2.50
Hdl Handle:
http://hdl.handle.net/10755/164763
Category:
Abstract
Type:
Presentation
Title:
2.5 Times The Upper Limit Of Normal - Grading Laboratory Adverse Events
Author(s):
Lopez, Vilma
Author Details:
Vilma Lopez RN, MSN, OCN, Senior Research Nurse, UT M.D. Anderson Cancer Center, Houston, Texas, USA, email: vlopez@mdanderson.org
Abstract:
Clinical/Evidence Based Practice: Clinical Trial Nurses (CTNs) routinely report adverse events caused by cancer therapy. NCI published the CTCAE to standardize adverse event reporting with a grading scale for each Adverse Event (AE) term. Blood/Bone Marrow and Metabolic/Laboratory categories provide specific parameters for each grade, based on reference ranges. Reference ranges, are often referred as "normals" and each laboratory publishes its own normal ranges. For grading AE's CTNs need to review laboratory results for each test and subject. Find the "normals" for the laboratory that performed the tests, check for gender specific variations, and match results with the CTCAE grading scale. In Pediatrics, the challenge is bigger because "normals" vary by age. Average number of tests performed by visit is 10 to 12. Literature search showed no returns for Adverse Event calculators. The purpose is to simplify calculations, saving valuable nursing time. The CTN needs to get the normals once, get grading rules once, set up a calculator and make it transferable. I selected most frequent tests which have numerical values results, identified gender and age variations, and patterned the grading scale by method of calculation, i.e. factors, values, or combination of both. I designed a spreadsheet in Excel to perform the calculations. The calculator returns a grade when a test is selected and a value entered. The calculator is self standing. Compare time employed to grade AEs by using traditional method versus calculator, for each laboratory value. Calculator will have to be updated when "normals" change or if grading scale is modified. Nurses in our department will time AE evaluations for both traditional and AE calculator methods. Calculator use will help CTNs in reporting AEs and for submitting information to the investigator for dose modifications. Once set up anybody can use it. It can be e-mailed or shared. "Normals" for other laboratories can be easily substituted. Alternatively, the calculator can be used as a prototype for system design where calculations can be programmed into a database which will return the AEÆs grade with each laboratory result.
Repository Posting Date:
27-Oct-2011
Date of Publication:
27-Oct-2011
Conference Date:
2009
Conference Name:
34th Annual Oncology Nursing Society Congress
Conference Host:
Oncology Nursing Society
Conference Location:
San Antonio, Texas, USA
Note:
This is an abstract-only submission. If the author has submitted a full-text item based on this abstract, you may find it by browsing the Virginia Henderson Global Nursing e-Repository by author. If author contact information is available in this abstract, please feel free to contact him or her with your queries regarding this submission. Alternatively, please contact the conference host, journal, or publisher (according to the circumstance) for further details regarding this item. If a citation is listed in this record, the item has been published and is available via open-access avenues or a journal/database subscription. Contact your library for assistance in obtaining the as-published article.

Full metadata record

DC FieldValue Language
dc.type.categoryAbstracten_US
dc.typePresentationen_GB
dc.title2.5 Times The Upper Limit Of Normal - Grading Laboratory Adverse Eventsen_GB
dc.contributor.authorLopez, Vilmaen_US
dc.author.detailsVilma Lopez RN, MSN, OCN, Senior Research Nurse, UT M.D. Anderson Cancer Center, Houston, Texas, USA, email: vlopez@mdanderson.orgen_US
dc.identifier.urihttp://hdl.handle.net/10755/164763-
dc.description.abstractClinical/Evidence Based Practice: Clinical Trial Nurses (CTNs) routinely report adverse events caused by cancer therapy. NCI published the CTCAE to standardize adverse event reporting with a grading scale for each Adverse Event (AE) term. Blood/Bone Marrow and Metabolic/Laboratory categories provide specific parameters for each grade, based on reference ranges. Reference ranges, are often referred as "normals" and each laboratory publishes its own normal ranges. For grading AE's CTNs need to review laboratory results for each test and subject. Find the "normals" for the laboratory that performed the tests, check for gender specific variations, and match results with the CTCAE grading scale. In Pediatrics, the challenge is bigger because "normals" vary by age. Average number of tests performed by visit is 10 to 12. Literature search showed no returns for Adverse Event calculators. The purpose is to simplify calculations, saving valuable nursing time. The CTN needs to get the normals once, get grading rules once, set up a calculator and make it transferable. I selected most frequent tests which have numerical values results, identified gender and age variations, and patterned the grading scale by method of calculation, i.e. factors, values, or combination of both. I designed a spreadsheet in Excel to perform the calculations. The calculator returns a grade when a test is selected and a value entered. The calculator is self standing. Compare time employed to grade AEs by using traditional method versus calculator, for each laboratory value. Calculator will have to be updated when "normals" change or if grading scale is modified. Nurses in our department will time AE evaluations for both traditional and AE calculator methods. Calculator use will help CTNs in reporting AEs and for submitting information to the investigator for dose modifications. Once set up anybody can use it. It can be e-mailed or shared. "Normals" for other laboratories can be easily substituted. Alternatively, the calculator can be used as a prototype for system design where calculations can be programmed into a database which will return the AEÆs grade with each laboratory result.en_GB
dc.date.available2011-10-27T12:06:33Z-
dc.date.issued2011-10-27en_GB
dc.date.accessioned2011-10-27T12:06:33Z-
dc.conference.date2009en_US
dc.conference.name34th Annual Oncology Nursing Society Congressen_US
dc.conference.hostOncology Nursing Societyen_US
dc.conference.locationSan Antonio, Texas, USAen_US
dc.description.noteThis is an abstract-only submission. If the author has submitted a full-text item based on this abstract, you may find it by browsing the Virginia Henderson Global Nursing e-Repository by author. If author contact information is available in this abstract, please feel free to contact him or her with your queries regarding this submission. Alternatively, please contact the conference host, journal, or publisher (according to the circumstance) for further details regarding this item. If a citation is listed in this record, the item has been published and is available via open-access avenues or a journal/database subscription. Contact your library for assistance in obtaining the as-published article.-
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