Epigenetic Risk Factors in Women With Breast Cancer: A Family Case-Control Study

2.50
Hdl Handle:
http://hdl.handle.net/10755/335257
Category:
Full-text
Type:
Presentation
Title:
Epigenetic Risk Factors in Women With Breast Cancer: A Family Case-Control Study
Author(s):
Gonzales, Mildred C.; Shiao, Shyang-Yun Pamela K.
Lead Author STTI Affiliation:
Iota Sigma
Author Details:
Mildred C. Gonzales, RN, MSN, mgonzales10@apu.edu; Shyang-Yun Pamela K. Shiao, PhD, RN, FAAN
Abstract:
Session presented on Sunday, July 27, 2014: Purpose: The purpose is to disseminate the current scientific evidence, including meta-analyses and a pilot prospective family-based case-control study on genome health on epigenetic risk factors for breast cancer. Breast cancer is the most common malignancy and the second leading cause of cancer death among women worldwide. Methylenetetrahydrofolate reductase (MTHFR) is critical for methylation pathways for deoxyribonucleic acid (DNA) repair and normal cellular development. Methylation pathways are affected by health behaviors such as folate intake, alcohol consumption, and tobacco smoking. Methods: Meta-analyses and a prospective pilot study on the associations of MTHFR gene variations, and health behaviors with breast cancer. Results: Preliminary meta-analyses results included 55 studies for a total of 22,077 breast cancer cases and 25,419 controls including 27 studies with Whites, 21 studies with Asians, and 7 studies with mixed Euramericans. From the selected studies with MTHFR gene counts, there were 12 studies with folate intake levels for 8,032 cases and 10,482 controls; 5 studies with alcohol consumption for 3,068 cases and 5,157 controls; and 5 studies with tobacco smoking status for 909 cases and 1,233 controls. MTHFR C677T was associated with increased risk of breast cancer (P < 0.005). The results also suggested that low folate intake, heavy alcohol consumption, and tobacco smoking contributed to increased risks for breast cancer. Preliminary results of the prospective pilot study conducted in southern California will be presented. Conclusion: The results of this study can be translated into individual differences in gene variations and personalized behavioral interventions for cancer prevention. In addition, it has implications for the role of the nurses as advocates for their clients through knowledge interface from epigenetic advances to efficient health promotion in the clinical and community settings.
Keywords:
MTHFR; Health behaviors; Breast cancer
Repository Posting Date:
17-Nov-2014
Date of Publication:
17-Nov-2014 ; 17-Nov-2014
Other Identifiers:
INRC14PST247
Conference Date:
2014
Conference Name:
25th International Nursing Research Congress
Conference Host:
Sigma Theta Tau International, the Honor Society of Nursing
Conference Location:
Hong Kong
Description:
International Nursing Research Congress, 2014 Theme: Engaging Colleagues: Improving Global Health Outcomes. Held at the Hong Kong Convention and Exhibition Centre, Wanchai, Hong Kong

Full metadata record

DC FieldValue Language
dc.language.isoen_USen_GB
dc.language.isoenen
dc.type.categoryFull-texten
dc.typePresentationen
dc.titleEpigenetic Risk Factors in Women With Breast Cancer: A Family Case-Control Studyen
dc.contributor.authorGonzales, Mildred C.en
dc.contributor.authorShiao, Shyang-Yun Pamela K.en
dc.contributor.departmentIota Sigmaen
dc.author.detailsMildred C. Gonzales, RN, MSN, mgonzales10@apu.edu; Shyang-Yun Pamela K. Shiao, PhD, RN, FAANen
dc.identifier.urihttp://hdl.handle.net/10755/335257-
dc.description.abstractSession presented on Sunday, July 27, 2014: Purpose: The purpose is to disseminate the current scientific evidence, including meta-analyses and a pilot prospective family-based case-control study on genome health on epigenetic risk factors for breast cancer. Breast cancer is the most common malignancy and the second leading cause of cancer death among women worldwide. Methylenetetrahydrofolate reductase (MTHFR) is critical for methylation pathways for deoxyribonucleic acid (DNA) repair and normal cellular development. Methylation pathways are affected by health behaviors such as folate intake, alcohol consumption, and tobacco smoking. Methods: Meta-analyses and a prospective pilot study on the associations of MTHFR gene variations, and health behaviors with breast cancer. Results: Preliminary meta-analyses results included 55 studies for a total of 22,077 breast cancer cases and 25,419 controls including 27 studies with Whites, 21 studies with Asians, and 7 studies with mixed Euramericans. From the selected studies with MTHFR gene counts, there were 12 studies with folate intake levels for 8,032 cases and 10,482 controls; 5 studies with alcohol consumption for 3,068 cases and 5,157 controls; and 5 studies with tobacco smoking status for 909 cases and 1,233 controls. MTHFR C677T was associated with increased risk of breast cancer (P < 0.005). The results also suggested that low folate intake, heavy alcohol consumption, and tobacco smoking contributed to increased risks for breast cancer. Preliminary results of the prospective pilot study conducted in southern California will be presented. Conclusion: The results of this study can be translated into individual differences in gene variations and personalized behavioral interventions for cancer prevention. In addition, it has implications for the role of the nurses as advocates for their clients through knowledge interface from epigenetic advances to efficient health promotion in the clinical and community settings.en
dc.subjectMTHFRen
dc.subjectHealth behaviorsen
dc.subjectBreast canceren
dc.date.available2014-11-17T13:48:08Z-
dc.date.issued2014-11-17-
dc.date.issued2014-11-17en
dc.date.accessioned2014-11-17T13:48:08Z-
dc.conference.date2014en
dc.conference.name25th International Nursing Research Congressen
dc.conference.hostSigma Theta Tau International, the Honor Society of Nursingen
dc.conference.locationHong Kongen
dc.descriptionInternational Nursing Research Congress, 2014 Theme: Engaging Colleagues: Improving Global Health Outcomes. Held at the Hong Kong Convention and Exhibition Centre, Wanchai, Hong Kongen
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