2.50
Hdl Handle:
http://hdl.handle.net/10755/165603
Category:
Abstract
Type:
Presentation
Title:
Characterization of Biotherapy-Induced Peripheral Neuropathy
Author(s):
Visovsky, Constance
Author Details:
Constance Visovsky, Case Western Reserve University, Frances Payne Bolton School of Nursing, Cleveland, Ohio, USA, email: cxv6@po.cwru.edu
Abstract:
Problem/Purpose: Patients treated with neurotoxic drugs experience peripheral neuropathy resulting in alterations in hearing, vision, touch, balance, and blood pressure. This study is unique in its prospective design, correlating physical change with clinical and physiologic measures. Limited data exist quantifying physiologic peripheral nerve changes in individuals receiving biotherapy. Studies of factors predictive of susceptibility to neuropathy are lacking. This exploratory, predictive study will characterize peripheral nerve function over time in individuals undergoing biotherapy. The aims are to determine: 1) changes in peripheral nerve function following treatment with biotherapy, 2) the extent to which individual characteristics predict peripheral nerve changes beyond the effect of drugs, and 3) the relationship between extent of neuropathy and symptom distress. Criterion validity of clinical measures assessing effects of neuropathy will be determined. Framework: A physiologic framework of neuronal degeneration is used. Methods: Independent variable: Cumulative dose of biotherapy over time. Moderating variables: Age and gender. Outcome variables: Sensation, gait/balance, vibration, muscle strength, vision, hearing, orthostatic blood pressure, and symptom distress. A convenience sample of 65 subjects are being recruited from patients diagnosed with cancer receiving biologic agents at three cancer centers in Cleveland, Ohio. The sample size was determined by power analysis (alpha .05 power .87, effect size .25). Measures are taken at baseline, one, and three months after treatment, and two months post-treatment. Data Analysis: Data will be analyzed using plots and regression slopes to determine change over time. Hierarchical regression will determine predictors (age, gender) controlling for cumulative drug dose. Multiple regression will examine the relationship between peripheral nerve changes and symptom distress. Pearson's correlation coefficients will determine criterion validity of clinical measures for hearing and muscle strength. Implications: The characterization of peripheral nerve changes would assist oncology nurses to identify clients at risk of severe peripheral nerve injury and in developing educational materials to prepare clients and their families for life-style adjustments. Demonstrating if clinical measures are sufficient in monitoring peripheral neuropathy may result in clinical practice changes. Lastly, study findings are essential to the development of interventions to preserve functional status and decrease symptom distress in clients receiving neurotoxic agents.
Repository Posting Date:
27-Oct-2011
Date of Publication:
27-Oct-2011
Conference Date:
2002
Conference Name:
27th Annual Oncology Nursing Society Congress
Conference Host:
Oncology Nursing Society
Conference Location:
Washington, D.C., USA
Note:
This is an abstract-only submission. If the author has submitted a full-text item based on this abstract, you may find it by browsing the Virginia Henderson Global Nursing e-Repository by author. If author contact information is available in this abstract, please feel free to contact him or her with your queries regarding this submission. Alternatively, please contact the conference host, journal, or publisher (according to the circumstance) for further details regarding this item. If a citation is listed in this record, the item has been published and is available via open-access avenues or a journal/database subscription. Contact your library for assistance in obtaining the as-published article.

Full metadata record

DC FieldValue Language
dc.type.categoryAbstracten_US
dc.typePresentationen_GB
dc.titleCharacterization of Biotherapy-Induced Peripheral Neuropathyen_GB
dc.contributor.authorVisovsky, Constanceen_US
dc.author.detailsConstance Visovsky, Case Western Reserve University, Frances Payne Bolton School of Nursing, Cleveland, Ohio, USA, email: cxv6@po.cwru.eduen_US
dc.identifier.urihttp://hdl.handle.net/10755/165603-
dc.description.abstractProblem/Purpose: Patients treated with neurotoxic drugs experience peripheral neuropathy resulting in alterations in hearing, vision, touch, balance, and blood pressure. This study is unique in its prospective design, correlating physical change with clinical and physiologic measures. Limited data exist quantifying physiologic peripheral nerve changes in individuals receiving biotherapy. Studies of factors predictive of susceptibility to neuropathy are lacking. This exploratory, predictive study will characterize peripheral nerve function over time in individuals undergoing biotherapy. The aims are to determine: 1) changes in peripheral nerve function following treatment with biotherapy, 2) the extent to which individual characteristics predict peripheral nerve changes beyond the effect of drugs, and 3) the relationship between extent of neuropathy and symptom distress. Criterion validity of clinical measures assessing effects of neuropathy will be determined. Framework: A physiologic framework of neuronal degeneration is used. Methods: Independent variable: Cumulative dose of biotherapy over time. Moderating variables: Age and gender. Outcome variables: Sensation, gait/balance, vibration, muscle strength, vision, hearing, orthostatic blood pressure, and symptom distress. A convenience sample of 65 subjects are being recruited from patients diagnosed with cancer receiving biologic agents at three cancer centers in Cleveland, Ohio. The sample size was determined by power analysis (alpha .05 power .87, effect size .25). Measures are taken at baseline, one, and three months after treatment, and two months post-treatment. Data Analysis: Data will be analyzed using plots and regression slopes to determine change over time. Hierarchical regression will determine predictors (age, gender) controlling for cumulative drug dose. Multiple regression will examine the relationship between peripheral nerve changes and symptom distress. Pearson's correlation coefficients will determine criterion validity of clinical measures for hearing and muscle strength. Implications: The characterization of peripheral nerve changes would assist oncology nurses to identify clients at risk of severe peripheral nerve injury and in developing educational materials to prepare clients and their families for life-style adjustments. Demonstrating if clinical measures are sufficient in monitoring peripheral neuropathy may result in clinical practice changes. Lastly, study findings are essential to the development of interventions to preserve functional status and decrease symptom distress in clients receiving neurotoxic agents.en_GB
dc.date.available2011-10-27T12:21:40Z-
dc.date.issued2011-10-27en_GB
dc.date.accessioned2011-10-27T12:21:40Z-
dc.conference.date2002en_US
dc.conference.name27th Annual Oncology Nursing Society Congressen_US
dc.conference.hostOncology Nursing Societyen_US
dc.conference.locationWashington, D.C., USAen_US
dc.description.noteThis is an abstract-only submission. If the author has submitted a full-text item based on this abstract, you may find it by browsing the Virginia Henderson Global Nursing e-Repository by author. If author contact information is available in this abstract, please feel free to contact him or her with your queries regarding this submission. Alternatively, please contact the conference host, journal, or publisher (according to the circumstance) for further details regarding this item. If a citation is listed in this record, the item has been published and is available via open-access avenues or a journal/database subscription. Contact your library for assistance in obtaining the as-published article.-
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