EXAMINING THE RELATIONSHIPS BETWEEN CLINICAL VARIABLES, QUALITY OF LIFE AND FATIGUE IN PATIENTS WITH MULTIPLE MYELOMA.

2.50
Hdl Handle:
http://hdl.handle.net/10755/165183
Category:
Abstract
Type:
Presentation
Title:
EXAMINING THE RELATIONSHIPS BETWEEN CLINICAL VARIABLES, QUALITY OF LIFE AND FATIGUE IN PATIENTS WITH MULTIPLE MYELOMA.
Author(s):
Booker, Reanne; Olson, Karin; Whyte, Darlene
Author Details:
Reanne Booker, RN BSCN MN, Nurse Practitioner, Tom Baker Cancer Center/Alberta Cancer Board, Calgary, Alberta, Canada, email: rbooker@ualberta.ca; Karin Olson, RN, PhD; Faculty of Nursing, University of Alberta, Edmonton, Canada; Darlene Whyte, RN, BN
Abstract:
Fatigue is one of the most commonly reported symptoms in patients with cancer and is almost certain to occur at some point along the illness trajectory in patients with multiple myeloma (MM). Fatigue remains a multifaceted symptom. Although most research has focused on the role of anemia, there is growing evidence that other processes, such as inflammation, may contribute to the development of fatigue. A greater understanding of the pathophysiology of fatigue in multiple myeloma may provide important information about individual experience and lead to improved symptom management and quality of life in these individuals. The purpose of this study was to begin an exploration of factors related to disease and treatment in MM that contribute to the development of fatigue in these individuals. The objective of this study was: 1) To examine the relationships between clinical variables (hemoglobin, serum albumin, C-reactive protein), fatigue and quality of life in individuals with multiple myeloma. There is increasing evidence to support a neuroimmunological role in the development of cancer related symptoms. For example, over/ aberrant expression of proinflammatory cytokines has been identified as an essential component of tumor progression/ proliferation. It is hypothesized that these same cytokines also contribute to the development of cancer related symptoms including lean tissue loss, poor performance status, fatigue and anemia. Further evaluation of the pathology of fatigue may lead to greater understanding of how patients respond to therapy and contribute to the development of new approaches to fatigue management. This study employed a descriptive exploratory design. Forty three patients were accrued. Instruments used to assess quality of life included the EORTC-QLQ-C30 and MY24 (a myeloma specific QOL module). Fatigue was assessed using the FACT-F. Data analysis included basic descriptive statistics, simple linear regression and multiple regression. Preliminary data analysis reveals negative correlations between hemoglobin and CRP, albumin and CRP and QOL and CRP. This suggests a possible role for inflammation in the development of cancer related fatigue and QOL. These findings support the need for further research into the mechanisms underlying cancer related fatigue with the greater goal of improving symptom management and patient quality of life.
Repository Posting Date:
27-Oct-2011
Date of Publication:
27-Oct-2011
Conference Date:
2007
Conference Name:
32nd Annual Oncology Nursing Society Congress
Conference Host:
Oncology Nursing Society
Conference Location:
Las Vegas, Nevada, USA
Note:
This is an abstract-only submission. If the author has submitted a full-text item based on this abstract, you may find it by browsing the Virginia Henderson Global Nursing e-Repository by author. If author contact information is available in this abstract, please feel free to contact him or her with your queries regarding this submission. Alternatively, please contact the conference host, journal, or publisher (according to the circumstance) for further details regarding this item. If a citation is listed in this record, the item has been published and is available via open-access avenues or a journal/database subscription. Contact your library for assistance in obtaining the as-published article.

Full metadata record

DC FieldValue Language
dc.type.categoryAbstracten_US
dc.typePresentationen_GB
dc.titleEXAMINING THE RELATIONSHIPS BETWEEN CLINICAL VARIABLES, QUALITY OF LIFE AND FATIGUE IN PATIENTS WITH MULTIPLE MYELOMA.en_GB
dc.contributor.authorBooker, Reanneen_US
dc.contributor.authorOlson, Karinen_US
dc.contributor.authorWhyte, Darleneen_US
dc.author.detailsReanne Booker, RN BSCN MN, Nurse Practitioner, Tom Baker Cancer Center/Alberta Cancer Board, Calgary, Alberta, Canada, email: rbooker@ualberta.ca; Karin Olson, RN, PhD; Faculty of Nursing, University of Alberta, Edmonton, Canada; Darlene Whyte, RN, BNen_US
dc.identifier.urihttp://hdl.handle.net/10755/165183-
dc.description.abstractFatigue is one of the most commonly reported symptoms in patients with cancer and is almost certain to occur at some point along the illness trajectory in patients with multiple myeloma (MM). Fatigue remains a multifaceted symptom. Although most research has focused on the role of anemia, there is growing evidence that other processes, such as inflammation, may contribute to the development of fatigue. A greater understanding of the pathophysiology of fatigue in multiple myeloma may provide important information about individual experience and lead to improved symptom management and quality of life in these individuals. The purpose of this study was to begin an exploration of factors related to disease and treatment in MM that contribute to the development of fatigue in these individuals. The objective of this study was: 1) To examine the relationships between clinical variables (hemoglobin, serum albumin, C-reactive protein), fatigue and quality of life in individuals with multiple myeloma. There is increasing evidence to support a neuroimmunological role in the development of cancer related symptoms. For example, over/ aberrant expression of proinflammatory cytokines has been identified as an essential component of tumor progression/ proliferation. It is hypothesized that these same cytokines also contribute to the development of cancer related symptoms including lean tissue loss, poor performance status, fatigue and anemia. Further evaluation of the pathology of fatigue may lead to greater understanding of how patients respond to therapy and contribute to the development of new approaches to fatigue management. This study employed a descriptive exploratory design. Forty three patients were accrued. Instruments used to assess quality of life included the EORTC-QLQ-C30 and MY24 (a myeloma specific QOL module). Fatigue was assessed using the FACT-F. Data analysis included basic descriptive statistics, simple linear regression and multiple regression. Preliminary data analysis reveals negative correlations between hemoglobin and CRP, albumin and CRP and QOL and CRP. This suggests a possible role for inflammation in the development of cancer related fatigue and QOL. These findings support the need for further research into the mechanisms underlying cancer related fatigue with the greater goal of improving symptom management and patient quality of life.en_GB
dc.date.available2011-10-27T12:14:00Z-
dc.date.issued2011-10-27en_GB
dc.date.accessioned2011-10-27T12:14:00Z-
dc.conference.date2007en_US
dc.conference.name32nd Annual Oncology Nursing Society Congressen_US
dc.conference.hostOncology Nursing Societyen_US
dc.conference.locationLas Vegas, Nevada, USAen_US
dc.description.noteThis is an abstract-only submission. If the author has submitted a full-text item based on this abstract, you may find it by browsing the Virginia Henderson Global Nursing e-Repository by author. If author contact information is available in this abstract, please feel free to contact him or her with your queries regarding this submission. Alternatively, please contact the conference host, journal, or publisher (according to the circumstance) for further details regarding this item. If a citation is listed in this record, the item has been published and is available via open-access avenues or a journal/database subscription. Contact your library for assistance in obtaining the as-published article.-
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