2.50
Hdl Handle:
http://hdl.handle.net/10755/163414
Category:
Abstract
Type:
Presentation
Title:
A Longitudinal Analysis of Bone Density in HIV-Infected Women
Author(s):
Dolan, Sara E.; Kanter, Jenna R.; Grinspoon, Steven
Author Details:
Sara E. Dolan, MSN, ANP, Nurse Practitioner, Partners Healthcare, Program in Nutritional Metabolism: HIV/AIDS, Boston, Massachusetts, USA, email: sdolan@partners.org; Jenna R. Kanter; Steven Grinspoon
Abstract:
Purpose: To determine if women with stable HIV are at greater risk for reduced bone mineral density (BMD) compared to healthy control subjects, and to investigate change in BMD over time in this population. Theoretical Framework: HIV and Women Methods (Design, Sample, Setting, Measures, Analysis): In this longitudinal study conducted at a university hospital, BMD was measured by DEXA in 100 HIV-infected females and 100 healthy controls similar in age (41 + 1 vs. 41 + 1 years, p=0.57), BMI (26.1 + 0.5 vs. 27.2 + 0.4 kg/m2, p=0.12), and race (60% v. 65% non-Caucasian, p=0.47, HIV-infected vs. controls). Longitudinal changes in BMD were determined in a subset of patients (n = 25 HIV vs. 25 controls) 24 months after the baseline examination. Smoking, health, and menstrual history were obtained. Results: At baseline HIV-infected subjects had lower BMD at lumbar spine (1.01 + 0.01 vs. 1.07 + 0.01, p=0.001) and hip (0.94 + 0.01 vs. 0.98 + 0.01, p=0.02). Current BMI (lumbar spine, B= 0.00794, p=0.03; hip, B = 0.00815, p=0.04) and historical low weight (spine B = 0.00145, p=0.02; hip B= 0.00196, p=0.003) were associated with lumbar spine and hip BMD in multivariate regression modeling. Duration of HIV (B= -0.00073, p=0.04) and abnormal menstrual status (B= -0.03762, p=0.01) were inversely associated with lumbar BMD. No significant association was seen between duration PI or NRTI use and reduced BMD. A significant further change in BMD was not seen between the two groups over 24 months of follow up at lumbar spine (p=0.86) or hip (p=0.54) using MANOVA. Conclusions and Implications: BMD is reduced at the spine and hip in women with HIV. A significant relationship was seen between reduced lumbar BMD and traditional factors that contribute to low BMD, including weight and menstrual function. BMD at the lumbar spine and hip remained unchanged over 2 years in women with stable HIV and weight.
Repository Posting Date:
27-Oct-2011
Date of Publication:
27-Oct-2011
Conference Date:
2006
Conference Name:
18th Annual Scientific Sessions
Conference Host:
Eastern Nursing Research Society
Conference Location:
Cherry Hill, New Jersey
Description:
�New Momentum for Nursing Research: Multidisciplinary Alliances�, held on April 20th -22nd at the Hilton in Cherry Hill, New Jersey
Note:
This is an abstract-only submission. If the author has submitted a full-text item based on this abstract, you may find it by browsing the Virginia Henderson Global Nursing e-Repository by author. If author contact information is available in this abstract, please feel free to contact him or her with your queries regarding this submission. Alternatively, please contact the conference host, journal, or publisher (according to the circumstance) for further details regarding this item. If a citation is listed in this record, the item has been published and is available via open-access avenues or a journal/database subscription. Contact your library for assistance in obtaining the as-published article.

Full metadata record

DC FieldValue Language
dc.type.categoryAbstracten_US
dc.typePresentationen_GB
dc.titleA Longitudinal Analysis of Bone Density in HIV-Infected Womenen_GB
dc.contributor.authorDolan, Sara E.en_US
dc.contributor.authorKanter, Jenna R.en_US
dc.contributor.authorGrinspoon, Stevenen_US
dc.author.detailsSara E. Dolan, MSN, ANP, Nurse Practitioner, Partners Healthcare, Program in Nutritional Metabolism: HIV/AIDS, Boston, Massachusetts, USA, email: sdolan@partners.org; Jenna R. Kanter; Steven Grinspoonen_US
dc.identifier.urihttp://hdl.handle.net/10755/163414-
dc.description.abstractPurpose: To determine if women with stable HIV are at greater risk for reduced bone mineral density (BMD) compared to healthy control subjects, and to investigate change in BMD over time in this population. Theoretical Framework: HIV and Women Methods (Design, Sample, Setting, Measures, Analysis): In this longitudinal study conducted at a university hospital, BMD was measured by DEXA in 100 HIV-infected females and 100 healthy controls similar in age (41 + 1 vs. 41 + 1 years, p=0.57), BMI (26.1 + 0.5 vs. 27.2 + 0.4 kg/m2, p=0.12), and race (60% v. 65% non-Caucasian, p=0.47, HIV-infected vs. controls). Longitudinal changes in BMD were determined in a subset of patients (n = 25 HIV vs. 25 controls) 24 months after the baseline examination. Smoking, health, and menstrual history were obtained. Results: At baseline HIV-infected subjects had lower BMD at lumbar spine (1.01 + 0.01 vs. 1.07 + 0.01, p=0.001) and hip (0.94 + 0.01 vs. 0.98 + 0.01, p=0.02). Current BMI (lumbar spine, B= 0.00794, p=0.03; hip, B = 0.00815, p=0.04) and historical low weight (spine B = 0.00145, p=0.02; hip B= 0.00196, p=0.003) were associated with lumbar spine and hip BMD in multivariate regression modeling. Duration of HIV (B= -0.00073, p=0.04) and abnormal menstrual status (B= -0.03762, p=0.01) were inversely associated with lumbar BMD. No significant association was seen between duration PI or NRTI use and reduced BMD. A significant further change in BMD was not seen between the two groups over 24 months of follow up at lumbar spine (p=0.86) or hip (p=0.54) using MANOVA. Conclusions and Implications: BMD is reduced at the spine and hip in women with HIV. A significant relationship was seen between reduced lumbar BMD and traditional factors that contribute to low BMD, including weight and menstrual function. BMD at the lumbar spine and hip remained unchanged over 2 years in women with stable HIV and weight.en_GB
dc.date.available2011-10-27T11:07:10Z-
dc.date.issued2011-10-27en_GB
dc.date.accessioned2011-10-27T11:07:10Z-
dc.conference.date2006en_US
dc.conference.name18th Annual Scientific Sessionsen_US
dc.conference.hostEastern Nursing Research Societyen_US
dc.conference.locationCherry Hill, New Jerseyen_US
dc.description�New Momentum for Nursing Research: Multidisciplinary Alliances�, held on April 20th -22nd at the Hilton in Cherry Hill, New Jerseyen_US
dc.description.noteThis is an abstract-only submission. If the author has submitted a full-text item based on this abstract, you may find it by browsing the Virginia Henderson Global Nursing e-Repository by author. If author contact information is available in this abstract, please feel free to contact him or her with your queries regarding this submission. Alternatively, please contact the conference host, journal, or publisher (according to the circumstance) for further details regarding this item. If a citation is listed in this record, the item has been published and is available via open-access avenues or a journal/database subscription. Contact your library for assistance in obtaining the as-published article.-
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