2.50
Hdl Handle:
http://hdl.handle.net/10755/164640
Category:
Abstract
Type:
Presentation
Title:
Symptom Trajectory Following 12 Weeks of Biotherapy
Author(s):
Visovsky, Constance
Author Details:
Constance Visovsky, Case Western Reserve University, Frances Payne Bolton School of Nursing, Cleveland, Ohio, USA, email: cxv6@po.cwru.edu
Abstract:
SIGNIFICANCE: Patients treated for cancer with biotherapy experience alterations in muscle strength, peripheral nerve function and increases in symptom distress. Studies of biotherapy-induced physiological changes have been few, and patients are not systematically monitored for long-term effects. Thus, the physiological changes accompanying biotherapy treatment represents changes in function for which patients and families are ill prepared. Limited data exist quantifying physiologic changes in muscle and peripheral nerve function in individuals receiving biotherapy. PURPOSE: The purpose of this prospective, exploratory pilot study was to determine: 1) the change in muscle strength, peripheral nerve function and symptom distress during treatment with biotherapy; 2) to determine the relationship between the extent of these physiologic changes and symptom distress. THEORETICAL FRAMEWORK: A physiological framework of neuronal degeneration and skeletal muscle alterations was used. METHODS: A convenience sample of 11 subjects with malignant melanoma receiving biotherapy had measures of peripheral nerve and muscle function measured at baseline, 4 and 12 weeks of treatment. A prospective, exploratory design was used. Data was analyzed using plots and regression slopes to determine change over time in peripheral nerve and muscle function and associated symptom distress. Independent variables were age, gender and cumulative drug dose. Outcome variables were sensation, gait/balance, vision, hearing, vibratory sense, deep tendon reflexes, blood pressure, and symptom distress. RESULTS: Declines in hearing, vibratory sensation, deep tendon reflexes, and muscle strength were found. Changes in visual acuity, and orthostatic blood pressure were noted from baseline to 12 weeks while gait/balance remained stable. Alterations in peripheral nerve symptoms were associated with increases in symptom distress. Symptom distress increased from baseline to 4 weeks and began to decline by 12 weeks. IMPLICATIONS FOR PRACTICE: The characterization of peripheral nerve and muscle changes can assist in understanding the nature of the physiological effects associated with high-dose biotherapy treatment and aid in preparing patients for anticipated changes in function and subsequent life-style adjustments. Study findings are essential to foster the development of interventions aimed at preserving functional status and decreasing symptom distress in patients receiving cancer treatment with biologic agents.
Repository Posting Date:
27-Oct-2011
Date of Publication:
27-Oct-2011
Conference Date:
2003
Conference Name:
28th Annual Oncology Nursing Society Congress
Conference Host:
Oncology Nursing Society
Conference Location:
Denver, Colorado, USA
Note:
This is an abstract-only submission. If the author has submitted a full-text item based on this abstract, you may find it by browsing the Virginia Henderson Global Nursing e-Repository by author. If author contact information is available in this abstract, please feel free to contact him or her with your queries regarding this submission. Alternatively, please contact the conference host, journal, or publisher (according to the circumstance) for further details regarding this item. If a citation is listed in this record, the item has been published and is available via open-access avenues or a journal/database subscription. Contact your library for assistance in obtaining the as-published article.

Full metadata record

DC FieldValue Language
dc.type.categoryAbstracten_US
dc.typePresentationen_GB
dc.titleSymptom Trajectory Following 12 Weeks of Biotherapyen_GB
dc.contributor.authorVisovsky, Constanceen_US
dc.author.detailsConstance Visovsky, Case Western Reserve University, Frances Payne Bolton School of Nursing, Cleveland, Ohio, USA, email: cxv6@po.cwru.eduen_US
dc.identifier.urihttp://hdl.handle.net/10755/164640-
dc.description.abstractSIGNIFICANCE: Patients treated for cancer with biotherapy experience alterations in muscle strength, peripheral nerve function and increases in symptom distress. Studies of biotherapy-induced physiological changes have been few, and patients are not systematically monitored for long-term effects. Thus, the physiological changes accompanying biotherapy treatment represents changes in function for which patients and families are ill prepared. Limited data exist quantifying physiologic changes in muscle and peripheral nerve function in individuals receiving biotherapy. PURPOSE: The purpose of this prospective, exploratory pilot study was to determine: 1) the change in muscle strength, peripheral nerve function and symptom distress during treatment with biotherapy; 2) to determine the relationship between the extent of these physiologic changes and symptom distress. THEORETICAL FRAMEWORK: A physiological framework of neuronal degeneration and skeletal muscle alterations was used. METHODS: A convenience sample of 11 subjects with malignant melanoma receiving biotherapy had measures of peripheral nerve and muscle function measured at baseline, 4 and 12 weeks of treatment. A prospective, exploratory design was used. Data was analyzed using plots and regression slopes to determine change over time in peripheral nerve and muscle function and associated symptom distress. Independent variables were age, gender and cumulative drug dose. Outcome variables were sensation, gait/balance, vision, hearing, vibratory sense, deep tendon reflexes, blood pressure, and symptom distress. RESULTS: Declines in hearing, vibratory sensation, deep tendon reflexes, and muscle strength were found. Changes in visual acuity, and orthostatic blood pressure were noted from baseline to 12 weeks while gait/balance remained stable. Alterations in peripheral nerve symptoms were associated with increases in symptom distress. Symptom distress increased from baseline to 4 weeks and began to decline by 12 weeks. IMPLICATIONS FOR PRACTICE: The characterization of peripheral nerve and muscle changes can assist in understanding the nature of the physiological effects associated with high-dose biotherapy treatment and aid in preparing patients for anticipated changes in function and subsequent life-style adjustments. Study findings are essential to foster the development of interventions aimed at preserving functional status and decreasing symptom distress in patients receiving cancer treatment with biologic agents.en_GB
dc.date.available2011-10-27T12:04:21Z-
dc.date.issued2011-10-27en_GB
dc.date.accessioned2011-10-27T12:04:21Z-
dc.conference.date2003en_US
dc.conference.name28th Annual Oncology Nursing Society Congressen_US
dc.conference.hostOncology Nursing Societyen_US
dc.conference.locationDenver, Colorado, USAen_US
dc.description.noteThis is an abstract-only submission. If the author has submitted a full-text item based on this abstract, you may find it by browsing the Virginia Henderson Global Nursing e-Repository by author. If author contact information is available in this abstract, please feel free to contact him or her with your queries regarding this submission. Alternatively, please contact the conference host, journal, or publisher (according to the circumstance) for further details regarding this item. If a citation is listed in this record, the item has been published and is available via open-access avenues or a journal/database subscription. Contact your library for assistance in obtaining the as-published article.-
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