Fatigue, Depression, and Biomarkers in Women With Breast Cancer: A Pilot Study

2.50
Hdl Handle:
http://hdl.handle.net/10755/165391
Category:
Abstract
Type:
Presentation
Title:
Fatigue, Depression, and Biomarkers in Women With Breast Cancer: A Pilot Study
Author(s):
Piper, Barbara; Payne, J.; Rabinowitz, I.; Zimmerman, M. D.
Author Details:
Barbara Piper, University of Nebraska Medical Center, College of Nursing Adult Health & Fitness, Omaha, Nebraska, USA, email: barbarapiper@msn.com; J. Payne; I. Rabinowitz; M. D. Zimmerman
Abstract:
Because fatigue and depression frequently correlate with one another, a common biologic pathway has been proposed for these states. This is the first study to examine how specific biologic markers serotonin and bilirubin are related to these states. This is a significant area for research as findings can contribute to an improved understanding of underlying mechanisms, risk factors, and treatments. Components of the Integrated Fatigue Model guided this correlational, repeated measures study at a large Southwestern University Cancer Center. Data were collected using the standardized Piper Fatigue Scale (PFS), the Center for Epidemiologic Depression Survey (CES-D), a demographic form, and medical record data. Newly diagnosed breast cancer patients [N=11, stages I or II and age and menopausally-matched healthy controls [N=11], completed instruments during chemotherapy (CT) cycles 1 & 4, on Day 1 before CT, and two weeks later at nadirs (T1-T4). All women were admitted Days 1-3, cycles 1 & 4. Bilirubins and CBCs were drawn Day 1; serotonins Days 2 & 3. Descriptive and inferential statistics were used in data analysis. Subjects were Caucasian (54.5%) and Hispanic (36.5%), high school educated with a mean age of 47.5 years. Patients had significantly higher mean fatigue (PFS) (p< .0001) and depression scores (CES-D) (p=.006) and bilirubin and serotonin were significantly reduced (p<.05). Serotonin (p=.03) and bilirubin (p=.007) significantly correlated with fatigue, and serotonin significantly correlated with depression (p=.004). These differences in patients and their associated biomarkers warrants further study and underscores the need to screen for these states in practice.
Repository Posting Date:
27-Oct-2011
Date of Publication:
27-Oct-2011
Conference Date:
2003
Conference Name:
28th Annual Oncology Nursing Society Congress
Conference Host:
Oncology Nursing Society
Conference Location:
Denver, Colorado, USA
Note:
This is an abstract-only submission. If the author has submitted a full-text item based on this abstract, you may find it by browsing the Virginia Henderson Global Nursing e-Repository by author. If author contact information is available in this abstract, please feel free to contact him or her with your queries regarding this submission. Alternatively, please contact the conference host, journal, or publisher (according to the circumstance) for further details regarding this item. If a citation is listed in this record, the item has been published and is available via open-access avenues or a journal/database subscription. Contact your library for assistance in obtaining the as-published article.

Full metadata record

DC FieldValue Language
dc.type.categoryAbstracten_US
dc.typePresentationen_GB
dc.titleFatigue, Depression, and Biomarkers in Women With Breast Cancer: A Pilot Studyen_GB
dc.contributor.authorPiper, Barbaraen_US
dc.contributor.authorPayne, J.en_US
dc.contributor.authorRabinowitz, I.en_US
dc.contributor.authorZimmerman, M. D.en_US
dc.author.detailsBarbara Piper, University of Nebraska Medical Center, College of Nursing Adult Health & Fitness, Omaha, Nebraska, USA, email: barbarapiper@msn.com; J. Payne; I. Rabinowitz; M. D. Zimmermanen_US
dc.identifier.urihttp://hdl.handle.net/10755/165391-
dc.description.abstractBecause fatigue and depression frequently correlate with one another, a common biologic pathway has been proposed for these states. This is the first study to examine how specific biologic markers serotonin and bilirubin are related to these states. This is a significant area for research as findings can contribute to an improved understanding of underlying mechanisms, risk factors, and treatments. Components of the Integrated Fatigue Model guided this correlational, repeated measures study at a large Southwestern University Cancer Center. Data were collected using the standardized Piper Fatigue Scale (PFS), the Center for Epidemiologic Depression Survey (CES-D), a demographic form, and medical record data. Newly diagnosed breast cancer patients [N=11, stages I or II and age and menopausally-matched healthy controls [N=11], completed instruments during chemotherapy (CT) cycles 1 &amp; 4, on Day 1 before CT, and two weeks later at nadirs (T1-T4). All women were admitted Days 1-3, cycles 1 &amp; 4. Bilirubins and CBCs were drawn Day 1; serotonins Days 2 &amp; 3. Descriptive and inferential statistics were used in data analysis. Subjects were Caucasian (54.5%) and Hispanic (36.5%), high school educated with a mean age of 47.5 years. Patients had significantly higher mean fatigue (PFS) (p&lt; .0001) and depression scores (CES-D) (p=.006) and bilirubin and serotonin were significantly reduced (p&lt;.05). Serotonin (p=.03) and bilirubin (p=.007) significantly correlated with fatigue, and serotonin significantly correlated with depression (p=.004). These differences in patients and their associated biomarkers warrants further study and underscores the need to screen for these states in practice.en_GB
dc.date.available2011-10-27T12:17:42Z-
dc.date.issued2011-10-27en_GB
dc.date.accessioned2011-10-27T12:17:42Z-
dc.conference.date2003en_US
dc.conference.name28th Annual Oncology Nursing Society Congressen_US
dc.conference.hostOncology Nursing Societyen_US
dc.conference.locationDenver, Colorado, USAen_US
dc.description.noteThis is an abstract-only submission. If the author has submitted a full-text item based on this abstract, you may find it by browsing the Virginia Henderson Global Nursing e-Repository by author. If author contact information is available in this abstract, please feel free to contact him or her with your queries regarding this submission. Alternatively, please contact the conference host, journal, or publisher (according to the circumstance) for further details regarding this item. If a citation is listed in this record, the item has been published and is available via open-access avenues or a journal/database subscription. Contact your library for assistance in obtaining the as-published article.-
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