A Randomized Trial of Exercise for Newly Diagnosed Patients Receiving Chemotherapy: Effects On Bone Density and Body Composition

2.50
Hdl Handle:
http://hdl.handle.net/10755/164864
Category:
Abstract
Type:
Presentation
Title:
A Randomized Trial of Exercise for Newly Diagnosed Patients Receiving Chemotherapy: Effects On Bone Density and Body Composition
Author(s):
Schwartz, Anna
Author Details:
Anna Schwartz, Associate Professor, Oregon Health & Science University, Portland, Oregon, USA, email: schwarta@ohsu.edu
Abstract:
Problem: During chemotherapy, it is common to observe declines in functional ability and muscle strength and increases in body weight. Chemotherapy, particularly doxorubicin or methotrexate in combination with steroids, increases the potential for significant physical decline and predispose patients to osteoporosis. Exercise may be a means of minimizing these negative effects and decreasing risks for long-term treatment-related complications such as osteoporosis and weight gain. Conceptual Framework: The hypokinetic theory forms the conceptual basis for this study that examines the effects of exercise on bone health, body composition, and functional ability. Purpose: The purpose of this longitudinal, randomized, repeated measures study was to examine the effects of exercise on functional ability, muscle strength, bone density (BMD), and body composition in newly diagnosed cancer patients beginning chemotherapy with doxorubicin or methotrexate and a steroid. Methods: 66 newly diagnosed cancer patients (5 males/61 females) beginning chemotherapy regimens were randomized to aerobic exercise (AE) (N = 23), resistance exercise (RE) (N = 22), or usual care control (CG) (N = 21). Exercise subjects were instructed to follow a four-day/week home-based program. All subjects returned for follow-up exercise testing at three-month intervals and bone densitometry scanning (DEXA) of the L-spine and total body at baseline and six months. Data Analysis: Descriptive analyses and repeated measures analysis of variance were use to examine differences between the groups over time. Findings: Greater increases in functional ability were observed in the AE (16%) than the RE (9%) or CG (8%). Muscle strength significantly increased in the AE and RE group, and declined in CG (p < .05). The mean decrease in BMD at the L-spine was 4.3% (SD = 4.6, range = -16.4 to 2.9). Significantly less decline in L-spine BMD was observed in AE (-1.6%) compared to RE (-5.3%) and CG (-5.9%) (p<.05, F=4.7). No significant changes in body fat were observed between groups. Implications: Findings support the idea that AE may reduce the bone-wasting effects of chemotherapy and may assist in maintaining or improving body composition, functional ability, and muscle strength during chemotherapy. These outcomes may be critical to improving quality of life and reducing risks for long-term treatment related side effects.
Repository Posting Date:
27-Oct-2011
Date of Publication:
27-Oct-2011
Conference Date:
2002
Conference Name:
27th Annual Oncology Nursing Society Congress
Conference Host:
Oncology Nursing Society
Conference Location:
Washington, D.C., USA
Note:
This is an abstract-only submission. If the author has submitted a full-text item based on this abstract, you may find it by browsing the Virginia Henderson Global Nursing e-Repository by author. If author contact information is available in this abstract, please feel free to contact him or her with your queries regarding this submission. Alternatively, please contact the conference host, journal, or publisher (according to the circumstance) for further details regarding this item. If a citation is listed in this record, the item has been published and is available via open-access avenues or a journal/database subscription. Contact your library for assistance in obtaining the as-published article.

Full metadata record

DC FieldValue Language
dc.type.categoryAbstracten_US
dc.typePresentationen_GB
dc.titleA Randomized Trial of Exercise for Newly Diagnosed Patients Receiving Chemotherapy: Effects On Bone Density and Body Compositionen_GB
dc.contributor.authorSchwartz, Annaen_US
dc.author.detailsAnna Schwartz, Associate Professor, Oregon Health & Science University, Portland, Oregon, USA, email: schwarta@ohsu.eduen_US
dc.identifier.urihttp://hdl.handle.net/10755/164864-
dc.description.abstractProblem: During chemotherapy, it is common to observe declines in functional ability and muscle strength and increases in body weight. Chemotherapy, particularly doxorubicin or methotrexate in combination with steroids, increases the potential for significant physical decline and predispose patients to osteoporosis. Exercise may be a means of minimizing these negative effects and decreasing risks for long-term treatment-related complications such as osteoporosis and weight gain. Conceptual Framework: The hypokinetic theory forms the conceptual basis for this study that examines the effects of exercise on bone health, body composition, and functional ability. Purpose: The purpose of this longitudinal, randomized, repeated measures study was to examine the effects of exercise on functional ability, muscle strength, bone density (BMD), and body composition in newly diagnosed cancer patients beginning chemotherapy with doxorubicin or methotrexate and a steroid. Methods: 66 newly diagnosed cancer patients (5 males/61 females) beginning chemotherapy regimens were randomized to aerobic exercise (AE) (N = 23), resistance exercise (RE) (N = 22), or usual care control (CG) (N = 21). Exercise subjects were instructed to follow a four-day/week home-based program. All subjects returned for follow-up exercise testing at three-month intervals and bone densitometry scanning (DEXA) of the L-spine and total body at baseline and six months. Data Analysis: Descriptive analyses and repeated measures analysis of variance were use to examine differences between the groups over time. Findings: Greater increases in functional ability were observed in the AE (16%) than the RE (9%) or CG (8%). Muscle strength significantly increased in the AE and RE group, and declined in CG (p &lt; .05). The mean decrease in BMD at the L-spine was 4.3% (SD = 4.6, range = -16.4 to 2.9). Significantly less decline in L-spine BMD was observed in AE (-1.6%) compared to RE (-5.3%) and CG (-5.9%) (p&lt;.05, F=4.7). No significant changes in body fat were observed between groups. Implications: Findings support the idea that AE may reduce the bone-wasting effects of chemotherapy and may assist in maintaining or improving body composition, functional ability, and muscle strength during chemotherapy. These outcomes may be critical to improving quality of life and reducing risks for long-term treatment related side effects.en_GB
dc.date.available2011-10-27T12:08:22Z-
dc.date.issued2011-10-27en_GB
dc.date.accessioned2011-10-27T12:08:22Z-
dc.conference.date2002en_US
dc.conference.name27th Annual Oncology Nursing Society Congressen_US
dc.conference.hostOncology Nursing Societyen_US
dc.conference.locationWashington, D.C., USAen_US
dc.description.noteThis is an abstract-only submission. If the author has submitted a full-text item based on this abstract, you may find it by browsing the Virginia Henderson Global Nursing e-Repository by author. If author contact information is available in this abstract, please feel free to contact him or her with your queries regarding this submission. Alternatively, please contact the conference host, journal, or publisher (according to the circumstance) for further details regarding this item. If a citation is listed in this record, the item has been published and is available via open-access avenues or a journal/database subscription. Contact your library for assistance in obtaining the as-published article.-
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