EFFICACY OF GABAPENTIN ON PRURITUS INDUCED BY INTERLEUKIN-2 (IL-2) TREATMENT IN PATIENTS WITH METASTATIC RENAL CELL CARCINOMA AND MELANOMA

2.50
Hdl Handle:
http://hdl.handle.net/10755/165113
Category:
Abstract
Type:
Presentation
Title:
EFFICACY OF GABAPENTIN ON PRURITUS INDUCED BY INTERLEUKIN-2 (IL-2) TREATMENT IN PATIENTS WITH METASTATIC RENAL CELL CARCINOMA AND MELANOMA
Author(s):
Rusciano, Valerie; Lee, Sung Ho; Dutcher, Janice
Author Details:
Valerie Rusciano, RN, Our Lady of Mercy Medical Center, Bronx, New York, USA, email: veejay924@aol.com; Sung Ho Lee, MD; Janice Dutcher, MD
Abstract:
IL-2 treatment causes pruritus. The role of histamine contributing to pruritus is controversial, and eosinophilia induced by IL-2 does not seem to correlate with the pruritus. Direct stimulation of pain nerve fibers, such as A-delta and C fibers by the cytokines induced by IL-2 treatment has been proposed as a possible cause. We have used Gabapentin to stabilize the nerve membrane or nerve synapses to impact on the pruritus. To provide the oncology nurse with insight into the identification and novel treatment options for pruritus in patients treated with IL-2 for metastatic renal cell carcinoma and melanoma. Based on the mechanism of action of Gabapentin, we hypothesized that it could alleviate pruritus. Direct interview and review concurrent follow up notes as well as IRB approved questionnaire was utilized. 54 patients treated with IL- 2 from January 2005 to December 2006 were screened. Among 30 patients who complained of pruritus, 17 were given Gabapentin. We quantified these 17 patientÆs pruritus according to CTCAE 3.0 criteria, before and after Gabapentin. The CTCAE grading scale i1 0-3, from none, localized, widespread pruritus interfering with daily activities. Data was analyzed with paired student T-test using SPSS 13.0 for data analysis. Mean age was 56. 12 male and 5 female. 15 patients had renal cell carcinoma and 2 had melanoma. Gabapentin was started in hospital in 9 patients and outpatient in 8. Mean initial dose of Gabapentin was 865 mg/day and the mean time for Gabapentin to provide symptom relief was 1.088 hours after each dose. According to CTCAE scale, the mean pruritus before Gabapentin was 2.41 and it decreased to 0.65 after Gabapentin treatment. Paired student T-test for the difference of means before and after treatment was statistically significant (p<0.0005). In conclusion, pruritus induced by IL-2 infusion responds well to Gabapentin. Although other confounding causes of pruritus cannot be excluded, the major mechanism is likely due to direct or indirect effect of IL-2, which then stimulates the nerve fibers. Thus, we propose to educate the oncology nurses about Gabapentin as an effective treatment against pruritus induced by IL-2.
Repository Posting Date:
27-Oct-2011
Date of Publication:
27-Oct-2011
Conference Date:
2007
Conference Name:
32nd Annual Oncology Nursing Society Congress
Conference Host:
Oncology Nursing Society
Conference Location:
Las Vegas, Nevada, USA
Note:
This is an abstract-only submission. If the author has submitted a full-text item based on this abstract, you may find it by browsing the Virginia Henderson Global Nursing e-Repository by author. If author contact information is available in this abstract, please feel free to contact him or her with your queries regarding this submission. Alternatively, please contact the conference host, journal, or publisher (according to the circumstance) for further details regarding this item. If a citation is listed in this record, the item has been published and is available via open-access avenues or a journal/database subscription. Contact your library for assistance in obtaining the as-published article.

Full metadata record

DC FieldValue Language
dc.type.categoryAbstracten_US
dc.typePresentationen_GB
dc.titleEFFICACY OF GABAPENTIN ON PRURITUS INDUCED BY INTERLEUKIN-2 (IL-2) TREATMENT IN PATIENTS WITH METASTATIC RENAL CELL CARCINOMA AND MELANOMAen_GB
dc.contributor.authorRusciano, Valerieen_US
dc.contributor.authorLee, Sung Hoen_US
dc.contributor.authorDutcher, Janiceen_US
dc.author.detailsValerie Rusciano, RN, Our Lady of Mercy Medical Center, Bronx, New York, USA, email: veejay924@aol.com; Sung Ho Lee, MD; Janice Dutcher, MDen_US
dc.identifier.urihttp://hdl.handle.net/10755/165113-
dc.description.abstractIL-2 treatment causes pruritus. The role of histamine contributing to pruritus is controversial, and eosinophilia induced by IL-2 does not seem to correlate with the pruritus. Direct stimulation of pain nerve fibers, such as A-delta and C fibers by the cytokines induced by IL-2 treatment has been proposed as a possible cause. We have used Gabapentin to stabilize the nerve membrane or nerve synapses to impact on the pruritus. To provide the oncology nurse with insight into the identification and novel treatment options for pruritus in patients treated with IL-2 for metastatic renal cell carcinoma and melanoma. Based on the mechanism of action of Gabapentin, we hypothesized that it could alleviate pruritus. Direct interview and review concurrent follow up notes as well as IRB approved questionnaire was utilized. 54 patients treated with IL- 2 from January 2005 to December 2006 were screened. Among 30 patients who complained of pruritus, 17 were given Gabapentin. We quantified these 17 patient&AElig;s pruritus according to CTCAE 3.0 criteria, before and after Gabapentin. The CTCAE grading scale i1 0-3, from none, localized, widespread pruritus interfering with daily activities. Data was analyzed with paired student T-test using SPSS 13.0 for data analysis. Mean age was 56. 12 male and 5 female. 15 patients had renal cell carcinoma and 2 had melanoma. Gabapentin was started in hospital in 9 patients and outpatient in 8. Mean initial dose of Gabapentin was 865 mg/day and the mean time for Gabapentin to provide symptom relief was 1.088 hours after each dose. According to CTCAE scale, the mean pruritus before Gabapentin was 2.41 and it decreased to 0.65 after Gabapentin treatment. Paired student T-test for the difference of means before and after treatment was statistically significant (p&lt;0.0005). In conclusion, pruritus induced by IL-2 infusion responds well to Gabapentin. Although other confounding causes of pruritus cannot be excluded, the major mechanism is likely due to direct or indirect effect of IL-2, which then stimulates the nerve fibers. Thus, we propose to educate the oncology nurses about Gabapentin as an effective treatment against pruritus induced by IL-2.en_GB
dc.date.available2011-10-27T12:12:45Z-
dc.date.issued2011-10-27en_GB
dc.date.accessioned2011-10-27T12:12:45Z-
dc.conference.date2007en_US
dc.conference.name32nd Annual Oncology Nursing Society Congressen_US
dc.conference.hostOncology Nursing Societyen_US
dc.conference.locationLas Vegas, Nevada, USAen_US
dc.description.noteThis is an abstract-only submission. If the author has submitted a full-text item based on this abstract, you may find it by browsing the Virginia Henderson Global Nursing e-Repository by author. If author contact information is available in this abstract, please feel free to contact him or her with your queries regarding this submission. Alternatively, please contact the conference host, journal, or publisher (according to the circumstance) for further details regarding this item. If a citation is listed in this record, the item has been published and is available via open-access avenues or a journal/database subscription. Contact your library for assistance in obtaining the as-published article.-
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