THE INFLUENCE OF ORAL FOOD INTAKE ON PATIENTS WITH ORAL MUCOSITIS FOLLOWING ALLOGENEIC HEMATOPOIETIC STEM CELL TRANSPLANTATION

2.50
Hdl Handle:
http://hdl.handle.net/10755/164908
Category:
Abstract
Type:
Presentation
Title:
THE INFLUENCE OF ORAL FOOD INTAKE ON PATIENTS WITH ORAL MUCOSITIS FOLLOWING ALLOGENEIC HEMATOPOIETIC STEM CELL TRANSPLANTATION
Author(s):
Watanabe, Rumi; Yamashita, Hiro; Amamoto, Kayo; Watanabe, Akiko; Yokouchi, Sari; Kozuka, Terihiko
Author Details:
Rumi Watanabe, Staff nurse, Ehime Prefectural Central Hospital, Matsuyama, Japan, email: rumigai@yahoo.co.jp; Hiroe Yamashita, RN; Kayo Yamamoto, RN; Akiko Watanabe, RN; Saori Yokouchi, RN; Teruhiko Kozuka, MD, PhD
Abstract:
Oral mucositis is a frequent complication of the high-dose chemotherapy and total body irradiation commonly used in hematopoietic stem cell transplantation. In patients undergoing hematopoietic stem cell transplantation, oral mucositis has a high infection and mortality rate. Therefore, its prevention and associated therapy are important. Management for oral mucositis is integral to the role of the oncology nurse. In a previous study we showed bacterial numbers in the oral cavity decreased after a meal or gargling. We thus hypothesized that a reduction of oral mucositis may be induced by oral intake in patients who underwent allogeneic hematopoietic stem cell transplantation. The purpose of this study was to investigate retrospectively the relationship between oral intake and oral mucositis following allogeneic hematopoietic stem cell transplantation. A retrospective comparison study is appropriate for this research. Data for this study were taken from the medical records from April 2002 to January 2006 of 78 patients. Data concerning conditions of oral intake and oral mucositis during the period from beginning a transplant conditioning regimen to neutrophil engraftment were collected. Grades of oral mucositis were evaluated using NCI Common Terminology Criteria for Adverse Events (CTCAE) v3.0. The relationships between the number of times of a meal was taken and the period when oral mucositis was observed, and between the quantity of the meal and the period when oral mucositis was observed revealed significant weak inverse correlations, respectively (r=-0.298 p=0.014, and r=-0.336 0.0056). The relationship between the number of times of a meal was taken and the highest grade of oral mucositis also revealed a significant weak inverse correlation (r=-0.238 p=0.0397). After nadir, the highest grade of oral mucositis significantly rose (p=0.0422), and the period when patients could have an oral intake was significantly shortened (p<0.0001). This study suggested that continuous oral intake during allogeneic hematopoietic stem cell transplantation may prevent severe oral mucositis. Gargling to prevent free radicals until nadir when secondary oral mucositis occurs along with continuous oral intake during all periods appear crucial for preventing severe oral mucositis.
Repository Posting Date:
27-Oct-2011
Date of Publication:
27-Oct-2011
Conference Date:
2007
Conference Name:
32nd Annual Oncology Nursing Society Congress
Conference Host:
Oncology Nursing Society
Conference Location:
Las Vegas, Nevada, USA
Note:
This is an abstract-only submission. If the author has submitted a full-text item based on this abstract, you may find it by browsing the Virginia Henderson Global Nursing e-Repository by author. If author contact information is available in this abstract, please feel free to contact him or her with your queries regarding this submission. Alternatively, please contact the conference host, journal, or publisher (according to the circumstance) for further details regarding this item. If a citation is listed in this record, the item has been published and is available via open-access avenues or a journal/database subscription. Contact your library for assistance in obtaining the as-published article.

Full metadata record

DC FieldValue Language
dc.type.categoryAbstracten_US
dc.typePresentationen_GB
dc.titleTHE INFLUENCE OF ORAL FOOD INTAKE ON PATIENTS WITH ORAL MUCOSITIS FOLLOWING ALLOGENEIC HEMATOPOIETIC STEM CELL TRANSPLANTATIONen_GB
dc.contributor.authorWatanabe, Rumien_US
dc.contributor.authorYamashita, Hiroen_US
dc.contributor.authorAmamoto, Kayoen_US
dc.contributor.authorWatanabe, Akikoen_US
dc.contributor.authorYokouchi, Sarien_US
dc.contributor.authorKozuka, Terihikoen_US
dc.author.detailsRumi Watanabe, Staff nurse, Ehime Prefectural Central Hospital, Matsuyama, Japan, email: rumigai@yahoo.co.jp; Hiroe Yamashita, RN; Kayo Yamamoto, RN; Akiko Watanabe, RN; Saori Yokouchi, RN; Teruhiko Kozuka, MD, PhDen_US
dc.identifier.urihttp://hdl.handle.net/10755/164908-
dc.description.abstractOral mucositis is a frequent complication of the high-dose chemotherapy and total body irradiation commonly used in hematopoietic stem cell transplantation. In patients undergoing hematopoietic stem cell transplantation, oral mucositis has a high infection and mortality rate. Therefore, its prevention and associated therapy are important. Management for oral mucositis is integral to the role of the oncology nurse. In a previous study we showed bacterial numbers in the oral cavity decreased after a meal or gargling. We thus hypothesized that a reduction of oral mucositis may be induced by oral intake in patients who underwent allogeneic hematopoietic stem cell transplantation. The purpose of this study was to investigate retrospectively the relationship between oral intake and oral mucositis following allogeneic hematopoietic stem cell transplantation. A retrospective comparison study is appropriate for this research. Data for this study were taken from the medical records from April 2002 to January 2006 of 78 patients. Data concerning conditions of oral intake and oral mucositis during the period from beginning a transplant conditioning regimen to neutrophil engraftment were collected. Grades of oral mucositis were evaluated using NCI Common Terminology Criteria for Adverse Events (CTCAE) v3.0. The relationships between the number of times of a meal was taken and the period when oral mucositis was observed, and between the quantity of the meal and the period when oral mucositis was observed revealed significant weak inverse correlations, respectively (r=-0.298 p=0.014, and r=-0.336 0.0056). The relationship between the number of times of a meal was taken and the highest grade of oral mucositis also revealed a significant weak inverse correlation (r=-0.238 p=0.0397). After nadir, the highest grade of oral mucositis significantly rose (p=0.0422), and the period when patients could have an oral intake was significantly shortened (p&lt;0.0001). This study suggested that continuous oral intake during allogeneic hematopoietic stem cell transplantation may prevent severe oral mucositis. Gargling to prevent free radicals until nadir when secondary oral mucositis occurs along with continuous oral intake during all periods appear crucial for preventing severe oral mucositis. </td></tr></table>en_GB
dc.date.available2011-10-27T12:09:07Z-
dc.date.issued2011-10-27en_GB
dc.date.accessioned2011-10-27T12:09:07Z-
dc.conference.date2007en_US
dc.conference.name32nd Annual Oncology Nursing Society Congressen_US
dc.conference.hostOncology Nursing Societyen_US
dc.conference.locationLas Vegas, Nevada, USAen_US
dc.description.noteThis is an abstract-only submission. If the author has submitted a full-text item based on this abstract, you may find it by browsing the Virginia Henderson Global Nursing e-Repository by author. If author contact information is available in this abstract, please feel free to contact him or her with your queries regarding this submission. Alternatively, please contact the conference host, journal, or publisher (according to the circumstance) for further details regarding this item. If a citation is listed in this record, the item has been published and is available via open-access avenues or a journal/database subscription. Contact your library for assistance in obtaining the as-published article.-
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