PATTERNS OF FATIGUE AND EFFECT OF EXERCISE IN BREAST CANCER PATIENTS RECEIVING CHEMOTHERAPY

2.50
Hdl Handle:
http://hdl.handle.net/10755/164913
Category:
Abstract
Type:
Presentation
Title:
PATTERNS OF FATIGUE AND EFFECT OF EXERCISE IN BREAST CANCER PATIENTS RECEIVING CHEMOTHERAPY
Author(s):
Wu, Horng-Shiuann; Dodd, Marylin
Author Details:
Horng-Shiuann Wu, PHD RN, Assistant Adjunct Professor, University of California San Francisco, San Francisco, California, USA, email: horng-shiuann.wu@nursing.ucsf.edu; Marylin Dodd, PhD, RN, FAAN; Maria Cho, PhD, RN
Abstract:
Cancer-related fatigue (CRF) is long lasting and the most impairing cancer-related symptom. Its mechanisms have not been established; its fluctuating nature makes CRF difficult to manage. There is a need for systematic evaluation of different therapies, including exercise on CRF. To examine the daily pattern of CRF during the third cycle of chemotherapy in women with breast cancer; to predict whether CRF trajectories differ by exercise behaviors. Piper's Integrated Fatigue Model. The data were collected as part of a randomized clinical trial to test the effectiveness of a systematic exercise intervention on fatigue. A total of 98 female breast cancer outpatients, ages 28 to 72 (M= 49.5, SD=9.3), majority (79%) receiving standard doxorubicin/ cyclophosphamide (AC) chemotherapy, in five cancer centers were included in this report. Exercise behaviors, defined by the Surgeon General's Guideline for Physical Activity, were classified as exercisers (n=40) or non-exercisers (n=52). Fatigue intensity was measured daily at bedtime for the entire 21-day cycle, beginning on the first day of the third chemotherapy cycle. Average and worst fatigue levels in the last 24 hours were measured on an 11- point numeric rating scale ranging from 0, no fatigue/tiredness, to 10, overwhelming fatigue/tiredness. Multilevel modeling was used to estimate how fatigue changed over time and with exercise behaviors. The predicted average and worst fatigue on the first day of chemotherapy for non-exercisers was 4.7 and 6.2. Non-exercisers experienced 1.1 (P<0.01) higher average fatigue and 1.2 (P<0.01) higher worst fatigue than exercisers on the first day of chemotherapy. Average and worst fatigue declined significantly over time (P<0.001) and the decreases were not significantly different in exercisers and non-exercisers. Results also demonstrated a cubic change trajectory of daily fatigue during the third cycle of chemotherapy, with a peak right after chemotherapy and a trough few days before the next cycle. Information on the pattern of fatigue is crucial in preparing cancer patients for chemotherapy and determining the timing of interventions and measurement of outcomes. This report furthers the understanding of the pattern of fatigue and the effect of exercise.
Repository Posting Date:
27-Oct-2011
Date of Publication:
27-Oct-2011
Conference Date:
2007
Conference Name:
32nd Annual Oncology Nursing Society Congress
Conference Host:
Oncology Nursing Society
Conference Location:
Las Vegas, Nevada, USA
Note:
This is an abstract-only submission. If the author has submitted a full-text item based on this abstract, you may find it by browsing the Virginia Henderson Global Nursing e-Repository by author. If author contact information is available in this abstract, please feel free to contact him or her with your queries regarding this submission. Alternatively, please contact the conference host, journal, or publisher (according to the circumstance) for further details regarding this item. If a citation is listed in this record, the item has been published and is available via open-access avenues or a journal/database subscription. Contact your library for assistance in obtaining the as-published article.

Full metadata record

DC FieldValue Language
dc.type.categoryAbstracten_US
dc.typePresentationen_GB
dc.titlePATTERNS OF FATIGUE AND EFFECT OF EXERCISE IN BREAST CANCER PATIENTS RECEIVING CHEMOTHERAPYen_GB
dc.contributor.authorWu, Horng-Shiuannen_US
dc.contributor.authorDodd, Marylinen_US
dc.author.detailsHorng-Shiuann Wu, PHD RN, Assistant Adjunct Professor, University of California San Francisco, San Francisco, California, USA, email: horng-shiuann.wu@nursing.ucsf.edu; Marylin Dodd, PhD, RN, FAAN; Maria Cho, PhD, RNen_US
dc.identifier.urihttp://hdl.handle.net/10755/164913-
dc.description.abstractCancer-related fatigue (CRF) is long lasting and the most impairing cancer-related symptom. Its mechanisms have not been established; its fluctuating nature makes CRF difficult to manage. There is a need for systematic evaluation of different therapies, including exercise on CRF. To examine the daily pattern of CRF during the third cycle of chemotherapy in women with breast cancer; to predict whether CRF trajectories differ by exercise behaviors. Piper's Integrated Fatigue Model. The data were collected as part of a randomized clinical trial to test the effectiveness of a systematic exercise intervention on fatigue. A total of 98 female breast cancer outpatients, ages 28 to 72 (M= 49.5, SD=9.3), majority (79%) receiving standard doxorubicin/ cyclophosphamide (AC) chemotherapy, in five cancer centers were included in this report. Exercise behaviors, defined by the Surgeon General's Guideline for Physical Activity, were classified as exercisers (n=40) or non-exercisers (n=52). Fatigue intensity was measured daily at bedtime for the entire 21-day cycle, beginning on the first day of the third chemotherapy cycle. Average and worst fatigue levels in the last 24 hours were measured on an 11- point numeric rating scale ranging from 0, no fatigue/tiredness, to 10, overwhelming fatigue/tiredness. Multilevel modeling was used to estimate how fatigue changed over time and with exercise behaviors. The predicted average and worst fatigue on the first day of chemotherapy for non-exercisers was 4.7 and 6.2. Non-exercisers experienced 1.1 (P&lt;0.01) higher average fatigue and 1.2 (P&lt;0.01) higher worst fatigue than exercisers on the first day of chemotherapy. Average and worst fatigue declined significantly over time (P&lt;0.001) and the decreases were not significantly different in exercisers and non-exercisers. Results also demonstrated a cubic change trajectory of daily fatigue during the third cycle of chemotherapy, with a peak right after chemotherapy and a trough few days before the next cycle. Information on the pattern of fatigue is crucial in preparing cancer patients for chemotherapy and determining the timing of interventions and measurement of outcomes. This report furthers the understanding of the pattern of fatigue and the effect of exercise.en_GB
dc.date.available2011-10-27T12:09:12Z-
dc.date.issued2011-10-27en_GB
dc.date.accessioned2011-10-27T12:09:12Z-
dc.conference.date2007en_US
dc.conference.name32nd Annual Oncology Nursing Society Congressen_US
dc.conference.hostOncology Nursing Societyen_US
dc.conference.locationLas Vegas, Nevada, USAen_US
dc.description.noteThis is an abstract-only submission. If the author has submitted a full-text item based on this abstract, you may find it by browsing the Virginia Henderson Global Nursing e-Repository by author. If author contact information is available in this abstract, please feel free to contact him or her with your queries regarding this submission. Alternatively, please contact the conference host, journal, or publisher (according to the circumstance) for further details regarding this item. If a citation is listed in this record, the item has been published and is available via open-access avenues or a journal/database subscription. Contact your library for assistance in obtaining the as-published article.-
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