2.50
Hdl Handle:
http://hdl.handle.net/10755/163877
Category:
Abstract
Type:
Presentation
Title:
The Effect of Abortion on the Risk of Breast Cancer
Author(s):
Tehranian, Najmeh; Amelbaraez, M.; Salke, R.; Faghihzadeh, S.
Author Details:
Najmeh Tehranian, PhD, Faculty of Medical Sciences, Department of Obstetrics, Midwifery, Gynecology, Tarbiat Modarres University, Tehran, Iran, email: n_tehranian@yahoo.com; M. Amelbaraez; R. Salke; S. Faghihzadeh
Abstract:
Purpose: To assess the relationship between induced and spontaneous abortion and the subsequent incidence of breast cancer among women in Iran. Background: The hypothesis linking abortion to breast cancer postulates that undifferentiated breast epithelial cells are stimulated by the high concentrations of oestradiol released into the blood circulation by the corpus luteum in early pregnancy, and lead to the increase in the rate of cell division of breast cells -each division carrying with it the possibility of a cancer-producing mutation. During the second and third trimesters, cells appear to settle down and become more specialized in function, appearing to divide less often because of the change in the concentration of estrogen, progestrone, prolactin and b-HCG. Once a cell differentiates, it is unlikely to become cancerous. According to this cell differentiation theory, induced abortion might increase a woman's risk of breast cancer because breast cells could proliferate without the later effect of differentiation. Design: In a case-control study in the medical university of Mashhad, in 1382, 231 patients with histological-confirmed breast cancer were compared to 254 general healthy population controls. These were matched to cases by age, menstruation, family history of breast cancer, breast feeding, duration of oral contraceptive use, history of HRT and body mass index. Logistic regression was used to analyze the data, controlling for demographic and reproductive variables. Results: The risk for breast cancer in women who had a history of induced abortion at less than 12 weeks of gestation was 2.1 to 26.2 times more than those with no history of induced abortion, OR=7.94(95%CI=2.05-26.21)(P=0.002). The risk for breast cancer in women who had a history of one spontaneous abortion at more than 12 weeks of gestation was 2.5 to 16.3 times more than those with no history of spontaneous abortion, OR=6.38(95%CI=2.49-16.32)(P=0.000). The risk for breast cancer in women who had a history of two or more spontaneous abortions at more than 12 weeks of gestation was 4.8 to 55.7 times more than those with no history of spontaneous abortion, OR=16.4(95%CI=4.83-55.65) (P=0.000). Conclusion: Our findings suggest that induced and spontaneous abortion increased the risk of breast cancer.
Repository Posting Date:
27-Oct-2011
Date of Publication:
27-Oct-2011
Conference Date:
2006
Conference Host:
McMaster University
Conference Location:
Dhaka, Bangladesh
Description:
2006 International Conference: Dhaka, Bangladesh. The International Conference on the Impact of Global Issues on Women and Children, co-organized by McMaster University and the State University of Bangladesh, is an opportunity for the interdisciplinary exchange of development expertise and will be held in Dhaka, Bangladesh from February 12-16, 2006.
Note:
This is an abstract-only submission. If the author has submitted a full-text item based on this abstract, you may find it by browsing the Virginia Henderson Global Nursing e-Repository by author. If author contact information is available in this abstract, please feel free to contact him or her with your queries regarding this submission. Alternatively, please contact the conference host, journal, or publisher (according to the circumstance) for further details regarding this item. If a citation is listed in this record, the item has been published and is available via open-access avenues or a journal/database subscription. Contact your library for assistance in obtaining the as-published article.

Full metadata record

DC FieldValue Language
dc.type.categoryAbstracten_US
dc.typePresentationen_GB
dc.titleThe Effect of Abortion on the Risk of Breast Canceren_GB
dc.contributor.authorTehranian, Najmehen_US
dc.contributor.authorAmelbaraez, M.en_US
dc.contributor.authorSalke, R.en_US
dc.contributor.authorFaghihzadeh, S.en_US
dc.author.detailsNajmeh Tehranian, PhD, Faculty of Medical Sciences, Department of Obstetrics, Midwifery, Gynecology, Tarbiat Modarres University, Tehran, Iran, email: n_tehranian@yahoo.com; M. Amelbaraez; R. Salke; S. Faghihzadehen_US
dc.identifier.urihttp://hdl.handle.net/10755/163877-
dc.description.abstractPurpose: To assess the relationship between induced and spontaneous abortion and the subsequent incidence of breast cancer among women in Iran. Background: The hypothesis linking abortion to breast cancer postulates that undifferentiated breast epithelial cells are stimulated by the high concentrations of oestradiol released into the blood circulation by the corpus luteum in early pregnancy, and lead to the increase in the rate of cell division of breast cells -each division carrying with it the possibility of a cancer-producing mutation. During the second and third trimesters, cells appear to settle down and become more specialized in function, appearing to divide less often because of the change in the concentration of estrogen, progestrone, prolactin and b-HCG. Once a cell differentiates, it is unlikely to become cancerous. According to this cell differentiation theory, induced abortion might increase a woman's risk of breast cancer because breast cells could proliferate without the later effect of differentiation. Design: In a case-control study in the medical university of Mashhad, in 1382, 231 patients with histological-confirmed breast cancer were compared to 254 general healthy population controls. These were matched to cases by age, menstruation, family history of breast cancer, breast feeding, duration of oral contraceptive use, history of HRT and body mass index. Logistic regression was used to analyze the data, controlling for demographic and reproductive variables. Results: The risk for breast cancer in women who had a history of induced abortion at less than 12 weeks of gestation was 2.1 to 26.2 times more than those with no history of induced abortion, OR=7.94(95%CI=2.05-26.21)(P=0.002). The risk for breast cancer in women who had a history of one spontaneous abortion at more than 12 weeks of gestation was 2.5 to 16.3 times more than those with no history of spontaneous abortion, OR=6.38(95%CI=2.49-16.32)(P=0.000). The risk for breast cancer in women who had a history of two or more spontaneous abortions at more than 12 weeks of gestation was 4.8 to 55.7 times more than those with no history of spontaneous abortion, OR=16.4(95%CI=4.83-55.65) (P=0.000). Conclusion: Our findings suggest that induced and spontaneous abortion increased the risk of breast cancer.en_GB
dc.date.available2011-10-27T11:34:07Z-
dc.date.issued2011-10-27en_GB
dc.date.accessioned2011-10-27T11:34:07Z-
dc.conference.date2006-
dc.conference.hostMcMaster Universityen_US
dc.conference.locationDhaka, Bangladeshen_US
dc.description2006 International Conference: Dhaka, Bangladesh. The International Conference on the Impact of Global Issues on Women and Children, co-organized by McMaster University and the State University of Bangladesh, is an opportunity for the interdisciplinary exchange of development expertise and will be held in Dhaka, Bangladesh from February 12-16, 2006.en_US
dc.description.noteThis is an abstract-only submission. If the author has submitted a full-text item based on this abstract, you may find it by browsing the Virginia Henderson Global Nursing e-Repository by author. If author contact information is available in this abstract, please feel free to contact him or her with your queries regarding this submission. Alternatively, please contact the conference host, journal, or publisher (according to the circumstance) for further details regarding this item. If a citation is listed in this record, the item has been published and is available via open-access avenues or a journal/database subscription. Contact your library for assistance in obtaining the as-published article.-
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