The relationship between cerebralspinal fluid lactate/pyruvate and cerebral blood flow following traumatic brain injury

2.50
Hdl Handle:
http://hdl.handle.net/10755/163393
Category:
Abstract
Type:
Presentation
Title:
The relationship between cerebralspinal fluid lactate/pyruvate and cerebral blood flow following traumatic brain injury
Author(s):
Chuang, Pei-Ying; Alexander, Sheila; Kim, Yookyung
Author Details:
Pei-Ying Chuang, University of Pittsburgh School of Nursing, Pittsburgh, Pennsylvania, USA, email: pec12@pitt.edu; Sheila Alexander; Yookyung Kim, Ph.D.
Abstract:
Purpose: The objective of this study was to examine the relationship between CBF and CSF L/P ratio. Theoretical Framework: Cerebral ischemia is a cause of secondary injury that increases morbidity and mortality following a traumatic brain injury (TBI). Serial Xenon computed topographic (XeCT) scanning quantifies cerebral blood flow (CBF) and identified areas of ischemia; however it is only performed periodically. During ischemia, aerobic metabolism shifts to anaerobic metabolism, resulting in increased lactate/pyruvate (L/P) ratio. It is of interest to examine the cerebralspinal fluid (CSF) L/P ratio as a predictor of ischemia in the acute phase after TBI. Methods (Design, Sample, Setting, Measures, Analysis): The sample consisted of 64 subjects with a severe TBI [Glasgow Coma Score (GCS)?8], admitted to a level I trauma center, with an extraventricular drainage catheter and XeCT performed on day 1, 3, and 5. Mean CBF was obtained by averaging the mean left and right hemispheric CBF across 4 levels. Low CBF was defined as mean CBF less than 40 ml/g/min. CSF L/P ratio was drawn an average of 1.5 (SD = 7.0) hours before XeCT. Descriptive and correlational analyses were used to examine the relationship between CSF L/P ratio and CBF. Results: : The sample had a mean age of 30.5 years old (SD= 14) and was primarily male (73 %) and Caucasian (87.5%). Mean GCS was 5.7 (SD =1.4, Mode = 7). Thirty one subjects (48.4%) exhibited low CBF. No significant relationship was shown between CSF L/P ratio and low CBF (p=.13). Low CBF was significantly associated with race (p =.02) with more black subjects (87.5%) developing low CBF than Caucasian (42.8%). Conclusions and Implications: There was no relationship between CSF L/P ratio and low CBF following TBI. The significance of race and low CBF is of interest and warrants additional research with a larger sample.
Repository Posting Date:
27-Oct-2011
Date of Publication:
27-Oct-2011
Conference Date:
2006
Conference Name:
18th Annual Scientific Sessions
Conference Host:
Eastern Nursing Research Society
Conference Location:
Cherry Hill, New Jersey
Description:
�New Momentum for Nursing Research: Multidisciplinary Alliances�, held on April 20th -22nd at the Hilton in Cherry Hill, New Jersey
Note:
This is an abstract-only submission. If the author has submitted a full-text item based on this abstract, you may find it by browsing the Virginia Henderson Global Nursing e-Repository by author. If author contact information is available in this abstract, please feel free to contact him or her with your queries regarding this submission. Alternatively, please contact the conference host, journal, or publisher (according to the circumstance) for further details regarding this item. If a citation is listed in this record, the item has been published and is available via open-access avenues or a journal/database subscription. Contact your library for assistance in obtaining the as-published article.

Full metadata record

DC FieldValue Language
dc.type.categoryAbstracten_US
dc.typePresentationen_GB
dc.titleThe relationship between cerebralspinal fluid lactate/pyruvate and cerebral blood flow following traumatic brain injuryen_GB
dc.contributor.authorChuang, Pei-Yingen_US
dc.contributor.authorAlexander, Sheilaen_US
dc.contributor.authorKim, Yookyungen_US
dc.author.detailsPei-Ying Chuang, University of Pittsburgh School of Nursing, Pittsburgh, Pennsylvania, USA, email: pec12@pitt.edu; Sheila Alexander; Yookyung Kim, Ph.D.en_US
dc.identifier.urihttp://hdl.handle.net/10755/163393-
dc.description.abstractPurpose: The objective of this study was to examine the relationship between CBF and CSF L/P ratio. Theoretical Framework: Cerebral ischemia is a cause of secondary injury that increases morbidity and mortality following a traumatic brain injury (TBI). Serial Xenon computed topographic (XeCT) scanning quantifies cerebral blood flow (CBF) and identified areas of ischemia; however it is only performed periodically. During ischemia, aerobic metabolism shifts to anaerobic metabolism, resulting in increased lactate/pyruvate (L/P) ratio. It is of interest to examine the cerebralspinal fluid (CSF) L/P ratio as a predictor of ischemia in the acute phase after TBI. Methods (Design, Sample, Setting, Measures, Analysis): The sample consisted of 64 subjects with a severe TBI [Glasgow Coma Score (GCS)?8], admitted to a level I trauma center, with an extraventricular drainage catheter and XeCT performed on day 1, 3, and 5. Mean CBF was obtained by averaging the mean left and right hemispheric CBF across 4 levels. Low CBF was defined as mean CBF less than 40 ml/g/min. CSF L/P ratio was drawn an average of 1.5 (SD = 7.0) hours before XeCT. Descriptive and correlational analyses were used to examine the relationship between CSF L/P ratio and CBF. Results: : The sample had a mean age of 30.5 years old (SD= 14) and was primarily male (73 %) and Caucasian (87.5%). Mean GCS was 5.7 (SD =1.4, Mode = 7). Thirty one subjects (48.4%) exhibited low CBF. No significant relationship was shown between CSF L/P ratio and low CBF (p=.13). Low CBF was significantly associated with race (p =.02) with more black subjects (87.5%) developing low CBF than Caucasian (42.8%). Conclusions and Implications: There was no relationship between CSF L/P ratio and low CBF following TBI. The significance of race and low CBF is of interest and warrants additional research with a larger sample.en_GB
dc.date.available2011-10-27T11:06:46Z-
dc.date.issued2011-10-27en_GB
dc.date.accessioned2011-10-27T11:06:46Z-
dc.conference.date2006en_US
dc.conference.name18th Annual Scientific Sessionsen_US
dc.conference.hostEastern Nursing Research Societyen_US
dc.conference.locationCherry Hill, New Jerseyen_US
dc.description�New Momentum for Nursing Research: Multidisciplinary Alliances�, held on April 20th -22nd at the Hilton in Cherry Hill, New Jerseyen_US
dc.description.noteThis is an abstract-only submission. If the author has submitted a full-text item based on this abstract, you may find it by browsing the Virginia Henderson Global Nursing e-Repository by author. If author contact information is available in this abstract, please feel free to contact him or her with your queries regarding this submission. Alternatively, please contact the conference host, journal, or publisher (according to the circumstance) for further details regarding this item. If a citation is listed in this record, the item has been published and is available via open-access avenues or a journal/database subscription. Contact your library for assistance in obtaining the as-published article.-
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