CANCER PREVENTION AND EARLY DETECTION OF GASTRIC CANCER: THE ROLE OF THE EARLY ONSET AND FAMILIAL GASTRIC CANCER REGISTRY

2.50
Hdl Handle:
http://hdl.handle.net/10755/165099
Category:
Abstract
Type:
Presentation
Title:
CANCER PREVENTION AND EARLY DETECTION OF GASTRIC CANCER: THE ROLE OF THE EARLY ONSET AND FAMILIAL GASTRIC CANCER REGISTRY
Author(s):
Randazzo, Jennifer; Harlan, Megan; Sheehy, Elaine; Shah, Manish
Author Details:
Jennifer Randazzo, RN, Clinical Research Nurse, Memorial Sloan-Kettering Cancer Center, New York, New York, USA, email: randazzj@mskcc.org; Megan Harlan, CGC, MS; Elaine Sheehy, BS; Manish Shah, MD
Abstract:
Gastric cancer is the second leading cause of cancer-related mortality world-wide. US minority and underserved populations have a significantly worse prognosis that cannot be explained solely by external factors such as diet, co-morbidities, or access to health care. The role that genetics plays in gastric cancer is also not fully understood. Up to 15% of gastric cancer cases are related to an inherited component, of which 1/3 are due to a mutation in CDH1, the genetic cause of Hereditary Diffuse Gastric Cancer. In January 2006, the Early Onset and Familial Gastric Cancer Registry was established at this Comprehensive Cancer Center to compile information on individuals with a personal history of gastric or gastro-esophageal (GEJ) cancer and their at-risk family members. Eligible persons are either æEarly OnsetÆ (EOG), diagnosis age < 50, or æFamilialÆ (FGC), one first or two second degree relatives with disease. Aim: To prospectively collect epidemiologic data and create a matched tissue and DNA repository, with an emphasis on minority recruitment. With this matched prospective resource we can: identify sporadic CDH1 mutations, explore for other genes associated with hereditable gastric cancer via linkage studies, explore for a trigger to developing the disease in CDH1 mutation carriers, and study the linkage between CDH1 mutations and other malignancies. Method: All who agree to participate are asked to complete a family history and gastric cancer questionnaire, and to refer family members for participating. This questionnaire includes personal medical history and dietary habits. After enrollment, patients may choose to contribute a blood and/or tissue sample for the tissue repository and meet with a genetic counselor to discuss the risks, benefits and limitations of genetic testing. Since establishing the registry, 83 participants have enrolled, 59 of which are EOG and 24 that are FGC. We have opened a third cohort to include those not eligible for either of the two primary cohorts. This group is our æcontrol armÆ and consists of 7 members thus far. The information gathered by this registry can be applied to screening and prevention guidelines which will impact the overall healthcare of individuals at high-risk.
Repository Posting Date:
27-Oct-2011
Date of Publication:
27-Oct-2011
Conference Date:
2007
Conference Name:
32nd Annual Oncology Nursing Society Congress
Conference Host:
Oncology Nursing Society
Conference Location:
Las Vegas, Nevada, USA
Note:
This is an abstract-only submission. If the author has submitted a full-text item based on this abstract, you may find it by browsing the Virginia Henderson Global Nursing e-Repository by author. If author contact information is available in this abstract, please feel free to contact him or her with your queries regarding this submission. Alternatively, please contact the conference host, journal, or publisher (according to the circumstance) for further details regarding this item. If a citation is listed in this record, the item has been published and is available via open-access avenues or a journal/database subscription. Contact your library for assistance in obtaining the as-published article.

Full metadata record

DC FieldValue Language
dc.type.categoryAbstracten_US
dc.typePresentationen_GB
dc.titleCANCER PREVENTION AND EARLY DETECTION OF GASTRIC CANCER: THE ROLE OF THE EARLY ONSET AND FAMILIAL GASTRIC CANCER REGISTRYen_GB
dc.contributor.authorRandazzo, Jenniferen_US
dc.contributor.authorHarlan, Meganen_US
dc.contributor.authorSheehy, Elaineen_US
dc.contributor.authorShah, Manishen_US
dc.author.detailsJennifer Randazzo, RN, Clinical Research Nurse, Memorial Sloan-Kettering Cancer Center, New York, New York, USA, email: randazzj@mskcc.org; Megan Harlan, CGC, MS; Elaine Sheehy, BS; Manish Shah, MDen_US
dc.identifier.urihttp://hdl.handle.net/10755/165099-
dc.description.abstractGastric cancer is the second leading cause of cancer-related mortality world-wide. US minority and underserved populations have a significantly worse prognosis that cannot be explained solely by external factors such as diet, co-morbidities, or access to health care. The role that genetics plays in gastric cancer is also not fully understood. Up to 15% of gastric cancer cases are related to an inherited component, of which 1/3 are due to a mutation in CDH1, the genetic cause of Hereditary Diffuse Gastric Cancer. In January 2006, the Early Onset and Familial Gastric Cancer Registry was established at this Comprehensive Cancer Center to compile information on individuals with a personal history of gastric or gastro-esophageal (GEJ) cancer and their at-risk family members. Eligible persons are either &aelig;Early Onset&AElig; (EOG), diagnosis age &lt; 50, or &aelig;Familial&AElig; (FGC), one first or two second degree relatives with disease. Aim: To prospectively collect epidemiologic data and create a matched tissue and DNA repository, with an emphasis on minority recruitment. With this matched prospective resource we can: identify sporadic CDH1 mutations, explore for other genes associated with hereditable gastric cancer via linkage studies, explore for a trigger to developing the disease in CDH1 mutation carriers, and study the linkage between CDH1 mutations and other malignancies. Method: All who agree to participate are asked to complete a family history and gastric cancer questionnaire, and to refer family members for participating. This questionnaire includes personal medical history and dietary habits. After enrollment, patients may choose to contribute a blood and/or tissue sample for the tissue repository and meet with a genetic counselor to discuss the risks, benefits and limitations of genetic testing. Since establishing the registry, 83 participants have enrolled, 59 of which are EOG and 24 that are FGC. We have opened a third cohort to include those not eligible for either of the two primary cohorts. This group is our &aelig;control arm&AElig; and consists of 7 members thus far. The information gathered by this registry can be applied to screening and prevention guidelines which will impact the overall healthcare of individuals at high-risk.en_GB
dc.date.available2011-10-27T12:12:30Z-
dc.date.issued2011-10-27en_GB
dc.date.accessioned2011-10-27T12:12:30Z-
dc.conference.date2007en_US
dc.conference.name32nd Annual Oncology Nursing Society Congressen_US
dc.conference.hostOncology Nursing Societyen_US
dc.conference.locationLas Vegas, Nevada, USAen_US
dc.description.noteThis is an abstract-only submission. If the author has submitted a full-text item based on this abstract, you may find it by browsing the Virginia Henderson Global Nursing e-Repository by author. If author contact information is available in this abstract, please feel free to contact him or her with your queries regarding this submission. Alternatively, please contact the conference host, journal, or publisher (according to the circumstance) for further details regarding this item. If a citation is listed in this record, the item has been published and is available via open-access avenues or a journal/database subscription. Contact your library for assistance in obtaining the as-published article.-
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