Pathways to Obesity: Implications of a Shifting Obesity Paradigm for Nursing Research

2.50
Hdl Handle:
http://hdl.handle.net/10755/304076
Category:
Full-text
Type:
Presentation
Title:
Pathways to Obesity: Implications of a Shifting Obesity Paradigm for Nursing Research
Author(s):
Rogge, Mary Madeline
Lead Author STTI Affiliation:
Iota Mu
Author Details:
Mary Madeline Rogge, PhD, RN, FNP, BC, mary.rogge@ttuhsc.edu
Abstract:

Session presented on: Tuesday, July 23, 2013

Purpose: Obesity is recognized as a global health problem.' The calories in-calories out paradigm of obesity has been only marginally successful in preventing or treating obesity, and fails to explain why some people overeat or under-exercise.' The purpose of the research was to identify and organize a new conceptual model of factors associated with the development and progression of obesity based on the pathophysiological bases for these associations.

Methods: Theory synthesis was utilized to organize research findings of adipogenic factors into a model of obesity pathophysiology. ''A literature review based on search terms 'obesity etiology,' 'obesity pathophysiology,' and 'adipogenesis' was conducted to identify defects in energy homeostasis which may account for excess fat accumulation.

Results: Three pathways were identified by which energy homeostasis may be involuntarily disrupted through genetic and epigenetic influences.' Adipose cell dysfunction includes excess adipose cell proliferation due to activation of gene transcription factors (thiazolidinediones, adenovirus-36, fatty acids), and impaired fatty acid liberation and thermogenesis due to beta-adrenergic receptor polymorphisms, and decreased brown fat mass.' Neuroendocrine hunger and satiety pathways may be disrupted due to factors including hyperinsulinemia, melanocortin receptor polymorphisms and anti-melanocortin receptor autoantibodies, stress, sleep deprivation, and medications (antihistamines, antipsychotic drugs). Mitochondrial impairment in converting food substrates into cellular energy may result from impaired beta-oxidation of fatty acids, disruption of the tricarboxcylic acid cycle by medications (certain beta adrenergic blockers, tricyclic antidepressants), and environmental exposures (atrazine, dioxin, persistent organic pollutants). 'The Pathways to Obesity Model was constructed to show the inter-relationships between these patterns of obesity etiology. '''

Conclusion: The model provides a new framework for assessing patients and for designing and researching different approaches to obesity prevention and management based on the underlying etiology and pathophysiology.

Keywords:
nursing; obesity; pathophysiology
Repository Posting Date:
22-Oct-2013
Date of Publication:
22-Oct-2013 ; 22-Oct-2013
Conference Date:
2013
Conference Name:
24th International Nursing Research Congress
Conference Host:
Sigma Theta Tau International, the Honor Society of Nursing
Conference Location:
Prague, Czech Republic
Description:
24th International Nursing Research Congress Theme: Bridge the Gap Between Research and Practice Through Collaboration. Held at the Hilton Prague Hotel.

Full metadata record

DC FieldValue Language
dc.language.isoen_USen_GB
dc.language.isoenen
dc.type.categoryFull-texten
dc.typePresentationen
dc.titlePathways to Obesity: Implications of a Shifting Obesity Paradigm for Nursing Researchen
dc.contributor.authorRogge, Mary Madelineen
dc.contributor.departmentIota Muen
dc.author.detailsMary Madeline Rogge, PhD, RN, FNP, BC, mary.rogge@ttuhsc.eduen
dc.identifier.urihttp://hdl.handle.net/10755/304076-
dc.description.abstract<p>Session presented on: Tuesday, July 23, 2013</p><b>Purpose: </b> Obesity is recognized as a global health problem.' The calories in-calories out paradigm of obesity has been only marginally successful in preventing or treating obesity, and fails to explain why some people overeat or under-exercise.' The purpose of the research was to identify and organize a new conceptual model of factors associated with the development and progression of obesity based on the pathophysiological bases for these associations. <p><b>Methods: </b>Theory synthesis was utilized to organize research findings of adipogenic factors into a model of obesity pathophysiology. ''A literature review based on search terms 'obesity etiology,' 'obesity pathophysiology,' and 'adipogenesis' was conducted to identify defects in energy homeostasis which may account for excess fat accumulation. <p><b>Results: </b>Three pathways were identified by which energy homeostasis may be involuntarily disrupted through genetic and epigenetic influences.' Adipose cell dysfunction includes excess adipose cell proliferation due to activation of gene transcription factors (thiazolidinediones, adenovirus-36, fatty acids), and impaired fatty acid liberation and thermogenesis due to beta-adrenergic receptor polymorphisms, and decreased brown fat mass.' Neuroendocrine hunger and satiety pathways may be disrupted due to factors including hyperinsulinemia, melanocortin receptor polymorphisms and anti-melanocortin receptor autoantibodies, stress, sleep deprivation, and medications (antihistamines, antipsychotic drugs). Mitochondrial impairment in converting food substrates into cellular energy may result from impaired beta-oxidation of fatty acids, disruption of the tricarboxcylic acid cycle by medications (certain beta adrenergic blockers, tricyclic antidepressants), and environmental exposures (atrazine, dioxin, persistent organic pollutants). 'The Pathways to Obesity Model was constructed to show the inter-relationships between these patterns of obesity etiology. ''' <p><b>Conclusion: </b>The model provides a new framework for assessing patients and for designing and researching different approaches to obesity prevention and management based on the underlying etiology and pathophysiology.en
dc.subjectnursingen
dc.subjectobesityen
dc.subjectpathophysiologyen
dc.date.available2013-10-22T20:28:45Z-
dc.date.issued2013-10-22-
dc.date.issued2013-10-22en
dc.date.accessioned2013-10-22T20:28:45Z-
dc.conference.date2013en
dc.conference.name24th International Nursing Research Congressen
dc.conference.hostSigma Theta Tau International, the Honor Society of Nursingen
dc.conference.locationPrague, Czech Republicen
dc.description24th International Nursing Research Congress Theme: Bridge the Gap Between Research and Practice Through Collaboration. Held at the Hilton Prague Hotel.en
All Items in this repository are protected by copyright, with all rights reserved, unless otherwise indicated.