A longitudinal evaluation of oral mucositis from onset to healing in patients receiving intensity-modulated radiation therapy with/without chemotherapy

2.50
Hdl Handle:
http://hdl.handle.net/10755/164954
Category:
Abstract
Type:
Presentation
Title:
A longitudinal evaluation of oral mucositis from onset to healing in patients receiving intensity-modulated radiation therapy with/without chemotherapy
Author(s):
Dodd, Marylin; Cho, Maria; Miaskowski, Christine; Jeanne Quivey, Jeanne
Author Details:
Marylin Dodd, RN, PhD, Professor, University of California San Francisco, San Francisco, California, USA, email: marylin.dodd@nursing.ucsf.edu; Maria Cho, RN, PhD; Christine Miaskowski, RN, PhD; Jeanne Quivey, MD
Abstract:
Research Study: Oral mucositis is a major side effect of RT +/- CTX to the head and neck. A variety of instruments and techniques have been used to quantify oral cavity changes during treatment. Few studies have reported on the evaluation of oral mucositis using both subjective and objective methods. secondary aim in our study testing an innovative mouthwash is to increase our understanding of using subjective and objective methods for measuring oral mucositis, functional status, and weight changes over time. Patients reported functional status, pain and investigators measured oral mucositis and weight at four times (beginning of RT [T1], onset of mucositis [T2], end of RT [T3], and healing of mucositis [T4]) over a 10 - 15 week period, using the Karnofsky Performance Status [KPS]) and the Oral Mucositis Assessment Scale (OMAS). The OMAS measures researcher-evaluated ulceration/ pseudomembrane formation and erythema in specific sites in the mouth, and self-report by patients, rating severity of mouth pain, ability to swallow and chew. Of 51 head and neck cancer patients enrolled, 3 never developed mucositis. Mean days to onset of mucositis was 15.58 (SD 6.85), and mean days to healing of mucositis was 77.86 (SD 40.1). Subjective pain, chewing, and swallowing scores were positively correlated with each other (r= .31 - .73, p<.05) and objective oral mucositis scores were positively correlated with each other (r= .49 - .77, p<.01), however, no significant correlations were obtained between the subjective and objective scores. In both the RT-only group as well as the RT+CTX group, weight significantly decreased from T1 to T4, and KPS significantly decreased from T1 to T3. RT+CTX patients showed lower KPS and greater weight loss from T1 to T4 (X=10lbs) compared to the RT-only group (X=3 lbs), but neither was significantly different. During RT+CTX, patients need more supportive care to maintain functional status and avoid weight loss. Lack of correlations between the subjective and objective scores is interesting in that they are measuring something quite different, which may provide some insight into underlying mechanisms.
Repository Posting Date:
27-Oct-2011
Date of Publication:
27-Oct-2011
Conference Date:
2009
Conference Name:
34th Annual Oncology Nursing Society Congress
Conference Host:
Oncology Nursing Society
Conference Location:
San Antonio, Texas, USA
Sponsors:
Funding Sources: National Institutes of Health/National Cancer Institute.
Note:
This is an abstract-only submission. If the author has submitted a full-text item based on this abstract, you may find it by browsing the Virginia Henderson Global Nursing e-Repository by author. If author contact information is available in this abstract, please feel free to contact him or her with your queries regarding this submission. Alternatively, please contact the conference host, journal, or publisher (according to the circumstance) for further details regarding this item. If a citation is listed in this record, the item has been published and is available via open-access avenues or a journal/database subscription. Contact your library for assistance in obtaining the as-published article.

Full metadata record

DC FieldValue Language
dc.type.categoryAbstracten_US
dc.typePresentationen_GB
dc.titleA longitudinal evaluation of oral mucositis from onset to healing in patients receiving intensity-modulated radiation therapy with/without chemotherapyen_GB
dc.contributor.authorDodd, Marylinen_US
dc.contributor.authorCho, Mariaen_US
dc.contributor.authorMiaskowski, Christineen_US
dc.contributor.authorJeanne Quivey, Jeanneen_US
dc.author.detailsMarylin Dodd, RN, PhD, Professor, University of California San Francisco, San Francisco, California, USA, email: marylin.dodd@nursing.ucsf.edu; Maria Cho, RN, PhD; Christine Miaskowski, RN, PhD; Jeanne Quivey, MDen_US
dc.identifier.urihttp://hdl.handle.net/10755/164954-
dc.description.abstractResearch Study: Oral mucositis is a major side effect of RT +/- CTX to the head and neck. A variety of instruments and techniques have been used to quantify oral cavity changes during treatment. Few studies have reported on the evaluation of oral mucositis using both subjective and objective methods. secondary aim in our study testing an innovative mouthwash is to increase our understanding of using subjective and objective methods for measuring oral mucositis, functional status, and weight changes over time. Patients reported functional status, pain and investigators measured oral mucositis and weight at four times (beginning of RT [T1], onset of mucositis [T2], end of RT [T3], and healing of mucositis [T4]) over a 10 - 15 week period, using the Karnofsky Performance Status [KPS]) and the Oral Mucositis Assessment Scale (OMAS). The OMAS measures researcher-evaluated ulceration/ pseudomembrane formation and erythema in specific sites in the mouth, and self-report by patients, rating severity of mouth pain, ability to swallow and chew. Of 51 head and neck cancer patients enrolled, 3 never developed mucositis. Mean days to onset of mucositis was 15.58 (SD 6.85), and mean days to healing of mucositis was 77.86 (SD 40.1). Subjective pain, chewing, and swallowing scores were positively correlated with each other (r= .31 - .73, p&lt;.05) and objective oral mucositis scores were positively correlated with each other (r= .49 - .77, p&lt;.01), however, no significant correlations were obtained between the subjective and objective scores. In both the RT-only group as well as the RT+CTX group, weight significantly decreased from T1 to T4, and KPS significantly decreased from T1 to T3. RT+CTX patients showed lower KPS and greater weight loss from T1 to T4 (X=10lbs) compared to the RT-only group (X=3 lbs), but neither was significantly different. During RT+CTX, patients need more supportive care to maintain functional status and avoid weight loss. Lack of correlations between the subjective and objective scores is interesting in that they are measuring something quite different, which may provide some insight into underlying mechanisms.en_GB
dc.date.available2011-10-27T12:09:56Z-
dc.date.issued2011-10-27en_GB
dc.date.accessioned2011-10-27T12:09:56Z-
dc.conference.date2009en_US
dc.conference.name34th Annual Oncology Nursing Society Congressen_US
dc.conference.hostOncology Nursing Societyen_US
dc.conference.locationSan Antonio, Texas, USAen_US
dc.description.sponsorshipFunding Sources: National Institutes of Health/National Cancer Institute.-
dc.description.noteThis is an abstract-only submission. If the author has submitted a full-text item based on this abstract, you may find it by browsing the Virginia Henderson Global Nursing e-Repository by author. If author contact information is available in this abstract, please feel free to contact him or her with your queries regarding this submission. Alternatively, please contact the conference host, journal, or publisher (according to the circumstance) for further details regarding this item. If a citation is listed in this record, the item has been published and is available via open-access avenues or a journal/database subscription. Contact your library for assistance in obtaining the as-published article.-
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