2.50
Hdl Handle:
http://hdl.handle.net/10755/211663
Type:
Research Study
Title:
ABDOMINAL DISCOMFORT AFTER INGESTING INTESTINAL PERMEABILITY TEST SOLUTION
Abstract:
Background: Chronic abdominal pain is a common symptom reported in the United States. The Gastrointestinal Pain Pointer (GIPP) is a computerized tool designed to improve both subjective and objective data capture of abdominal discomfort in real-time. Aim: The purpose of this study was to profile patients who reported having abdominal discomfort on the GIPP within the first hour of drinking an intestinal permeability test solution. Methods: Individuals with chronic abdominal pain and healthy volunteers ages 13-45, overweight and healthy weight according to BMI, were recruited to a natural history protocol. After an overnight fast, blood was collected and individuals were asked to drink a 100 ml intestinal permeability test solution composed of lactulose, mannitol, sucralose, and sucrose. Individuals were then monitored for the next 5 hours during which all urine was collected and the GIPP was administered at set time points. This analysis specifically focuses on individuals who reported pain on the GIPP within an hour of drinking the test solution. Results: Of the overall sample (N=77) 22 patients reported abdominal discomfort on the GIPP within one hour of ingesting test solution. Almost 70% of patients with a prior history of chronic abdominal pain (n=25) had abdominal discomfort induced by the intestinal permeability test solution. Patients with a prior history of chronic abdominal pain were almost 20x (Exp (B) 19.98, p<.001) more likely to have symptoms of abdominal discomfort, as evidenced by the GIPP, in response to the intestinal permeability test solution. Conclusions: This study demonstrates that the IP test solution induced abdominal discomfort in patients with a prior history of chronic abdominal pain. Furthermore, the novel computerized assessment tool (GIPP) was able to capture this patient entered data in real time. The GIPP may have future application in discriminating differing patient pain profiles with ease of long term collection of both subjective and objective (physiological) patient related outcomes.
Keywords:
Abdominal pain; Gastrointestinal Pain Pointer; Intestinal permeability solution
Repository Posting Date:
20-Feb-2012
Date of Publication:
20-Feb-2012
Other Identifiers:
5701
Sponsors:
Western Institute of Nursing

Full metadata record

DC FieldValue Language
dc.typeResearch Studyen_GB
dc.titleABDOMINAL DISCOMFORT AFTER INGESTING INTESTINAL PERMEABILITY TEST SOLUTIONen_GB
dc.identifier.urihttp://hdl.handle.net/10755/211663-
dc.description.abstractBackground: Chronic abdominal pain is a common symptom reported in the United States. The Gastrointestinal Pain Pointer (GIPP) is a computerized tool designed to improve both subjective and objective data capture of abdominal discomfort in real-time. Aim: The purpose of this study was to profile patients who reported having abdominal discomfort on the GIPP within the first hour of drinking an intestinal permeability test solution. Methods: Individuals with chronic abdominal pain and healthy volunteers ages 13-45, overweight and healthy weight according to BMI, were recruited to a natural history protocol. After an overnight fast, blood was collected and individuals were asked to drink a 100 ml intestinal permeability test solution composed of lactulose, mannitol, sucralose, and sucrose. Individuals were then monitored for the next 5 hours during which all urine was collected and the GIPP was administered at set time points. This analysis specifically focuses on individuals who reported pain on the GIPP within an hour of drinking the test solution. Results: Of the overall sample (N=77) 22 patients reported abdominal discomfort on the GIPP within one hour of ingesting test solution. Almost 70% of patients with a prior history of chronic abdominal pain (n=25) had abdominal discomfort induced by the intestinal permeability test solution. Patients with a prior history of chronic abdominal pain were almost 20x (Exp (B) 19.98, p<.001) more likely to have symptoms of abdominal discomfort, as evidenced by the GIPP, in response to the intestinal permeability test solution. Conclusions: This study demonstrates that the IP test solution induced abdominal discomfort in patients with a prior history of chronic abdominal pain. Furthermore, the novel computerized assessment tool (GIPP) was able to capture this patient entered data in real time. The GIPP may have future application in discriminating differing patient pain profiles with ease of long term collection of both subjective and objective (physiological) patient related outcomes.en_GB
dc.subjectAbdominal painen_GB
dc.subjectGastrointestinal Pain Pointeren_GB
dc.subjectIntestinal permeability solutionen_GB
dc.date.available2012-02-20T12:07:05Z-
dc.date.issued2012-02-20T12:07:05Z-
dc.date.accessioned2012-02-20T12:07:05Z-
dc.description.sponsorshipWestern Institute of Nursingen_GB
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