Asthma Therapy in Pediatric Patients: A Systematic Review Comparing Montelukast and Inhaled Corticosteroids

2.50
Hdl Handle:
http://hdl.handle.net/10755/308264
Category:
Abstract
Type:
Presentation
Title:
Asthma Therapy in Pediatric Patients: A Systematic Review Comparing Montelukast and Inhaled Corticosteroids
Author(s):
Massingham, Kristen L
Lead Author STTI Affiliation:
Alpha Zeta
Author Details:
Kristen L Massingham, MSN, CPNP, RN, krismass3@yahoo.com
Abstract:

Poster presented on: Sunday, November 17, 2013, Saturday, November 16, 2013

Purpose:To examine current research on treatment of mild-moderate persistent asthma using monotherapy with either montelukast or inhaled corticosteroids.

Introduction: Asthma is the most common chronic illness in the pediatric population.  Inhaled corticosteroids (ICS) are a first-line treatment for mild-moderate persistent asthma, but leukotriene receptor antagonists such as montelukast have been shown to be beneficial. The aim of this systematic review is to evaluate the current evidence comparing monotherapy with montelukast or inhaled corticosteroids in pediatric patients. 

Method: A systematic review was conducted following the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) guidelines to evaluate treatment of children with mild-moderate persistent asthma using monotherapy with either montelukast or inhaled corticosteroids in patients ages 2-18 years.  PubMed, CINAHL and the Institute of Scientific Information’s Web of Knowledge were searched independently by three reviewers using keywords asthma, montelukast, and inhaled corticosteroids.  In order to capture current data, the search was conducted between January 2002-November 2011.  Inclusion criteria included randomized controlled trials published in the English language. The quality of each study was evaluated by two reviewers. 

Results: A total of 214 studies were identified and 8 randomized controlled trials met our inclusion criteria and were included in the review.  Seven out of eight studies showed high quality.  The primary outcome measures assessed include forced expiratory volume in 1 second, peak expiratory flow rate, time to asthma exacerbations, number of exacerbations, number of asthma free days, and daily symptom scores. Four studies showed statistically significant results favoring inhaled corticosteroid therapy over montelukast.  Four studies showed no difference between inhaled corticosteroids and montelukast.

Conclusion/Implications: Inhaled corticosteroids remain superior to montelukast as a preferred  first-line treatment for asthma.  However, montelukast may be an effective alternative for specific cases in improving pulmonary function in patients with specific asthma phenotypes in the pediatric setting.

Keywords:
asthma; inhaled corticosteroids; montelukast
Repository Posting Date:
19-Dec-2013
Date of Publication:
19-Dec-2013
Conference Date:
2013
Conference Name:
42nd Biennial Convention
Conference Host:
Sigma Theta Tau International, the Honor Society of Nursing
Conference Location:
Indianapolis, Indiana, USA
Description:
42nd Biennial Convention 2013 Theme: Give Back to Move Forward. Held at the JW Marriott
Note:
This is an abstract-only submission. If the author has submitted a full-text item based on this abstract, you may find it by browsing the Virginia Henderson Global Nursing e-Repository by author. If author contact information is available in this abstract, please feel free to contact him or her with your queries regarding this submission.

Full metadata record

DC FieldValue Language
dc.language.isoen_USen_GB
dc.type.categoryAbstracten_GB
dc.typePresentationen_GB
dc.titleAsthma Therapy in Pediatric Patients: A Systematic Review Comparing Montelukast and Inhaled Corticosteroidsen_GB
dc.contributor.authorMassingham, Kristen Len_GB
dc.contributor.departmentAlpha Zetaen_GB
dc.author.detailsKristen L Massingham, MSN, CPNP, RN, krismass3@yahoo.comen_GB
dc.identifier.urihttp://hdl.handle.net/10755/308264-
dc.description.abstract<p>Poster presented on: Sunday, November 17, 2013, Saturday, November 16, 2013</p><b>Purpose:</b>To examine current research on treatment of mild-moderate persistent asthma using monotherapy with either montelukast or inhaled corticosteroids. <p><b>Introduction:</b><i> </i>Asthma is the most common chronic illness in the pediatric population.  Inhaled corticosteroids (ICS) are a first-line treatment for mild-moderate persistent asthma, but leukotriene receptor antagonists such as montelukast have been shown to be beneficial. The aim of this systematic review is to evaluate the current evidence comparing monotherapy with montelukast or inhaled corticosteroids in pediatric patients.  <i></i><p><b>Method:</b><i> </i>A systematic review was conducted following the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) guidelines to evaluate treatment of children with mild-moderate persistent asthma using monotherapy with either montelukast or inhaled corticosteroids in patients ages 2-18 years.  PubMed, CINAHL and the Institute of Scientific Information’s Web of Knowledge were searched independently by three reviewers using keywords asthma, montelukast, and inhaled corticosteroids.  In order to capture current data, the search was conducted between January 2002-November 2011.  Inclusion criteria included randomized controlled trials published in the English language. The quality of each study was evaluated by two reviewers.  <i></i><p><b>Results:</b><i> </i>A total of 214 studies were identified and 8 randomized controlled trials met our inclusion criteria and were included in the review.  Seven out of eight studies showed high quality.  The primary outcome measures assessed include forced expiratory volume in 1 second, peak expiratory flow rate, time to asthma exacerbations, number of exacerbations, number of asthma free days, and daily symptom scores. Four studies showed statistically significant results favoring inhaled corticosteroid therapy over montelukast.  Four studies showed no difference between inhaled corticosteroids and montelukast.<i></i><p><b>Conclusion/Implications:</b> Inhaled corticosteroids remain superior to montelukast as a preferred  first-line treatment for asthma.  However, montelukast may be an effective alternative for specific cases in improving pulmonary function in patients with specific asthma phenotypes in the pediatric setting.en_GB
dc.subjectasthmaen_GB
dc.subjectinhaled corticosteroidsen_GB
dc.subjectmontelukasten_GB
dc.date.available2013-12-19T17:29:02Z-
dc.date.issued2013-12-19-
dc.date.accessioned2013-12-19T17:29:02Z-
dc.conference.date2013en_GB
dc.conference.name42nd Biennial Conventionen_GB
dc.conference.hostSigma Theta Tau International, the Honor Society of Nursingen_GB
dc.conference.locationIndianapolis, Indiana, USAen_GB
dc.description42nd Biennial Convention 2013 Theme: Give Back to Move Forward. Held at the JW Marriotten_GB
dc.description.noteThis is an abstract-only submission. If the author has submitted a full-text item based on this abstract, you may find it by browsing the Virginia Henderson Global Nursing e-Repository by author. If author contact information is available in this abstract, please feel free to contact him or her with your queries regarding this submission.en_GB
All Items in this repository are protected by copyright, with all rights reserved, unless otherwise indicated.