Is Obesity a Prognostic Indicator for Ovarian Cancer?: A Systematic Review of the Literature

2.50
Hdl Handle:
http://hdl.handle.net/10755/164916
Category:
Abstract
Type:
Presentation
Title:
Is Obesity a Prognostic Indicator for Ovarian Cancer?: A Systematic Review of the Literature
Author(s):
Adkins, Sherry
Author Details:
Sherry Adkins, RN, MSN, CNS, ANP-C, Nurse Practitioner Fellow, M.D. Anderson Cancer Center, Houston, Texas, USA, email: saa2480@earthlink.net
Abstract:
Clinical/Evidence Based Practice: Obesity has been shown to be a well-established prognostic factor for several hormone-related cancers. However, the role that obesity plays in ovarian cancer has been inconsistently reported in the literature. Understanding the factors that may increase the risk for ovarian cancer recurrence and death is important for oncology nursing practice. Nursing interventions including risk-factor counseling and education regarding lifestyle modifications may decrease ovarian cancer morbidity and mortality. A review of the evidence is necessary to guide nursing practice. The purpose of this review of the literature was to determine if obesity is a prognostic factor for ovarian cancer. This systematic review included all pertinent studies that assessed the role that obesity plays in regards to disease-free and overall survival in ovarian cancer patients. Ten studies from the years 2002 to 2008 were reviewed. The role that obesity plays in regards to survival in ovarian cancer is not conclusive. This review determined that there was an association between obesity and disease-free and overall survival in ovarian cancer in seven of the ten studies. However, not all studies considered important confounding variables such as FIGO stage, tumor grade and histology, residual disease, type of chemotherapy, presence of ascites, and performance status. Many of the studies used self-reported height and weight, which is problematic. This review did elucidate the possibility that obese patients may be receiving suboptimal doses of chemotherapy due to current standard calculation measures It is important to further study the role that obesity plays in ovarian cancer survival. Future studies should consider the confounding variables previously mentioned. There is also a need for further studies regarding the dosing of chemotherapy in the obese population in order to achieve maximum benefit and minimal harm. Although the evidence in regards to the role that obesity plays in survival is not conclusive at this time, there is a tremendous amount of evidence regarding the deleterious effect that obesity plays in other types of cancer, diabetes, and cardiovascular disease. Nursing has the opportunity to impact the overall health of the obese population through education and support of patients in their weight loss endeavors.
Repository Posting Date:
27-Oct-2011
Date of Publication:
27-Oct-2011
Conference Date:
2009
Conference Name:
34th Annual Oncology Nursing Society Congress
Conference Host:
Oncology Nursing Society
Conference Location:
San Antonio, Texas, USA
Note:
This is an abstract-only submission. If the author has submitted a full-text item based on this abstract, you may find it by browsing the Virginia Henderson Global Nursing e-Repository by author. If author contact information is available in this abstract, please feel free to contact him or her with your queries regarding this submission. Alternatively, please contact the conference host, journal, or publisher (according to the circumstance) for further details regarding this item. If a citation is listed in this record, the item has been published and is available via open-access avenues or a journal/database subscription. Contact your library for assistance in obtaining the as-published article.

Full metadata record

DC FieldValue Language
dc.type.categoryAbstracten_US
dc.typePresentationen_GB
dc.titleIs Obesity a Prognostic Indicator for Ovarian Cancer?: A Systematic Review of the Literatureen_GB
dc.contributor.authorAdkins, Sherryen_US
dc.author.detailsSherry Adkins, RN, MSN, CNS, ANP-C, Nurse Practitioner Fellow, M.D. Anderson Cancer Center, Houston, Texas, USA, email: saa2480@earthlink.neten_US
dc.identifier.urihttp://hdl.handle.net/10755/164916-
dc.description.abstractClinical/Evidence Based Practice: Obesity has been shown to be a well-established prognostic factor for several hormone-related cancers. However, the role that obesity plays in ovarian cancer has been inconsistently reported in the literature. Understanding the factors that may increase the risk for ovarian cancer recurrence and death is important for oncology nursing practice. Nursing interventions including risk-factor counseling and education regarding lifestyle modifications may decrease ovarian cancer morbidity and mortality. A review of the evidence is necessary to guide nursing practice. The purpose of this review of the literature was to determine if obesity is a prognostic factor for ovarian cancer. This systematic review included all pertinent studies that assessed the role that obesity plays in regards to disease-free and overall survival in ovarian cancer patients. Ten studies from the years 2002 to 2008 were reviewed. The role that obesity plays in regards to survival in ovarian cancer is not conclusive. This review determined that there was an association between obesity and disease-free and overall survival in ovarian cancer in seven of the ten studies. However, not all studies considered important confounding variables such as FIGO stage, tumor grade and histology, residual disease, type of chemotherapy, presence of ascites, and performance status. Many of the studies used self-reported height and weight, which is problematic. This review did elucidate the possibility that obese patients may be receiving suboptimal doses of chemotherapy due to current standard calculation measures It is important to further study the role that obesity plays in ovarian cancer survival. Future studies should consider the confounding variables previously mentioned. There is also a need for further studies regarding the dosing of chemotherapy in the obese population in order to achieve maximum benefit and minimal harm. Although the evidence in regards to the role that obesity plays in survival is not conclusive at this time, there is a tremendous amount of evidence regarding the deleterious effect that obesity plays in other types of cancer, diabetes, and cardiovascular disease. Nursing has the opportunity to impact the overall health of the obese population through education and support of patients in their weight loss endeavors.en_GB
dc.date.available2011-10-27T12:09:15Z-
dc.date.issued2011-10-27en_GB
dc.date.accessioned2011-10-27T12:09:15Z-
dc.conference.date2009en_US
dc.conference.name34th Annual Oncology Nursing Society Congressen_US
dc.conference.hostOncology Nursing Societyen_US
dc.conference.locationSan Antonio, Texas, USAen_US
dc.description.noteThis is an abstract-only submission. If the author has submitted a full-text item based on this abstract, you may find it by browsing the Virginia Henderson Global Nursing e-Repository by author. If author contact information is available in this abstract, please feel free to contact him or her with your queries regarding this submission. Alternatively, please contact the conference host, journal, or publisher (according to the circumstance) for further details regarding this item. If a citation is listed in this record, the item has been published and is available via open-access avenues or a journal/database subscription. Contact your library for assistance in obtaining the as-published article.-
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