2.50
Hdl Handle:
http://hdl.handle.net/10755/165602
Category:
Abstract
Type:
Presentation
Title:
Physiological Biomarkers of Cancer Treatment-Related Fatigue
Author(s):
Payne, Judith
Author Details:
Judith Payne, Assistant Professor, Wayne State University, College of Nursing, Detroit, Michigan, USA, email: jkpayne@wayne.edu
Abstract:
Fatigue is the most frequently reported symptom of cancer and cancer therapy. Despite this fact, there is relatively minimal information regarding its intensity, exacerbating factors, and its underlying mechanisms. The purposes of this study were to evaluate changes over time in serum melatonin, serotonin, cortisol, hemoglobin, and bilirubin levels in patients with early stage breast cancer receiving chemotherapy; explore correlations between these posited fatigue biomarkers and subjective fatigue; and determine how changes may be related to insomnia, depression, and health-related quality of life. Using a conceptual framework viewing fatigue as a multi-dimensional experience, this study used a prospective descriptive repeated measures design. A sample of 20 subjects (n = 10 and n = 10 matched healthy controls) diagnosed with early stage breast cancer and receiving chemotherapy for the first time were recruited from a large academic southwestern medical center. Instruments included a demographic questionnaire, medical record reviews and self-reported medical history, the Piper Fatigue Scale, Fatigue Intensity Scale, Morin Sleep Diary, CES-D, SF36, and sleep wrist actigraphs. Physiological serum measures were drawn pre and post treatment at baseline and three months. Following completion of data collection, final data analysis will include descriptive statistics and repeated measures ANOVA. Preliminary data indicate that subjects experienced fatigue as a common and distressing side effect of chemotherapy treatment, with changes detected in physiological serum markers as well as sleep patterns. Understanding mechanisms of fatigue and the nature of relationships between physiological fatigue biomarkers and subjective fatigue will enable fatigue research-based interventions to be tested in future studies.
Repository Posting Date:
27-Oct-2011
Date of Publication:
27-Oct-2011
Conference Date:
2002
Conference Name:
27th Annual Oncology Nursing Society Congress
Conference Host:
Oncology Nursing Society
Conference Location:
Washington, D.C., USA
Note:
This is an abstract-only submission. If the author has submitted a full-text item based on this abstract, you may find it by browsing the Virginia Henderson Global Nursing e-Repository by author. If author contact information is available in this abstract, please feel free to contact him or her with your queries regarding this submission. Alternatively, please contact the conference host, journal, or publisher (according to the circumstance) for further details regarding this item. If a citation is listed in this record, the item has been published and is available via open-access avenues or a journal/database subscription. Contact your library for assistance in obtaining the as-published article.

Full metadata record

DC FieldValue Language
dc.type.categoryAbstracten_US
dc.typePresentationen_GB
dc.titlePhysiological Biomarkers of Cancer Treatment-Related Fatigueen_GB
dc.contributor.authorPayne, Judithen_US
dc.author.detailsJudith Payne, Assistant Professor, Wayne State University, College of Nursing, Detroit, Michigan, USA, email: jkpayne@wayne.eduen_US
dc.identifier.urihttp://hdl.handle.net/10755/165602-
dc.description.abstractFatigue is the most frequently reported symptom of cancer and cancer therapy. Despite this fact, there is relatively minimal information regarding its intensity, exacerbating factors, and its underlying mechanisms. The purposes of this study were to evaluate changes over time in serum melatonin, serotonin, cortisol, hemoglobin, and bilirubin levels in patients with early stage breast cancer receiving chemotherapy; explore correlations between these posited fatigue biomarkers and subjective fatigue; and determine how changes may be related to insomnia, depression, and health-related quality of life. Using a conceptual framework viewing fatigue as a multi-dimensional experience, this study used a prospective descriptive repeated measures design. A sample of 20 subjects (n = 10 and n = 10 matched healthy controls) diagnosed with early stage breast cancer and receiving chemotherapy for the first time were recruited from a large academic southwestern medical center. Instruments included a demographic questionnaire, medical record reviews and self-reported medical history, the Piper Fatigue Scale, Fatigue Intensity Scale, Morin Sleep Diary, CES-D, SF36, and sleep wrist actigraphs. Physiological serum measures were drawn pre and post treatment at baseline and three months. Following completion of data collection, final data analysis will include descriptive statistics and repeated measures ANOVA. Preliminary data indicate that subjects experienced fatigue as a common and distressing side effect of chemotherapy treatment, with changes detected in physiological serum markers as well as sleep patterns. Understanding mechanisms of fatigue and the nature of relationships between physiological fatigue biomarkers and subjective fatigue will enable fatigue research-based interventions to be tested in future studies.en_GB
dc.date.available2011-10-27T12:21:39Z-
dc.date.issued2011-10-27en_GB
dc.date.accessioned2011-10-27T12:21:39Z-
dc.conference.date2002en_US
dc.conference.name27th Annual Oncology Nursing Society Congressen_US
dc.conference.hostOncology Nursing Societyen_US
dc.conference.locationWashington, D.C., USAen_US
dc.description.noteThis is an abstract-only submission. If the author has submitted a full-text item based on this abstract, you may find it by browsing the Virginia Henderson Global Nursing e-Repository by author. If author contact information is available in this abstract, please feel free to contact him or her with your queries regarding this submission. Alternatively, please contact the conference host, journal, or publisher (according to the circumstance) for further details regarding this item. If a citation is listed in this record, the item has been published and is available via open-access avenues or a journal/database subscription. Contact your library for assistance in obtaining the as-published article.-
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