Meta-Analyses of Epigenetics Risk Factors for Prevention of Hypertension: Angiotensinogen Human Gene Variations Across Different Race-Ethnicity Groups

2.50
Hdl Handle:
http://hdl.handle.net/10755/335280
Category:
Full-text
Type:
Presentation
Title:
Meta-Analyses of Epigenetics Risk Factors for Prevention of Hypertension: Angiotensinogen Human Gene Variations Across Different Race-Ethnicity Groups
Author(s):
Huang, Guey-Shiun; Babi, Kidest; Shiao, Shyang-Yun Pamela K.
Lead Author STTI Affiliation:
Non-member
Author Details:
Guey-Shiun Huang, PhD, RN., gueysh@ntu.edu.tw; Kidest Babi, MSN, NP; S. Pamela Shiao, PhD, RN, FAAN
Abstract:
Session presented on Sunday, July 27, 2014: Background: Hypertension is a major risk factor for heart diseases, stroke, and kidney diseases. Previous research suggests an association between Angiotensinogen (AGT) single nucleotide polymorphisms M235T variations and hypertension. Life style risk factors were associated with increased risk for hypertension. No meta-analysis concluded the association for AGT M235T with hypertension for different population groups. Purpose: The purpose of this study was to identify the association of AGT M235T gene variations and hypertension for various race-ethnicity groups and the associated risk factors for the prevention of hypertension. Method/Results: Preliminary analyses included 7607 cases and 9673 controls associating AGT M235T with hypertension from 30 case-control studies published within the last 18 years. The gene mutation variations (MT and TT subtypes) in Asians (70.8-100%) were higher than Caucasians (62.0-79.0%) in the world, for control and case groups. For validation, pollution indicators were checked and shown worse in Asia than other countries in recent years. For lifestyle related meta-analyses, smoking (11 studies, 2155 cases, 3518 controls, RR=1.14, 95% Confidence Interval =0.93-1.40), alcohol intake (5 studies, 1076 cases, 2280 controls, RR=0.82, 95% CI=0.60-1.13), and physical inactivity (3 studies, 470 cases, 2021 controls, RR=0.97, 95% CI=0.86-1.09) were pooled for meta-analyses. For association of AGT235 gene variations, genotype MM (16.9% cases, 19.1% controls) was protective against hypertension for all populations combined (RR=0.83, 95% CI=0.73-0.94, p=0.0026). Conclusion: Future research is needed to investigate the interactions between epigenetic risk factors and AGT gene variations for the population heath across the world in the prevention of hypertension.
Keywords:
meta-analysis; hypertension; angiotensinogen gene variations
Repository Posting Date:
17-Nov-2014
Date of Publication:
17-Nov-2014 ; 17-Nov-2014
Other Identifiers:
INRC14PST214
Conference Date:
2014
Conference Name:
25th International Nursing Research Congress
Conference Host:
Sigma Theta Tau International, the Honor Society of Nursing
Conference Location:
Hong Kong
Description:
International Nursing Research Congress, 2014 Theme: Engaging Colleagues: Improving Global Health Outcomes. Held at the Hong Kong Convention and Exhibition Centre, Wanchai, Hong Kong

Full metadata record

DC FieldValue Language
dc.language.isoen_USen_GB
dc.language.isoenen
dc.type.categoryFull-texten
dc.typePresentationen
dc.titleMeta-Analyses of Epigenetics Risk Factors for Prevention of Hypertension: Angiotensinogen Human Gene Variations Across Different Race-Ethnicity Groupsen
dc.contributor.authorHuang, Guey-Shiunen
dc.contributor.authorBabi, Kidesten
dc.contributor.authorShiao, Shyang-Yun Pamela K.en
dc.contributor.departmentNon-memberen
dc.author.detailsGuey-Shiun Huang, PhD, RN., gueysh@ntu.edu.tw; Kidest Babi, MSN, NP; S. Pamela Shiao, PhD, RN, FAANen
dc.identifier.urihttp://hdl.handle.net/10755/335280-
dc.description.abstractSession presented on Sunday, July 27, 2014: Background: Hypertension is a major risk factor for heart diseases, stroke, and kidney diseases. Previous research suggests an association between Angiotensinogen (AGT) single nucleotide polymorphisms M235T variations and hypertension. Life style risk factors were associated with increased risk for hypertension. No meta-analysis concluded the association for AGT M235T with hypertension for different population groups. Purpose: The purpose of this study was to identify the association of AGT M235T gene variations and hypertension for various race-ethnicity groups and the associated risk factors for the prevention of hypertension. Method/Results: Preliminary analyses included 7607 cases and 9673 controls associating AGT M235T with hypertension from 30 case-control studies published within the last 18 years. The gene mutation variations (MT and TT subtypes) in Asians (70.8-100%) were higher than Caucasians (62.0-79.0%) in the world, for control and case groups. For validation, pollution indicators were checked and shown worse in Asia than other countries in recent years. For lifestyle related meta-analyses, smoking (11 studies, 2155 cases, 3518 controls, RR=1.14, 95% Confidence Interval =0.93-1.40), alcohol intake (5 studies, 1076 cases, 2280 controls, RR=0.82, 95% CI=0.60-1.13), and physical inactivity (3 studies, 470 cases, 2021 controls, RR=0.97, 95% CI=0.86-1.09) were pooled for meta-analyses. For association of AGT235 gene variations, genotype MM (16.9% cases, 19.1% controls) was protective against hypertension for all populations combined (RR=0.83, 95% CI=0.73-0.94, p=0.0026). Conclusion: Future research is needed to investigate the interactions between epigenetic risk factors and AGT gene variations for the population heath across the world in the prevention of hypertension.en
dc.subjectmeta-analysisen
dc.subjecthypertensionen
dc.subjectangiotensinogen gene variationsen
dc.date.available2014-11-17T13:48:43Z-
dc.date.issued2014-11-17-
dc.date.issued2014-11-17en
dc.date.accessioned2014-11-17T13:48:43Z-
dc.conference.date2014en
dc.conference.name25th International Nursing Research Congressen
dc.conference.hostSigma Theta Tau International, the Honor Society of Nursingen
dc.conference.locationHong Kongen
dc.descriptionInternational Nursing Research Congress, 2014 Theme: Engaging Colleagues: Improving Global Health Outcomes. Held at the Hong Kong Convention and Exhibition Centre, Wanchai, Hong Kongen
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