Adapting and Testing an Evidence-Based Antiretroviral Medication Adherence Intervention in China

2.50
Hdl Handle:
http://hdl.handle.net/10755/303962
Category:
Full-text
Type:
Presentation
Title:
Adapting and Testing an Evidence-Based Antiretroviral Medication Adherence Intervention in China
Author(s):
Williams, Ann Bartley; Fennie, Kristopher P.; Li, Xian Hong; Burgess, Jane; Wang, Hong Hong
Lead Author STTI Affiliation:
Gamma Tau
Author Details:
Ann Bartley Williams, EdD, RN, awilliams@sonnet.ucla.edu; Kristopher P. Fennie, MPH, PhD; Xian Hong Li, PhD, RN; Jane Burgess, MS, RN, ACRN; Hong Hong Wang, PhD, RN;
Abstract:

Session presented on: Thursday, July 25, 2013

Purpose: To test the effectiveness of a culturally adapted evidence-based home nursing intervention to improve adherence to antiretroviral medications among people living with HIV/AIDS (PLWH/A) in Hunan, China.

Methods: In a randomized, controlled trial, 114 subjects were assigned to receive a culturally adapted intervention consisting of monthly visits and interim phone calls plus standard care or standard care alone. The intervention previously demonstrated efficacy in a randomized clinical trial conducted in the United States. All subjects were residents of Hunan, China, living with HIV/AIDS and self-reporting less than 90% adherence to prescribed medications. Measures included a 7-day visual analogue medication adherence scale, a social support rating scale, the Chinese version of the Center for Epidemiological Studies Depression scale Chinese, and an HIV/AIDS stigma scale. Data were collected in structured face-to-face interviews at baseline, 6 months, and 12 months at the time of a regularly scheduled clinical visit. Information regarding ARV regimen, treatment duration, time of diagnosis, CD4 count and HIV-RNA was extracted from the medical record.

Results: Subjects were 72% male (N=82); 52% (N=59) married; and only 28% (N=32) stably employed. Thirty-one percent (N=35) reported past or current drug abuse. The great majority (98%) had a CD4 count at baseline that was less than 350 cells/mm3. At 6 months and 12 months, a greater proportion of subjects in the intervention group self-reported 'adherence greater than 90% compared to the control group.' The difference over time is significant (Extended Mantel-Haenszel Test:' 8.8, p=.003).

Conclusions: In spite of significant cultural differences, evidence-based interventions can be implemented effectively in new settings and with new populations.

Keywords:
home nursing intervention; HIV/AIDS; medication adherence
Repository Posting Date:
22-Oct-2013
Date of Publication:
22-Oct-2013 ; 22-Oct-2013
Conference Date:
2013
Conference Name:
24th International Nursing Research Congress
Conference Host:
Sigma Theta Tau International, the Honor Society of Nursing
Conference Location:
Prague, Czech Republic
Description:
24th International Nursing Research Congress Theme: Bridge the Gap Between Research and Practice Through Collaboration. Held at the Hilton Prague Hotel.

Full metadata record

DC FieldValue Language
dc.language.isoen_USen_GB
dc.language.isoenen
dc.type.categoryFull-texten
dc.typePresentationen
dc.titleAdapting and Testing an Evidence-Based Antiretroviral Medication Adherence Intervention in Chinaen
dc.contributor.authorWilliams, Ann Bartleyen
dc.contributor.authorFennie, Kristopher P.en
dc.contributor.authorLi, Xian Hongen
dc.contributor.authorBurgess, Janeen
dc.contributor.authorWang, Hong Hongen
dc.contributor.departmentGamma Tauen
dc.author.detailsAnn Bartley Williams, EdD, RN, awilliams@sonnet.ucla.edu; Kristopher P. Fennie, MPH, PhD; Xian Hong Li, PhD, RN; Jane Burgess, MS, RN, ACRN; Hong Hong Wang, PhD, RN;en
dc.identifier.urihttp://hdl.handle.net/10755/303962-
dc.description.abstract<p>Session presented on: Thursday, July 25, 2013</p><b>Purpose: </b> To test the effectiveness of a culturally adapted evidence-based home nursing intervention to improve adherence to antiretroviral medications among people living with HIV/AIDS (PLWH/A) in Hunan, China. <p><b>Methods: </b> In a randomized, controlled trial, 114 subjects were assigned to receive a culturally adapted intervention consisting of monthly visits and interim phone calls plus standard care or standard care alone. The intervention previously demonstrated efficacy in a randomized clinical trial conducted in the United States. All subjects were residents of Hunan, China, living with HIV/AIDS and self-reporting less than 90% adherence to prescribed medications. Measures included a 7-day visual analogue medication adherence scale, a social support rating scale, the Chinese version of the Center for Epidemiological Studies Depression scale Chinese, and an HIV/AIDS stigma scale. Data were collected in structured face-to-face interviews at baseline, 6 months, and 12 months at the time of a regularly scheduled clinical visit. Information regarding ARV regimen, treatment duration, time of diagnosis, CD4 count and HIV-RNA was extracted from the medical record. <p><b>Results: </b> Subjects were 72% male (N=82); 52% (N=59) married; and only 28% (N=32) stably employed. Thirty-one percent (N=35) reported past or current drug abuse. The great majority (98%) had a CD4 count at baseline that was less than 350 cells/mm3. At 6 months and 12 months, a greater proportion of subjects in the intervention group self-reported 'adherence greater than 90% compared to the control group.' The difference over time is significant (Extended Mantel-Haenszel Test:' 8.8, p=.003). <p><b>Conclusions: </b> In spite of significant cultural differences, evidence-based interventions can be implemented effectively in new settings and with new populations.en
dc.subjecthome nursing interventionen
dc.subjectHIV/AIDSen
dc.subjectmedication adherenceen
dc.date.available2013-10-22T20:26:41Z-
dc.date.issued2013-10-22-
dc.date.issued2013-10-22en
dc.date.accessioned2013-10-22T20:26:41Z-
dc.conference.date2013en
dc.conference.name24th International Nursing Research Congressen
dc.conference.hostSigma Theta Tau International, the Honor Society of Nursingen
dc.conference.locationPrague, Czech Republicen
dc.description24th International Nursing Research Congress Theme: Bridge the Gap Between Research and Practice Through Collaboration. Held at the Hilton Prague Hotel.en
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