Meta-Analyses of Epigenetics Risk Factors for Heart Disease Prevention: NOS3 Human Gene Variations Across Different Race-Ethnicity Groups

2.50
Hdl Handle:
http://hdl.handle.net/10755/335205
Category:
Full-text
Type:
Presentation
Title:
Meta-Analyses of Epigenetics Risk Factors for Heart Disease Prevention: NOS3 Human Gene Variations Across Different Race-Ethnicity Groups
Other Titles:
Symposium: Meta-Analyses of Human Genome Studies: Epigenetic Risk Factors and Population Health Issues in the World
Author(s):
Chang, Nien-Tzu; Delacruz, Lisa; Shiao, Shyang-Yun Pamela K.
Lead Author STTI Affiliation:
Iota Sigma
Author Details:
Nien-Tzu Chang, PhD, RN, ntchang@ntu.edu.tw; Lisa Delacruz, MN, RN; Shyang-Yun Pamela K. Shiao, PhD, RN, FAAN
Abstract:
Session presented on Monday, July 28, 2014: Purpose: The purpose of this presentation is to disseminate current evidence on population genome health, through meta-analyses of epigenetic risk factors, for heart disease prevention. Ischemic heart disease (IHD) is the major leading cause of deaths worldwide. Epidemiological studies have revealed the association between nitric oxide synthase 3 (NOS3) gene mutation variations with increased risks of IHD in various populations in the world. NOS3 is a gene affects metabolism in the urea cycle of the methylation pathways, critical for preventing systematic inflammation as an epigenetics risk factor for heart health. Methods: Literature searches, quality scores for the studies, and inter-rater evaluation on data coding was completed to ensure data accuracy for pooled meta-analyses. Results: Preliminary analyses include a total of 49 case-control studies with13,830 cases and 10,595 controls. The gene mutation variations (GT and TT subtypes) were higher in Caucasians (47.5-64.8%) than Africans (42.9-55.9%), Eurasians (33.9-45.1%), and Asians (13.5-30.7%) across the world, for control and case groups. Pollutions in the world were documented worse in selected European countries from 2004-2009, and in Asia in recent years. Pollution particles smaller than 2.5 micrometers, PM2.5, can pass through lungs, leading to plaque deposits in cardiovascular systems causing systematic inflammation. For lifestyle related meta-analyses, smoking was associated with an increased risk of IHD (24 studies, 6,889 cases, 5,685 controls, RR=1.68, 95% Confidence Interval = 1.39-2.04, p < 0.0001). The history of diabetes mellitus (RR=3.16, 2.4-4.17, P<0.0001) and hyperlipidemia (RR=2.92, 1.97-4.33, p<0.0001) were associated with IHD. Conclusion: Wild-type GG subtype (52.5% cases, 59.3% controls) was protective against IHD for all populations combined (RR = 0.92, 0.89-0.96, p < 0.0001). Future studies are needed to investigate the interactions between epigenetic risk factors, through methylation pathways, and NOS3 gene variations for cardiovascular health in various populations to prevent IHD.
Keywords:
epigenetics; heart-health; meta-analyses
Repository Posting Date:
17-Nov-2014
Date of Publication:
17-Nov-2014 ; 17-Nov-2014
Other Identifiers:
INRC14M11
Conference Date:
2014
Conference Name:
25th International Nursing Research Congress
Conference Host:
Sigma Theta Tau International, the Honor Society of Nursing
Conference Location:
Hong Kong
Description:
International Nursing Research Congress, 2014 Theme: Engaging Colleagues: Improving Global Health Outcomes. Held at the Hong Kong Convention and Exhibition Centre, Wanchai, Hong Kong

Full metadata record

DC FieldValue Language
dc.language.isoen_USen_GB
dc.language.isoenen
dc.type.categoryFull-texten
dc.typePresentationen
dc.titleMeta-Analyses of Epigenetics Risk Factors for Heart Disease Prevention: NOS3 Human Gene Variations Across Different Race-Ethnicity Groupsen
dc.title.alternativeSymposium: Meta-Analyses of Human Genome Studies: Epigenetic Risk Factors and Population Health Issues in the Worlden
dc.contributor.authorChang, Nien-Tzuen
dc.contributor.authorDelacruz, Lisaen
dc.contributor.authorShiao, Shyang-Yun Pamela K.en
dc.contributor.departmentIota Sigmaen
dc.author.detailsNien-Tzu Chang, PhD, RN, ntchang@ntu.edu.tw; Lisa Delacruz, MN, RN; Shyang-Yun Pamela K. Shiao, PhD, RN, FAANen
dc.identifier.urihttp://hdl.handle.net/10755/335205-
dc.description.abstractSession presented on Monday, July 28, 2014: Purpose: The purpose of this presentation is to disseminate current evidence on population genome health, through meta-analyses of epigenetic risk factors, for heart disease prevention. Ischemic heart disease (IHD) is the major leading cause of deaths worldwide. Epidemiological studies have revealed the association between nitric oxide synthase 3 (NOS3) gene mutation variations with increased risks of IHD in various populations in the world. NOS3 is a gene affects metabolism in the urea cycle of the methylation pathways, critical for preventing systematic inflammation as an epigenetics risk factor for heart health. Methods: Literature searches, quality scores for the studies, and inter-rater evaluation on data coding was completed to ensure data accuracy for pooled meta-analyses. Results: Preliminary analyses include a total of 49 case-control studies with13,830 cases and 10,595 controls. The gene mutation variations (GT and TT subtypes) were higher in Caucasians (47.5-64.8%) than Africans (42.9-55.9%), Eurasians (33.9-45.1%), and Asians (13.5-30.7%) across the world, for control and case groups. Pollutions in the world were documented worse in selected European countries from 2004-2009, and in Asia in recent years. Pollution particles smaller than 2.5 micrometers, PM2.5, can pass through lungs, leading to plaque deposits in cardiovascular systems causing systematic inflammation. For lifestyle related meta-analyses, smoking was associated with an increased risk of IHD (24 studies, 6,889 cases, 5,685 controls, RR=1.68, 95% Confidence Interval = 1.39-2.04, p < 0.0001). The history of diabetes mellitus (RR=3.16, 2.4-4.17, P<0.0001) and hyperlipidemia (RR=2.92, 1.97-4.33, p<0.0001) were associated with IHD. Conclusion: Wild-type GG subtype (52.5% cases, 59.3% controls) was protective against IHD for all populations combined (RR = 0.92, 0.89-0.96, p < 0.0001). Future studies are needed to investigate the interactions between epigenetic risk factors, through methylation pathways, and NOS3 gene variations for cardiovascular health in various populations to prevent IHD.en
dc.subjectepigeneticsen
dc.subjectheart-healthen
dc.subjectmeta-analysesen
dc.date.available2014-11-17T13:46:52Z-
dc.date.issued2014-11-17-
dc.date.issued2014-11-17en
dc.date.accessioned2014-11-17T13:46:52Z-
dc.conference.date2014en
dc.conference.name25th International Nursing Research Congressen
dc.conference.hostSigma Theta Tau International, the Honor Society of Nursingen
dc.conference.locationHong Kongen
dc.descriptionInternational Nursing Research Congress, 2014 Theme: Engaging Colleagues: Improving Global Health Outcomes. Held at the Hong Kong Convention and Exhibition Centre, Wanchai, Hong Kongen
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