2.50
Hdl Handle:
http://hdl.handle.net/10755/165692
Category:
Abstract
Type:
Presentation
Title:
Individual Differences in Severity of Oral Mucositis
Author(s):
Peterson, D.
Author Details:
D. Peterson, Department of Oral Diagnosis, School of Dental Medicine, Farmington, Connecticut, USA
Abstract:
Problem and Significance: Tissue injury associated with the oral mucositis that is caused by high does chemotherapy is not only a distressing side effect, but a dose-limiting one as well because of severe pain, bleeding and infection. the typical pattern of oral tissue injury follows an inverted U shaped curve with an increase in severity of erythema and ulceration during the first week following completion of chemotherapy and a decline in the second week. Less is known about individual patterns of tissue injury, but anecdotal clinical evidence and plots of individual data over time indicate considerable variability in trajectories of injury and repair. Thus, to better understand the nature of tissue injury in oral mucositis, it is important to study individual trajectories. Purpose: The primary purpose of this presentation is to report the results of individual growth curve analysis applied to repeated measures data from the Oral Mucositis Index, which measures injury to oral mucosal tissue. Scientific Framework: The progression of injury to oral mucosal tissue that commonly results from high dose chemotherapy or radiation is a complex phenomenon which is multi-factorial in nature. Important etiologic factors include toxicity levels of anti-neoplastic drugs used, levels of radiation, and predisposing patient factors such as medical history and life style variables (e.g., tobacco, alcohol). Methods: This study was a secondary analysis of data from 153 cancer patients receiving high does chemotherapy and enrolled in a clinical trial of an intervention for oral pain and mucositis. Instruments included a Patient Data Form (administered at baseline), and the 20 item Oral Mucositis Index and Brief Pain Inventory, which were administered by trained data collectors at baseline, then every third day following completion of chemotherapy until 21 days or discharge. Data Analysis: Individual growth curves in oral mucositis were analyzed by SAS Proc MIXED. A cubic polynomial model for change over time was estimated and then individual deviations from this model were estimated. These deviations were then subjected to a hierarchical cluster analysis to identify groups of patients who showed similar patterns of change in tissue injury over time. These groups were examined for differences in individual and clinical characteristics. Finally, deviations from the model were correlated with other concomitant variables to improve our understanding of relationships among tissue injury, acute oral pain, and selected patient characteristics. Findings and Implications: Individual growth curve analysis indicated that two distinct patterns of change in ulceration and erythema could be identified. One group showed a small rise in tissue damage over the first week after completion of chemotherapy and a rapid resolution of injury to baseline levels. The second (and larger) group showed a more radical rise in tissue injury over the first week with no signs of recovery within the analysis timeframe. The presentation will discuss how these groups differ and examine how other concomitant variables correlate with the growth curve parameters.
Repository Posting Date:
27-Oct-2011
Date of Publication:
27-Oct-2011
Conference Date:
2001
Conference Name:
26th Annual Oncology Nursing Society Congress
Conference Host:
Oncology Nursing Society
Conference Location:
San Diego, California, USA
Note:
This is an abstract-only submission. If the author has submitted a full-text item based on this abstract, you may find it by browsing the Virginia Henderson Global Nursing e-Repository by author. If author contact information is available in this abstract, please feel free to contact him or her with your queries regarding this submission. Alternatively, please contact the conference host, journal, or publisher (according to the circumstance) for further details regarding this item. If a citation is listed in this record, the item has been published and is available via open-access avenues or a journal/database subscription. Contact your library for assistance in obtaining the as-published article.

Full metadata record

DC FieldValue Language
dc.type.categoryAbstracten_US
dc.typePresentationen_GB
dc.titleIndividual Differences in Severity of Oral Mucositisen_GB
dc.contributor.authorPeterson, D.en_US
dc.author.detailsD. Peterson, Department of Oral Diagnosis, School of Dental Medicine, Farmington, Connecticut, USAen_US
dc.identifier.urihttp://hdl.handle.net/10755/165692-
dc.description.abstractProblem and Significance: Tissue injury associated with the oral mucositis that is caused by high does chemotherapy is not only a distressing side effect, but a dose-limiting one as well because of severe pain, bleeding and infection. the typical pattern of oral tissue injury follows an inverted U shaped curve with an increase in severity of erythema and ulceration during the first week following completion of chemotherapy and a decline in the second week. Less is known about individual patterns of tissue injury, but anecdotal clinical evidence and plots of individual data over time indicate considerable variability in trajectories of injury and repair. Thus, to better understand the nature of tissue injury in oral mucositis, it is important to study individual trajectories. Purpose: The primary purpose of this presentation is to report the results of individual growth curve analysis applied to repeated measures data from the Oral Mucositis Index, which measures injury to oral mucosal tissue. Scientific Framework: The progression of injury to oral mucosal tissue that commonly results from high dose chemotherapy or radiation is a complex phenomenon which is multi-factorial in nature. Important etiologic factors include toxicity levels of anti-neoplastic drugs used, levels of radiation, and predisposing patient factors such as medical history and life style variables (e.g., tobacco, alcohol). Methods: This study was a secondary analysis of data from 153 cancer patients receiving high does chemotherapy and enrolled in a clinical trial of an intervention for oral pain and mucositis. Instruments included a Patient Data Form (administered at baseline), and the 20 item Oral Mucositis Index and Brief Pain Inventory, which were administered by trained data collectors at baseline, then every third day following completion of chemotherapy until 21 days or discharge. Data Analysis: Individual growth curves in oral mucositis were analyzed by SAS Proc MIXED. A cubic polynomial model for change over time was estimated and then individual deviations from this model were estimated. These deviations were then subjected to a hierarchical cluster analysis to identify groups of patients who showed similar patterns of change in tissue injury over time. These groups were examined for differences in individual and clinical characteristics. Finally, deviations from the model were correlated with other concomitant variables to improve our understanding of relationships among tissue injury, acute oral pain, and selected patient characteristics. Findings and Implications: Individual growth curve analysis indicated that two distinct patterns of change in ulceration and erythema could be identified. One group showed a small rise in tissue damage over the first week after completion of chemotherapy and a rapid resolution of injury to baseline levels. The second (and larger) group showed a more radical rise in tissue injury over the first week with no signs of recovery within the analysis timeframe. The presentation will discuss how these groups differ and examine how other concomitant variables correlate with the growth curve parameters.en_GB
dc.date.available2011-10-27T12:23:14Z-
dc.date.issued2011-10-27en_GB
dc.date.accessioned2011-10-27T12:23:14Z-
dc.conference.date2001en_US
dc.conference.name26th Annual Oncology Nursing Society Congressen_US
dc.conference.hostOncology Nursing Societyen_US
dc.conference.locationSan Diego, California, USAen_US
dc.description.noteThis is an abstract-only submission. If the author has submitted a full-text item based on this abstract, you may find it by browsing the Virginia Henderson Global Nursing e-Repository by author. If author contact information is available in this abstract, please feel free to contact him or her with your queries regarding this submission. Alternatively, please contact the conference host, journal, or publisher (according to the circumstance) for further details regarding this item. If a citation is listed in this record, the item has been published and is available via open-access avenues or a journal/database subscription. Contact your library for assistance in obtaining the as-published article.-
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