Serotonergic Antidepressants and Perioperative Bleeding Risk in Patients Undergoing Total Knee Arthroplasty

2.50
Hdl Handle:
http://hdl.handle.net/10755/308328
Category:
Abstract
Type:
Presentation
Title:
Serotonergic Antidepressants and Perioperative Bleeding Risk in Patients Undergoing Total Knee Arthroplasty
Author(s):
Thottam, Mary. R.; Mancuso, Peggy J.
Lead Author STTI Affiliation:
Beta Beta
Author Details:
Mary. R. Thottam, MSN, BSN, RN, marythottam@yahoo.com; Peggy J. Mancuso, PhD, RN, CNM
Abstract:

Poster presented on: Sunday, November 17, 2013, Saturday, November 16, 2013

Abstract

Background: Serotonergic antidepressants are one of the most extensively prescribed classes of drugs used for the treatment of depression, obsessive-compulsive disorder, anxiety disorders and a variety of other psychiatric disorders.  Although these drugs have been known to exhibit a favorable safety profile, numerous studies have reported an association between serotonergic antidepressant uses and increased bleeding. However, data on effect of serotonergic antidepressants on perioperative bleeding risk is limited and conflicting, and its clinical relevance to perioperative care is uncertain.

Objective: This study aimed to determine the association between the preoperative use of serotonergic antidepressants and excessive bleeding during total knee arthroplasty.

Methodology: A retrospective analysis was conducted of 80 patients who underwent elective primary total knee arthroplasty in a large Veterans Affairs hospital. The index group included 40 patients who used serotonergic antidepressants in the preceding 4 weeks prior to surgery, and the reference group included 40 patients who were nonusers. The primary outcome was the change in hematocrit; and the secondary outcomes were the amount of estimated blood loss and the requirement for blood transfusion.

Results: This study found no significant association between current preoperative use of serotonergic antidepressants and the variables of change in hematocrit, estimated blood loss and the requirement of blood transfusion.

Conclusion: This retrospective clinical inquiry of patients undergoing total knee arthroplasty who continued to use serotonergic antidepressants did not show a significantly higher perioperative blood loss. It was however noted that patients on serotonergic antidepressants had significantly lower preoperative hemoglobin and hematocrit, and in view of this association warrants further research.

Keywords:
Perioperative bleeding; Estimated blood loss; Serotonergic Antidepressants
Repository Posting Date:
19-Dec-2013
Date of Publication:
19-Dec-2013
Conference Date:
2013
Conference Name:
42nd Biennial Convention
Conference Host:
Sigma Theta Tau International, the Honor Society of Nursing
Conference Location:
Indianapolis, Indiana, USA
Description:
42nd Biennial Convention 2013 Theme: Give Back to Move Forward. Held at the JW Marriott
Note:
This is an abstract-only submission. If the author has submitted a full-text item based on this abstract, you may find it by browsing the Virginia Henderson Global Nursing e-Repository by author. If author contact information is available in this abstract, please feel free to contact him or her with your queries regarding this submission.

Full metadata record

DC FieldValue Language
dc.language.isoen_USen_GB
dc.type.categoryAbstracten_GB
dc.typePresentationen_GB
dc.titleSerotonergic Antidepressants and Perioperative Bleeding Risk in Patients Undergoing Total Knee Arthroplastyen_GB
dc.contributor.authorThottam, Mary. R.en_GB
dc.contributor.authorMancuso, Peggy J.en_GB
dc.contributor.departmentBeta Betaen_GB
dc.author.detailsMary. R. Thottam, MSN, BSN, RN, marythottam@yahoo.com; Peggy J. Mancuso, PhD, RN, CNMen_GB
dc.identifier.urihttp://hdl.handle.net/10755/308328-
dc.description.abstract<p>Poster presented on: Sunday, November 17, 2013, Saturday, November 16, 2013</p><b>Abstract</b><p><b>Background</b>: Serotonergic antidepressants are one of the most extensively prescribed classes of drugs used for the treatment of depression, obsessive-compulsive disorder, anxiety disorders and a variety of other psychiatric disorders.  Although these drugs have been known to exhibit a favorable safety profile, numerous studies have reported an association between serotonergic antidepressant uses and increased bleeding. However, data on effect of serotonergic antidepressants on perioperative bleeding risk is limited and conflicting, and its clinical relevance to perioperative care is uncertain. <p><b>Objective</b>: This study aimed to determine the association between the preoperative use of serotonergic antidepressants and excessive bleeding during total knee arthroplasty. <p><b>Methodology</b>: A retrospective analysis was conducted of 80 patients who underwent elective primary total knee arthroplasty in a large Veterans Affairs hospital. The index group included 40 patients who used serotonergic antidepressants in the preceding 4 weeks prior to surgery, and the reference group included 40 patients who were nonusers. The primary outcome was the change in hematocrit; and the secondary outcomes were the amount of estimated blood loss and the requirement for blood transfusion. <p><strong>Results</strong>: This study found no significant association between current preoperative use of serotonergic antidepressants and the variables of change in hematocrit, estimated blood loss and the requirement of blood transfusion. <p><b>Conclusion</b>: This retrospective clinical inquiry of patients undergoing total knee arthroplasty who continued to use serotonergic antidepressants did not show a significantly higher perioperative blood loss. It was however noted that patients on serotonergic antidepressants had significantly lower preoperative hemoglobin and hematocrit, and in view of this association warrants further research.en_GB
dc.subjectPerioperative bleedingen_GB
dc.subjectEstimated blood lossen_GB
dc.subjectSerotonergic Antidepressantsen_GB
dc.date.available2013-12-19T17:29:53Z-
dc.date.issued2013-12-19-
dc.date.accessioned2013-12-19T17:29:53Z-
dc.conference.date2013en_GB
dc.conference.name42nd Biennial Conventionen_GB
dc.conference.hostSigma Theta Tau International, the Honor Society of Nursingen_GB
dc.conference.locationIndianapolis, Indiana, USAen_GB
dc.description42nd Biennial Convention 2013 Theme: Give Back to Move Forward. Held at the JW Marriotten_GB
dc.description.noteThis is an abstract-only submission. If the author has submitted a full-text item based on this abstract, you may find it by browsing the Virginia Henderson Global Nursing e-Repository by author. If author contact information is available in this abstract, please feel free to contact him or her with your queries regarding this submission.en_GB
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