2.50
Hdl Handle:
http://hdl.handle.net/10755/211591
Type:
Research Study
Title:
QUALITY OF LIFE MEASURES IN DEPRESSED ACUTE CORONARY SYNDROME PATIENTS
Abstract:
Purpose/Aims:  To compare Health Related Quality of Life (HRQL) in hospitalized ACS patients with and without depression using a novel scoring method correlating the physical component score (PCS) and mental component score (MCS) of the Short Form 12 (SF-12). Background:  HRQL is known to be poorer in both depressed patients and in acute coronary syndrome (ACS) patients.  However, to date no investigators have studied the effect of clinical depression on HRQL in hospitalized ACS patients. Methods: One hundred ACS patients were enrolled (63.5 ± 12.2 years, 31% female) at an urban cardiac unit.  Diagnostic interviews using the Diagnostic Interview and Structured Hamilton (DISH) were conducted by advanced practice nurses to establish the diagnosis of depression.  All study participants completed the SF-12 prior to the interview.  We used correlated scoring of the SF-12 following the methods of Farivar et al who derived coefficients from an obliquely rotated factor solution in a sample of 7093 community dwelling individuals seeking medical care. This method accounts for inconsistencies between item scores and PCS/MCS summary scores and addresses crossover symptoms between items used to measure mental health symptoms and those used to measure physical health symptoms. MCS and PCS scores were standardized to a mean of 50 ± 10; lower scores indicate lower HRQL. Depressed vs. non depressed patients were compared by Student t-tests. Sample characteristics were compared using t-test for continuous variables and Chi-Square for categorical variables. Significance was set at p = .01 to account for multiple testing. Results: Depressed ACS patients (n = 23), were more often single (74% vs 36%, p. = .001), female (52% vs 25%, p. = .012), younger (56.6 ± 13.4 vs 65.5 ±  11.2 years, p. = .002), and had a greater BMI (32.1 ± 7.3 vs 29.4  ± 4.5, p. = .002) compared to non-depressed ACS patients. Both correlated PCS scores (32.8 ±7.5 vs. 49.6 ± 7.6, p = .000) and correlated MCS scores (31.0 ± 10.9 vs. 43.5, ±  10.0, p = .000) were significantly lower in depressed ACS patients compared to non-depressed peers. Depressed and non-depressed ACS patients compared unfavorably to reference groups of depressed only and cardiac disease individuals (Table). Implications: Compared to non-depressed ACS patients, depressed ACS patients exhibit lower HRQL in both mental and physical domains. In the presence of an ACS, both negative mental health symptoms and physical symptoms are increased in individuals with depression. The findings indicate that physical symptoms cannot be attributed to the ACS alone, but are also influenced by depression. Further study is needed to explicate the relationship between mental and physical domains in depressed ACS patients.
Keywords:
Acute Coronary Syndrome; Hospitalized patients; Depression
Repository Posting Date:
20-Feb-2012
Date of Publication:
20-Feb-2012
Other Identifiers:
5549
Sponsors:
Western Institute of Nursing

Full metadata record

DC FieldValue Language
dc.typeResearch Studyen_GB
dc.titleQUALITY OF LIFE MEASURES IN DEPRESSED ACUTE CORONARY SYNDROME PATIENTSen_GB
dc.identifier.urihttp://hdl.handle.net/10755/211591-
dc.description.abstractPurpose/Aims:  To compare Health Related Quality of Life (HRQL) in hospitalized ACS patients with and without depression using a novel scoring method correlating the physical component score (PCS) and mental component score (MCS) of the Short Form 12 (SF-12). Background:  HRQL is known to be poorer in both depressed patients and in acute coronary syndrome (ACS) patients.  However, to date no investigators have studied the effect of clinical depression on HRQL in hospitalized ACS patients. Methods: One hundred ACS patients were enrolled (63.5 ± 12.2 years, 31% female) at an urban cardiac unit.  Diagnostic interviews using the Diagnostic Interview and Structured Hamilton (DISH) were conducted by advanced practice nurses to establish the diagnosis of depression.  All study participants completed the SF-12 prior to the interview.  We used correlated scoring of the SF-12 following the methods of Farivar et al who derived coefficients from an obliquely rotated factor solution in a sample of 7093 community dwelling individuals seeking medical care. This method accounts for inconsistencies between item scores and PCS/MCS summary scores and addresses crossover symptoms between items used to measure mental health symptoms and those used to measure physical health symptoms. MCS and PCS scores were standardized to a mean of 50 ± 10; lower scores indicate lower HRQL. Depressed vs. non depressed patients were compared by Student t-tests. Sample characteristics were compared using t-test for continuous variables and Chi-Square for categorical variables. Significance was set at p = .01 to account for multiple testing. Results: Depressed ACS patients (n = 23), were more often single (74% vs 36%, p. = .001), female (52% vs 25%, p. = .012), younger (56.6 ± 13.4 vs 65.5 ±  11.2 years, p. = .002), and had a greater BMI (32.1 ± 7.3 vs 29.4  ± 4.5, p. = .002) compared to non-depressed ACS patients. Both correlated PCS scores (32.8 ±7.5 vs. 49.6 ± 7.6, p = .000) and correlated MCS scores (31.0 ± 10.9 vs. 43.5, ±  10.0, p = .000) were significantly lower in depressed ACS patients compared to non-depressed peers. Depressed and non-depressed ACS patients compared unfavorably to reference groups of depressed only and cardiac disease individuals (Table). Implications: Compared to non-depressed ACS patients, depressed ACS patients exhibit lower HRQL in both mental and physical domains. In the presence of an ACS, both negative mental health symptoms and physical symptoms are increased in individuals with depression. The findings indicate that physical symptoms cannot be attributed to the ACS alone, but are also influenced by depression. Further study is needed to explicate the relationship between mental and physical domains in depressed ACS patients.en_GB
dc.subjectAcute Coronary Syndromeen_GB
dc.subjectHospitalized patientsen_GB
dc.subjectDepressionen_GB
dc.date.available2012-02-20T12:04:05Z-
dc.date.issued2012-02-20T12:04:05Z-
dc.date.accessioned2012-02-20T12:04:05Z-
dc.description.sponsorshipWestern Institute of Nursingen_GB
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