2.50
Hdl Handle:
http://hdl.handle.net/10755/165141
Category:
Abstract
Type:
Presentation
Title:
AN INNOVATIVE DESIGN FOR IMMEDIATE SUBJECT ACCRUAL FOR RESEARCH
Author(s):
Lemler, Suzanne; Thompson, Barbara; Rush-Taylor, Anita; Murphy, Vivian; Christmon, Darlene; Coleman, Nicki
Author Details:
Suzanne Lemler, RN, CCRP, Research Nurse Coordinator, Indiana University, Indianapolis, Indiana, USA, email: sulemler@iupui.edu; Barbara Thompson; Anita Rush-Taylor; Vivian Murphy; Darlene Christmon; Nicki Coleman
Abstract:
Topic: The ability to recruit and conduct a study on a large number of subjects in a clinical trial in an efficient amount of time has been an ongoing challenge. Purpose: In order to evaluate the role of polymorphic differences in genes important in the angiogenesis pathway in breast cancer, 1000 women (500 women with history of breast cancer and 500 controls) were required. Although subjects with cancer can be recruited from clinic populations, recruitment of controls is challenging. We estimated total accrual would take months or years at great expense. To minimize resources and to optimize time, Indiana University's (IU) oncology nursing staff, supported by an oncology fellow and a patient advocate, coordinated to obtain subjects for the trial in a single day. Methods: A 5-page questionnaire (consisting of risk factors, medications, and demographic information) and a 9ml tube of blood (for future DNA extraction and genotyping) were required. Funding sources were recruited to obtain phlebotomy supplies, food for the volunteers, volunteer T-shirts, etc. Location and flow of the study were designed and mapped for the single day event, which took place 5 blocks from the Indianapolis Susan G. Komen Race for the Cure. Over 160 volunteers from a variety of disciplines were recruited to help conduct the trial. Several newsletters were created and an orientation session was presented for volunteer preparation. Findings: On Saturday, April 16, 2005, a total of 855 subjects successfully completed the study over a 5.5-hour period. The majority of women enrolled did not have a history of breast cancer (ratio 7 to 1); therefore, recruitment to complete enrollment for breast cancer survivors continued in the clinics for 2 months with 389 additional subjects (average of 10 subjects per day) enrolled with a final count of 1244 subjects for the entire project. In conclusion, IU's nursing staff created a model for collecting large groups of subjects in hours rather than months or years. With detailed logistical planning and effort by a committed group of volunteers, biologic samples from a large group of breast cancer survivors and controls can be collected within several hours.
Repository Posting Date:
27-Oct-2011
Date of Publication:
27-Oct-2011
Conference Date:
2006
Conference Name:
31st Annual Oncology Nursing Society Congress
Conference Host:
Oncology Nursing Society
Conference Location:
Boston, Massachusetts, USA
Sponsors:
Funding Sources: AstraZeneca, Pfizer, Novartis, Genentech, Roche, MGI.
Note:
This is an abstract-only submission. If the author has submitted a full-text item based on this abstract, you may find it by browsing the Virginia Henderson Global Nursing e-Repository by author. If author contact information is available in this abstract, please feel free to contact him or her with your queries regarding this submission. Alternatively, please contact the conference host, journal, or publisher (according to the circumstance) for further details regarding this item. If a citation is listed in this record, the item has been published and is available via open-access avenues or a journal/database subscription. Contact your library for assistance in obtaining the as-published article.

Full metadata record

DC FieldValue Language
dc.type.categoryAbstracten_US
dc.typePresentationen_GB
dc.titleAN INNOVATIVE DESIGN FOR IMMEDIATE SUBJECT ACCRUAL FOR RESEARCHen_GB
dc.contributor.authorLemler, Suzanneen_US
dc.contributor.authorThompson, Barbaraen_US
dc.contributor.authorRush-Taylor, Anitaen_US
dc.contributor.authorMurphy, Vivianen_US
dc.contributor.authorChristmon, Darleneen_US
dc.contributor.authorColeman, Nickien_US
dc.author.detailsSuzanne Lemler, RN, CCRP, Research Nurse Coordinator, Indiana University, Indianapolis, Indiana, USA, email: sulemler@iupui.edu; Barbara Thompson; Anita Rush-Taylor; Vivian Murphy; Darlene Christmon; Nicki Colemanen_US
dc.identifier.urihttp://hdl.handle.net/10755/165141-
dc.description.abstractTopic: The ability to recruit and conduct a study on a large number of subjects in a clinical trial in an efficient amount of time has been an ongoing challenge. Purpose: In order to evaluate the role of polymorphic differences in genes important in the angiogenesis pathway in breast cancer, 1000 women (500 women with history of breast cancer and 500 controls) were required. Although subjects with cancer can be recruited from clinic populations, recruitment of controls is challenging. We estimated total accrual would take months or years at great expense. To minimize resources and to optimize time, Indiana University's (IU) oncology nursing staff, supported by an oncology fellow and a patient advocate, coordinated to obtain subjects for the trial in a single day. Methods: A 5-page questionnaire (consisting of risk factors, medications, and demographic information) and a 9ml tube of blood (for future DNA extraction and genotyping) were required. Funding sources were recruited to obtain phlebotomy supplies, food for the volunteers, volunteer T-shirts, etc. Location and flow of the study were designed and mapped for the single day event, which took place 5 blocks from the Indianapolis Susan G. Komen Race for the Cure. Over 160 volunteers from a variety of disciplines were recruited to help conduct the trial. Several newsletters were created and an orientation session was presented for volunteer preparation. Findings: On Saturday, April 16, 2005, a total of 855 subjects successfully completed the study over a 5.5-hour period. The majority of women enrolled did not have a history of breast cancer (ratio 7 to 1); therefore, recruitment to complete enrollment for breast cancer survivors continued in the clinics for 2 months with 389 additional subjects (average of 10 subjects per day) enrolled with a final count of 1244 subjects for the entire project. In conclusion, IU's nursing staff created a model for collecting large groups of subjects in hours rather than months or years. With detailed logistical planning and effort by a committed group of volunteers, biologic samples from a large group of breast cancer survivors and controls can be collected within several hours.en_GB
dc.date.available2011-10-27T12:13:15Z-
dc.date.issued2011-10-27en_GB
dc.date.accessioned2011-10-27T12:13:15Z-
dc.conference.date2006en_US
dc.conference.name31st Annual Oncology Nursing Society Congressen_US
dc.conference.hostOncology Nursing Societyen_US
dc.conference.locationBoston, Massachusetts, USAen_US
dc.description.sponsorshipFunding Sources: AstraZeneca, Pfizer, Novartis, Genentech, Roche, MGI.-
dc.description.noteThis is an abstract-only submission. If the author has submitted a full-text item based on this abstract, you may find it by browsing the Virginia Henderson Global Nursing e-Repository by author. If author contact information is available in this abstract, please feel free to contact him or her with your queries regarding this submission. Alternatively, please contact the conference host, journal, or publisher (according to the circumstance) for further details regarding this item. If a citation is listed in this record, the item has been published and is available via open-access avenues or a journal/database subscription. Contact your library for assistance in obtaining the as-published article.-
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