Patients Undergoing Radiation Treatment Were Clinically Evaluated For Skin Integrity, Pain, and Itching in a Preliminary Trial Using Radiaplexrx Gel Containing 0.2 Hyaluronic Acid

2.50
Hdl Handle:
http://hdl.handle.net/10755/165352
Category:
Abstract
Type:
Presentation
Title:
Patients Undergoing Radiation Treatment Were Clinically Evaluated For Skin Integrity, Pain, and Itching in a Preliminary Trial Using Radiaplexrx Gel Containing 0.2 Hyaluronic Acid
Author(s):
Moore, K.; Haas, M.; Purdy, K.
Author Details:
K. Moore, Dept. of Veteran Affairs, Radiation Oncology Service, East Orange, New Jersey, USA; M. Haas; K. Purdy
Abstract:
Acute radiation dermatitis is a side effect of radiotherapy. It has been estimated that approximately 95% of radiation therapy patients treated for cancer will experience a skin reaction and 87% of women receiving radiation treatment for breast cancer will develop radiation dermatitis (Prorock et al., 1999; Fisher et al., 2002). Peer-reviewed clinical trials are sparse and inconsistent on efficacy of topical treatments for radiation dermatitis, leaving the patient and practitioner without a solution as to an effective treatment (Wickline, 2004). Purpose: Studies have suggested that hyaluronic acid and mannan polysaccharides reduce acute radiation-induced dermatitis. RadiaPlexRx™, a topical gel composed of these ingredients, was clinically evaluated for efficacy in radiation dermatitis. Theoretical/Scientific Framework: Hyaluronic acid, 0.2%, was shown clinically to significantly improve radiation dermatitis as compared to placebo cream (Liguori et al., 1997). Hyaluronic acid may support skin because it is a natural component of the extracellular matrix of the dermis. Methods: A pilot study was conducted on 20 patients who were receiving radiation treatment for breast cancer, chest wall after a mastectomy, thorax and abdomen, forehead and rectum. 60% of patients received radiation dosages of 6040cGy or higher. Patients were instructed to apply gel three times daily. Data Analysis: Nurses assessed patient dermatitis using the NCI Common Toxicity Criteria. Patients reported their evaluations using a Patient Survey Questionnaire. Data was entered into SPSS and descriptive statistics calculated. Findings and Implications: Results showed 90% of patients clinically evaluated experienced no dry desquamation or severe erythema. 85% of patients experienced no itching and 70% of patients experienced no painful skin problems. 75% experienced increased moisturizing effects. 100% of patients stated they would recommend it to others undergoing the same treatment. Further studies are warranted as the gel seemed to be well tolerated, non-irritating and may help prevent dry desquamation. RT nurses need to feel comfortable recommending a well-tolerated and effective treatment for their patients during the radiation treatment phase and for home care. This gel offered a potential solution for treating mild to medium dermatitis associated with most radiation protocols, bearing in mind that each case required individual assessment.
Repository Posting Date:
27-Oct-2011
Date of Publication:
27-Oct-2011
Conference Date:
2005
Conference Name:
30th Annual Oncology Nursing Society Congress
Conference Host:
Oncology Nursing Society
Conference Location:
Orlando, Florida, USA
Sponsors:
Funding Sources: MPM Medical provided products for pilot study.
Note:
This is an abstract-only submission. If the author has submitted a full-text item based on this abstract, you may find it by browsing the Virginia Henderson Global Nursing e-Repository by author. If author contact information is available in this abstract, please feel free to contact him or her with your queries regarding this submission. Alternatively, please contact the conference host, journal, or publisher (according to the circumstance) for further details regarding this item. If a citation is listed in this record, the item has been published and is available via open-access avenues or a journal/database subscription. Contact your library for assistance in obtaining the as-published article.

Full metadata record

DC FieldValue Language
dc.type.categoryAbstracten_US
dc.typePresentationen_GB
dc.titlePatients Undergoing Radiation Treatment Were Clinically Evaluated For Skin Integrity, Pain, and Itching in a Preliminary Trial Using Radiaplexrx Gel Containing 0.2 Hyaluronic Aciden_GB
dc.contributor.authorMoore, K.en_US
dc.contributor.authorHaas, M.en_US
dc.contributor.authorPurdy, K.en_US
dc.author.detailsK. Moore, Dept. of Veteran Affairs, Radiation Oncology Service, East Orange, New Jersey, USA; M. Haas; K. Purdyen_US
dc.identifier.urihttp://hdl.handle.net/10755/165352-
dc.description.abstractAcute radiation dermatitis is a side effect of radiotherapy. It has been estimated that approximately 95% of radiation therapy patients treated for cancer will experience a skin reaction and 87% of women receiving radiation treatment for breast cancer will develop radiation dermatitis (Prorock et al., 1999; Fisher et al., 2002). Peer-reviewed clinical trials are sparse and inconsistent on efficacy of topical treatments for radiation dermatitis, leaving the patient and practitioner without a solution as to an effective treatment (Wickline, 2004). Purpose: Studies have suggested that hyaluronic acid and mannan polysaccharides reduce acute radiation-induced dermatitis. RadiaPlexRx™, a topical gel composed of these ingredients, was clinically evaluated for efficacy in radiation dermatitis. Theoretical/Scientific Framework: Hyaluronic acid, 0.2%, was shown clinically to significantly improve radiation dermatitis as compared to placebo cream (Liguori et al., 1997). Hyaluronic acid may support skin because it is a natural component of the extracellular matrix of the dermis. Methods: A pilot study was conducted on 20 patients who were receiving radiation treatment for breast cancer, chest wall after a mastectomy, thorax and abdomen, forehead and rectum. 60% of patients received radiation dosages of 6040cGy or higher. Patients were instructed to apply gel three times daily. Data Analysis: Nurses assessed patient dermatitis using the NCI Common Toxicity Criteria. Patients reported their evaluations using a Patient Survey Questionnaire. Data was entered into SPSS and descriptive statistics calculated. Findings and Implications: Results showed 90% of patients clinically evaluated experienced no dry desquamation or severe erythema. 85% of patients experienced no itching and 70% of patients experienced no painful skin problems. 75% experienced increased moisturizing effects. 100% of patients stated they would recommend it to others undergoing the same treatment. Further studies are warranted as the gel seemed to be well tolerated, non-irritating and may help prevent dry desquamation. RT nurses need to feel comfortable recommending a well-tolerated and effective treatment for their patients during the radiation treatment phase and for home care. This gel offered a potential solution for treating mild to medium dermatitis associated with most radiation protocols, bearing in mind that each case required individual assessment.en_GB
dc.date.available2011-10-27T12:17:00Z-
dc.date.issued2011-10-27en_GB
dc.date.accessioned2011-10-27T12:17:00Z-
dc.conference.date2005en_US
dc.conference.name30th Annual Oncology Nursing Society Congressen_US
dc.conference.hostOncology Nursing Societyen_US
dc.conference.locationOrlando, Florida, USAen_US
dc.description.sponsorshipFunding Sources: MPM Medical provided products for pilot study.-
dc.description.noteThis is an abstract-only submission. If the author has submitted a full-text item based on this abstract, you may find it by browsing the Virginia Henderson Global Nursing e-Repository by author. If author contact information is available in this abstract, please feel free to contact him or her with your queries regarding this submission. Alternatively, please contact the conference host, journal, or publisher (according to the circumstance) for further details regarding this item. If a citation is listed in this record, the item has been published and is available via open-access avenues or a journal/database subscription. Contact your library for assistance in obtaining the as-published article.-
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