
Purpose: The purpose of this study is to examine the effect of short periods of normobaric hyperoxia (2h) in the adult traumatic brain injured (TBI) population on cerebrospinal fluid (CSF) oxidative stress markers. Theoretical Framework: Cerebral ischemia following a severe traumatic brain injury (TBI) has been shown to worsen neurological outcome1. Many intensive care units have instituted protocols, including the use of normobaric hyperoxia, to maintain the local brain tissue oxygenation (PbtO2) > 20 mm Hg. This non-discriminate usage may increase oxidative stress following a TBI, and may place the injured brain at risk for secondary injury. Methods (Design, Sample, Setting, Measures, Analysis): CSF was assessed in adults [n=5, (4 male, 1 female), mean age 24.8 ñ 6.6 yrs], with severe TBI (average Glasgow Coma Scale score 6 ñ 1.4) pre-, during, and post-FiO2 = 1.0 challenge. Markers of lipid peroxidation (F2-isoprostane [ELISA]), protein oxidation (protein thiols [fluorescence]) and antioxidant defenses (total antioxidant reserve (AOR) [chemiluminescence] and glutathione [fluorescence]) were evaluated. Physiological parameters, [intracranial pressure (ICP), mean arterial pressure (MAP), cerebral perfusion pressure (CPP), PbtO2, arterial oxygen content (pO2)] were assessed at the same time points, with the 30 min average prior to each FiO2 change. Repeated measures ANOVA was performed for each outcome measure. Results: Results: Mean (ñSD) PbtO2 and pO2 levels significantly changed for each time point, [pre- 28.5 ~ 5.4, 169.4 ~ 67.4; during 71.7 ~ 48.7, 357.3 ~ 127.2; and post-FiO2 challenge 30.8 ~ 14.9, 181.6 ~ 14.7, (p=.04;.01), respectively]. Oxidative stress markers, antioxidant reserve defenses and physiological parameters (ICP, MAP and CPP) did not significantly change for any time period. Conclusions and Implications: These preliminary findings suggest that brief periods of normobaric hyperoxia do not produce oxidative stress. Additional studies are required to examine a larger population and extended periods of normobaric hyperoxia. 1JT 30:933, 1990.
Repository Posting Date:
27-Oct-2011
Date of Publication:
27-Oct-2011
Conference Date:
2006
Conference Name:
18th Annual Scientific Sessions
Conference Host:
Eastern Nursing Research Society
Conference Location:
Cherry Hill, New Jersey
Description:
�New Momentum for Nursing Research: Multidisciplinary Alliances�, held on April 20th -22nd at the Hilton in Cherry Hill, New Jersey
Note:
This is an abstract-only submission. If the author has submitted a full-text item based on this abstract, you may find it by browsing the Virginia Henderson Global Nursing e-Repository by author. If author contact information is available in this abstract, please feel free to contact him or her with your queries regarding this submission. Alternatively, please contact the conference host, journal, or publisher (according to the circumstance) for further details regarding this item. If a citation is listed in this record, the item has been published and is available via open-access avenues or a journal/database subscription. Contact your library for assistance in obtaining the as-published article.

Full metadata record

DC FieldValue Language
dc.type.categoryAbstracten_US
dc.typePresentationen_GB
dc.titleThe Effect of Short Periods of Normobaric Hyperoxia on Cerebrospinal Oxidative Stress Markers Following A Severe Head Injuryen_GB
dc.contributor.authorPuccio, Ava M.en_US
dc.contributor.authorBayir, Hulyaen_US
dc.contributor.authorKochanek, Patrick M.en_US
dc.contributor.authorHoffman, Leslie A.en_US
dc.contributor.authorKim, Yookyungen_US
dc.contributor.authorWalter, Kevin A.en_US
dc.author.detailsAva M. Puccio, RN, MSN, University of Pittsburgh Medical Center, Nursing/Neurosurgery, Pittsburgh, Pennsylvania, USA, email: puccioam@upmc.edu; Hulya Bayir, MD; Patrick M. Kochanek, MD; Leslie A. Hoffman, PhD; Yookyung Kim, PhD; Kevin A. Walteren_US
dc.identifier.urihttp://hdl.handle.net/10755/163233-
dc.description.abstractPurpose: The purpose of this study is to examine the effect of short periods of normobaric hyperoxia (2h) in the adult traumatic brain injured (TBI) population on cerebrospinal fluid (CSF) oxidative stress markers. Theoretical Framework: Cerebral ischemia following a severe traumatic brain injury (TBI) has been shown to worsen neurological outcome1. Many intensive care units have instituted protocols, including the use of normobaric hyperoxia, to maintain the local brain tissue oxygenation (PbtO2) > 20 mm Hg. This non-discriminate usage may increase oxidative stress following a TBI, and may place the injured brain at risk for secondary injury. Methods (Design, Sample, Setting, Measures, Analysis): CSF was assessed in adults [n=5, (4 male, 1 female), mean age 24.8 ñ 6.6 yrs], with severe TBI (average Glasgow Coma Scale score 6 ñ 1.4) pre-, during, and post-FiO2 = 1.0 challenge. Markers of lipid peroxidation (F2-isoprostane [ELISA]), protein oxidation (protein thiols [fluorescence]) and antioxidant defenses (total antioxidant reserve (AOR) [chemiluminescence] and glutathione [fluorescence]) were evaluated. Physiological parameters, [intracranial pressure (ICP), mean arterial pressure (MAP), cerebral perfusion pressure (CPP), PbtO2, arterial oxygen content (pO2)] were assessed at the same time points, with the 30 min average prior to each FiO2 change. Repeated measures ANOVA was performed for each outcome measure. Results: Results: Mean (ñSD) PbtO2 and pO2 levels significantly changed for each time point, [pre- 28.5 ~ 5.4, 169.4 ~ 67.4; during 71.7 ~ 48.7, 357.3 ~ 127.2; and post-FiO2 challenge 30.8 ~ 14.9, 181.6 ~ 14.7, (p=.04;.01), respectively]. Oxidative stress markers, antioxidant reserve defenses and physiological parameters (ICP, MAP and CPP) did not significantly change for any time period. Conclusions and Implications: These preliminary findings suggest that brief periods of normobaric hyperoxia do not produce oxidative stress. Additional studies are required to examine a larger population and extended periods of normobaric hyperoxia. 1JT 30:933, 1990.en_GB
dc.date.available2011-10-27T11:03:46Z-
dc.date.issued2011-10-27en_GB
dc.date.accessioned2011-10-27T11:03:46Z-
dc.conference.date2006en_US
dc.conference.name18th Annual Scientific Sessionsen_US
dc.conference.hostEastern Nursing Research Societyen_US
dc.conference.locationCherry Hill, New Jerseyen_US
dc.description�New Momentum for Nursing Research: Multidisciplinary Alliances�, held on April 20th -22nd at the Hilton in Cherry Hill, New Jerseyen_US
dc.description.noteThis is an abstract-only submission. If the author has submitted a full-text item based on this abstract, you may find it by browsing the Virginia Henderson Global Nursing e-Repository by author. If author contact information is available in this abstract, please feel free to contact him or her with your queries regarding this submission. Alternatively, please contact the conference host, journal, or publisher (according to the circumstance) for further details regarding this item. If a citation is listed in this record, the item has been published and is available via open-access avenues or a journal/database subscription. Contact your library for assistance in obtaining the as-published article.-
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