2.50
Hdl Handle:
http://hdl.handle.net/10755/165294
Category:
Abstract
Type:
Presentation
Title:
MATH INTERVENTION FOR CHILDREN WITH ACUTE LYMPHOBLASTIC LEUKEMIA
Author(s):
Moore, Ida; Hockenberry, Marilyn; Kaemingk, Kris; Miketova, Petra
Author Details:
Ida Moore, RN, DNS, FAAN, The University of Arizona, College of Nursing, Tucson, Arizona, USA; Marilyn Hockenberry, RN, PhD, FAAN, Baylor College of Medicine, Houston, Texas, US; Kris Kaemingk, PhD; Petra Miketova, PhD
Abstract:
The study documents a mechanisms of chemotherapy-induced central nervous system (CNS) injury, and provide evidence for efficacy of a Math Intervention. The purpose was to test a math intervention for children diagnosed with acute lymphoblastic leukemia (ALL) who receive intrathecal chemotherapy and systemic intermediate dose methotrexate. The specific aims were to: 1. Determine if a Math Intervention prevents declines in math achievement scores in children with ALL; 2. Determine if a Math Intervention improves math abilities in children with documented declines in math abilities following CNS treatment, and 3. Investigate oxidative injury during CNS treatment. The conceptual model examined CNS treatment on CNS treatment effects on cell injury, effects of cell injury on cognitive and academic outcomes, and effect of a Math Intervention on academic math abilities. A prospective repeated measures design was used. Subjects were randomized to standard care or Math Intervention. 65 children with ALL and 15 healthy siblings were studied. Standardized measures of cognitive and academic abilities were administered at baseline (after completion of induction therapy; and 1, 2, and 3 year after ALL diagnosis. Cerebral spinal fluid (CSF) was collected at diagnosis and subsequently in conjunction with therapeutic lumbar punctures. Phospholipids were extracted from CSF (Floch et al), separated by normal phase HPLC with diode array detection. Oxidation was measured in the major membrane phospholipid, phosphatidycholine (PC). Unoxidized PC was detected at 206 nm, and oxidized PC was detected at 234 nm. The ratio of oxidized PC to un-oxidized PC was calculated. Data were evaluated using descriptive statistics, t-tests, and repeated measures analysis of variance. Math Intervention had a significant effect on math achievement scores of children who completed ALL treatment (F= 14.3; p < 0.01). Math intervention had a significant increase in math achievement scores in children receiving CNS treatment (p < 0.05). There were no significant differences in the oxidized PC ratio in diagnostic CSF samples among ALL risk groups. The oxidized PC index was significantly increased in CSF obtained during ALL treatment. Significant effects for risk group, treatment phase, and risk group by treatment phase interaction were found (p < 0.01).
Repository Posting Date:
27-Oct-2011
Date of Publication:
27-Oct-2011
Conference Date:
2005
Conference Name:
30th Annual Oncology Nursing Society Congress
Conference Host:
Oncology Nursing Society
Conference Location:
Orlando, Florida, USA
Sponsors:
Funding Sources: NR04905, HD37816; P20 NR007794; ONS Foundation through an unrestricted grant from Ortho Biotech Products, L.P.
Note:
This is an abstract-only submission. If the author has submitted a full-text item based on this abstract, you may find it by browsing the Virginia Henderson Global Nursing e-Repository by author. If author contact information is available in this abstract, please feel free to contact him or her with your queries regarding this submission. Alternatively, please contact the conference host, journal, or publisher (according to the circumstance) for further details regarding this item. If a citation is listed in this record, the item has been published and is available via open-access avenues or a journal/database subscription. Contact your library for assistance in obtaining the as-published article.

Full metadata record

DC FieldValue Language
dc.type.categoryAbstracten_US
dc.typePresentationen_GB
dc.titleMATH INTERVENTION FOR CHILDREN WITH ACUTE LYMPHOBLASTIC LEUKEMIAen_GB
dc.contributor.authorMoore, Idaen_US
dc.contributor.authorHockenberry, Marilynen_US
dc.contributor.authorKaemingk, Krisen_US
dc.contributor.authorMiketova, Petraen_US
dc.author.detailsIda Moore, RN, DNS, FAAN, The University of Arizona, College of Nursing, Tucson, Arizona, USA; Marilyn Hockenberry, RN, PhD, FAAN, Baylor College of Medicine, Houston, Texas, US; Kris Kaemingk, PhD; Petra Miketova, PhDen_US
dc.identifier.urihttp://hdl.handle.net/10755/165294-
dc.description.abstractThe study documents a mechanisms of chemotherapy-induced central nervous system (CNS) injury, and provide evidence for efficacy of a Math Intervention. The purpose was to test a math intervention for children diagnosed with acute lymphoblastic leukemia (ALL) who receive intrathecal chemotherapy and systemic intermediate dose methotrexate. The specific aims were to: 1. Determine if a Math Intervention prevents declines in math achievement scores in children with ALL; 2. Determine if a Math Intervention improves math abilities in children with documented declines in math abilities following CNS treatment, and 3. Investigate oxidative injury during CNS treatment. The conceptual model examined CNS treatment on CNS treatment effects on cell injury, effects of cell injury on cognitive and academic outcomes, and effect of a Math Intervention on academic math abilities. A prospective repeated measures design was used. Subjects were randomized to standard care or Math Intervention. 65 children with ALL and 15 healthy siblings were studied. Standardized measures of cognitive and academic abilities were administered at baseline (after completion of induction therapy; and 1, 2, and 3 year after ALL diagnosis. Cerebral spinal fluid (CSF) was collected at diagnosis and subsequently in conjunction with therapeutic lumbar punctures. Phospholipids were extracted from CSF (Floch et al), separated by normal phase HPLC with diode array detection. Oxidation was measured in the major membrane phospholipid, phosphatidycholine (PC). Unoxidized PC was detected at 206 nm, and oxidized PC was detected at 234 nm. The ratio of oxidized PC to un-oxidized PC was calculated. Data were evaluated using descriptive statistics, t-tests, and repeated measures analysis of variance. Math Intervention had a significant effect on math achievement scores of children who completed ALL treatment (F= 14.3; p &lt; 0.01). Math intervention had a significant increase in math achievement scores in children receiving CNS treatment (p &lt; 0.05). There were no significant differences in the oxidized PC ratio in diagnostic CSF samples among ALL risk groups. The oxidized PC index was significantly increased in CSF obtained during ALL treatment. Significant effects for risk group, treatment phase, and risk group by treatment phase interaction were found (p &lt; 0.01).en_GB
dc.date.available2011-10-27T12:15:58Z-
dc.date.issued2011-10-27en_GB
dc.date.accessioned2011-10-27T12:15:58Z-
dc.conference.date2005en_US
dc.conference.name30th Annual Oncology Nursing Society Congressen_US
dc.conference.hostOncology Nursing Societyen_US
dc.conference.locationOrlando, Florida, USAen_US
dc.description.sponsorshipFunding Sources: NR04905, HD37816; P20 NR007794; ONS Foundation through an unrestricted grant from Ortho Biotech Products, L.P.-
dc.description.noteThis is an abstract-only submission. If the author has submitted a full-text item based on this abstract, you may find it by browsing the Virginia Henderson Global Nursing e-Repository by author. If author contact information is available in this abstract, please feel free to contact him or her with your queries regarding this submission. Alternatively, please contact the conference host, journal, or publisher (according to the circumstance) for further details regarding this item. If a citation is listed in this record, the item has been published and is available via open-access avenues or a journal/database subscription. Contact your library for assistance in obtaining the as-published article.-
All Items in this repository are protected by copyright, with all rights reserved, unless otherwise indicated.