The Biological Implications of Chronic Circadian Misalignment in Pregnancy: Is there a Link to Poor Birth Outcomes?

2.50
Hdl Handle:
http://hdl.handle.net/10755/308377
Category:
Abstract
Type:
Presentation
Title:
The Biological Implications of Chronic Circadian Misalignment in Pregnancy: Is there a Link to Poor Birth Outcomes?
Author(s):
Dunn, Alexis B; Rogers, Ann E.; Corwin, Elizabeth
Lead Author STTI Affiliation:
Alpha Epsilon
Author Details:
Alexis B Dunn, MSN, APRN, CNM, alexis.b.dunn@emory.edu; Ann E. Rogers, PhD, RN, FAAN; Elizabeth Corwin, RN, PhD, FNP
Abstract:

Poster presented on: Saturday, November 16, 2013, Sunday, November 17, 2013

Purpose

A theoretical framework is proposed to explain how chronic circadian misalignment (CCM) may contribute to adverse birth outcomes.  CCM refers to abnormal neuroendocrine activity resulting from chronic sleep disruption. Peripheral circadian clocks exist in reproductive and immune tissues and coordinate ovulation, implantation, and pregnancy maintenance. Peripheral circadian clocks are controlled by the master circadian pacemaker in the hypothalamus.  Research indicates shift work may lead to CCM thereby influencing pregnancy outcomes.

Methods:  

A narrative review identified relationships between circadian rhythms, shiftwork, and birth outcomes.  Findings were compared, themes synthesized, and limitations reviewed. The Bollinger sleep- immune model was used in conjunction with the reproductive circadian literature to explore associations between sleep, immunity, and reproduction.

Results:

Narrative review identified knowledge deficits and advances in the study of CCM in relation to birth outcomes.  Altered sleep and abnormal exposure to light were found to affect synchronization of the master circadian pacemaker with peripheral sites. From this, CCM may develop and contribute to immune dysregulation and reproductive consequences including altered fertility, menstrual irregularities, and decreased term pregnancy.

Conclusions:   This theory provides a framework for how inflammation may develop from CCM and influence birth outcomes. Further clarification of theoretical linkage between CCM and reproductive outcomes will shed light on how the environment impacts health, fertility, and reproduction.

Keywords:
preterm labor; shiftwork; circadian clock
Repository Posting Date:
19-Dec-2013
Date of Publication:
19-Dec-2013
Conference Date:
2013
Conference Name:
42nd Biennial Convention
Conference Host:
Sigma Theta Tau International, the Honor Society of Nursing
Conference Location:
Indianapolis, Indiana, USA
Description:
42nd Biennial Convention 2013 Theme: Give Back to Move Forward. Held at the JW Marriott
Note:
This is an abstract-only submission. If the author has submitted a full-text item based on this abstract, you may find it by browsing the Virginia Henderson Global Nursing e-Repository by author. If author contact information is available in this abstract, please feel free to contact him or her with your queries regarding this submission.

Full metadata record

DC FieldValue Language
dc.language.isoen_USen_GB
dc.type.categoryAbstracten_GB
dc.typePresentationen_GB
dc.titleThe Biological Implications of Chronic Circadian Misalignment in Pregnancy: Is there a Link to Poor Birth Outcomes?en_GB
dc.contributor.authorDunn, Alexis Ben_GB
dc.contributor.authorRogers, Ann E.en_GB
dc.contributor.authorCorwin, Elizabethen_GB
dc.contributor.departmentAlpha Epsilonen_GB
dc.author.detailsAlexis B Dunn, MSN, APRN, CNM, alexis.b.dunn@emory.edu; Ann E. Rogers, PhD, RN, FAAN; Elizabeth Corwin, RN, PhD, FNPen_GB
dc.identifier.urihttp://hdl.handle.net/10755/308377-
dc.description.abstract<p>Poster presented on: Saturday, November 16, 2013, Sunday, November 17, 2013</p><b>Purpose </b><p>A theoretical framework is proposed to explain how chronic circadian misalignment (CCM) may contribute to adverse birth outcomes.  CCM refers to abnormal neuroendocrine activity resulting from chronic sleep disruption. Peripheral circadian clocks exist in reproductive and immune tissues and coordinate ovulation, implantation, and pregnancy maintenance. Peripheral circadian clocks are controlled by the master circadian pacemaker in the hypothalamus.  Research indicates shift work may lead to CCM thereby influencing pregnancy outcomes. <p><b>Methods:  </b><p>A narrative review identified relationships between circadian rhythms, shiftwork, and birth outcomes.  Findings were compared, themes synthesized, and limitations reviewed. The Bollinger sleep- immune model was used in conjunction with the reproductive circadian literature to explore associations between sleep, immunity, and reproduction. <p><b>Results: </b><p>Narrative review identified knowledge deficits and advances in the study of CCM in relation to birth outcomes.  Altered sleep and abnormal exposure to light were found to affect synchronization of the master circadian pacemaker with peripheral sites. From this, CCM may develop and contribute to immune dysregulation and reproductive consequences including altered fertility, menstrual irregularities, and decreased term pregnancy. <p><b>Conclusions</b>:   This theory provides a framework for how inflammation may develop from CCM and influence birth outcomes. Further clarification of theoretical linkage between CCM and reproductive outcomes will shed light on how the environment impacts health, fertility, and reproduction.en_GB
dc.subjectpreterm laboren_GB
dc.subjectshiftworken_GB
dc.subjectcircadian clocken_GB
dc.date.available2013-12-19T17:30:32Z-
dc.date.issued2013-12-19-
dc.date.accessioned2013-12-19T17:30:32Z-
dc.conference.date2013en_GB
dc.conference.name42nd Biennial Conventionen_GB
dc.conference.hostSigma Theta Tau International, the Honor Society of Nursingen_GB
dc.conference.locationIndianapolis, Indiana, USAen_GB
dc.description42nd Biennial Convention 2013 Theme: Give Back to Move Forward. Held at the JW Marriotten_GB
dc.description.noteThis is an abstract-only submission. If the author has submitted a full-text item based on this abstract, you may find it by browsing the Virginia Henderson Global Nursing e-Repository by author. If author contact information is available in this abstract, please feel free to contact him or her with your queries regarding this submission.en_GB
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