Prevention of Radiation Induced Oral Mucositis in Head and Neck Cancer Patients: A Systematic Review

2.50
Hdl Handle:
http://hdl.handle.net/10755/243208
Category:
Abstract
Type:
Presentation
Title:
Prevention of Radiation Induced Oral Mucositis in Head and Neck Cancer Patients: A Systematic Review
Author(s):
Su, Wan-Tzu; Yang, Yueh-Ying; Fang, Yueh-Yen
Author Details:
Su, Wan-Tzu, BSN, RN, belle0722@gmail.com; Yang, Yueh-Ying, BSN, RN; Fang, Yueh-Yen, PhD, RN;
Abstract:
Purpose: This systematic review aims to examine the effectiveness of mouthrinse on preventing and treating radiation induced oral mucositis among head and neck cancer patients.

Methods: We systematically searched literature from five English (MEDLINE, PubMed, Cochrane Library, CINAHL, and ProQuest) and two Chinese (CEPS and Taiwan NDL Thesis and Dissertations) databases from 2001 to 2011. The search terms used were ‘head and neck cancer’, ‘mouthwash or mouthrinse’, ‘radiotherapy or irradiated’, and ‘oral mucositis’. A total of 493 articles were identified. Four RCTs and three CCTs met the inclusion criteria and analyzed by the current review. Research quality of reviewed studies was assessed by the Johns Hopkins Evidence-based Practice Quality Rating Scale.

Results: Research quality of included studies ranged from high to medium. Presence of different types and times of outcome measures impeded the quantitative integration of research evidence. Comparing to plain water, Chlorhexidine and PTA did not provide a better solution across studies. The effect of Benzydamine was not consistent across studies. Providone-iodine presented conflicted results between two studies. For those patients who received high dosage radiotherapy, none of any mouthrinse provided any preventive or therapeutic effect on oral mucositis.

Conclusion: Results of this systematic review revealed insufficient evidence to support the decision making on selection of effective mouthrinse for preventing or treating radiation induced oral mucocitis. Future studies are encouraged to include both measures of incidence and severity of oral mucocitis to ease the accumulation of research evidence.

Keywords:
head-and-neck cancer; mouthrinse; mucositis
Repository Posting Date:
12-Sep-2012
Date of Publication:
12-Sep-2012
Conference Date:
2012
Conference Name:
23rd International Nursing Research Congress
Conference Host:
Sigma Theta Tau International, the Honor Society of Nursing
Conference Location:
Brisbane, Australia

Full metadata record

DC FieldValue Language
dc.type.categoryAbstracten_GB
dc.typePresentationen_GB
dc.titlePrevention of Radiation Induced Oral Mucositis in Head and Neck Cancer Patients: A Systematic Reviewen_GB
dc.contributor.authorSu, Wan-Tzuen_GB
dc.contributor.authorYang, Yueh-Yingen_GB
dc.contributor.authorFang, Yueh-Yenen_GB
dc.author.detailsSu, Wan-Tzu, BSN, RN, belle0722@gmail.com; Yang, Yueh-Ying, BSN, RN; Fang, Yueh-Yen, PhD, RN;en_GB
dc.identifier.urihttp://hdl.handle.net/10755/243208-
dc.description.abstract<b>Purpose: </b>This systematic review aims to examine the effectiveness of mouthrinse on preventing and treating radiation induced oral mucositis among head and neck cancer patients. <p><b>Methods: </b>We systematically searched literature from five English (MEDLINE, PubMed, Cochrane Library, CINAHL, and ProQuest) and two Chinese (CEPS and Taiwan NDL Thesis and Dissertations) databases from 2001 to 2011. The search terms used were &lsquo;head and neck cancer&rsquo;, &lsquo;mouthwash or mouthrinse&rsquo;, &lsquo;radiotherapy or irradiated&rsquo;, and &lsquo;oral mucositis&rsquo;. A total of 493 articles were identified. Four RCTs and three CCTs met the inclusion criteria and analyzed by the current review. Research quality of reviewed studies was assessed by the Johns Hopkins Evidence-based Practice Quality Rating Scale. <p><b>Results: </b>Research quality of included studies ranged from high to medium. Presence of different types and times of outcome measures impeded the quantitative integration of research evidence. Comparing to plain water, Chlorhexidine and PTA did not provide a better solution across studies. The effect of Benzydamine was not consistent across studies. Providone-iodine presented conflicted results between two studies. For those patients who received high dosage radiotherapy, none of any mouthrinse provided any preventive or therapeutic effect on oral mucositis. <p><b>Conclusion: </b>Results of this systematic review revealed insufficient evidence to support the decision making on selection of effective mouthrinse for preventing or treating radiation induced oral mucocitis. Future studies are encouraged to include both measures of incidence and severity of oral mucocitis to ease the accumulation of research evidence.en_GB
dc.subjecthead-and-neck canceren_GB
dc.subjectmouthrinseen_GB
dc.subjectmucositisen_GB
dc.date.available2012-09-12T09:19:01Z-
dc.date.issued2012-09-12-
dc.date.accessioned2012-09-12T09:19:01Z-
dc.conference.date2012en_GB
dc.conference.name23rd International Nursing Research Congressen_GB
dc.conference.hostSigma Theta Tau International, the Honor Society of Nursingen_GB
dc.conference.locationBrisbane, Australiaen_GB
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