Exploration of the Role of Gastroesophageal Reflux Disease in Chronic Obstructive Pulmonary Disease Patients: A Nationwide Population-Based Cohort Study

2.50
Hdl Handle:
http://hdl.handle.net/10755/335356
Category:
Full-text
Type:
Presentation
Title:
Exploration of the Role of Gastroesophageal Reflux Disease in Chronic Obstructive Pulmonary Disease Patients: A Nationwide Population-Based Cohort Study
Author(s):
Lin, Yu-Huei; Jeng, Chii
Lead Author STTI Affiliation:
Non-member
Author Details:
Yu-Huei Lin, MS, grace.yuhuei@gmail.com; Chii Jeng, PhD
Abstract:
Session presented on Friday, July 25, 2014: Purpose: To investigate whether GERD is associated with an increased risk of severe acute exacerbation of COPD (AECOPD) by analyzing a nationwide health care database. Methods: This study employed a population-based retrospective cohort design. We conducted propensity score method with 1:2 matching. In this study we analyzed 1,976 COPD subjects with GERD and 3,943 COPD subjects as a comparison group. We individually tracked each subject in this study for 12 months and identified those subjects who experienced episodes of severe AECOPD required hospitalization or emergency department visit. The cumulative incidence of AECOPD was estimated using the Kaplan-Meier method to analyze the difference between two groups. Hazard ratios (HR) were calculated using Cox proportional hazards regression analysis. Results: The incidence of severe AECOPD was 3.40 and 2.34 per 1,000 person-months in individuals with and without GERD, respectively (P=0.0137). Following adjustment for sex, age, ischemic heart disease, heart failure, atrial fibrillation, hypertension, osteoporosis, anxiety, diabetes mellitus, angina, stroke, anemia, dementia, occupational category, monthly insurance premium, Cox regression analysis revealed that GERD was associated with severe AECOPD (HR=1.45, 95% CI=1.07 ~ 1.95). Conclusion: This study demonstrated that GERD is an independent risk factor for severe AECOPD. Caution should be exercised in COPD patients when assessing GERD symptoms in clinical practice.
Keywords:
exacerbation; Chronic obstructive pulmonary disease; gastroesophageal reflux disease
Repository Posting Date:
17-Nov-2014
Date of Publication:
17-Nov-2014 ; 17-Nov-2014
Other Identifiers:
INRC14PST69
Conference Date:
2014
Conference Name:
25th International Nursing Research Congress
Conference Host:
Sigma Theta Tau International, the Honor Society of Nursing
Conference Location:
Hong Kong
Description:
International Nursing Research Congress, 2014 Theme: Engaging Colleagues: Improving Global Health Outcomes. Held at the Hong Kong Convention and Exhibition Centre, Wanchai, Hong Kong

Full metadata record

DC FieldValue Language
dc.language.isoen_USen_GB
dc.language.isoenen
dc.type.categoryFull-texten
dc.typePresentationen
dc.titleExploration of the Role of Gastroesophageal Reflux Disease in Chronic Obstructive Pulmonary Disease Patients: A Nationwide Population-Based Cohort Studyen
dc.contributor.authorLin, Yu-Hueien
dc.contributor.authorJeng, Chiien
dc.contributor.departmentNon-memberen
dc.author.detailsYu-Huei Lin, MS, grace.yuhuei@gmail.com; Chii Jeng, PhDen
dc.identifier.urihttp://hdl.handle.net/10755/335356-
dc.description.abstractSession presented on Friday, July 25, 2014: Purpose: To investigate whether GERD is associated with an increased risk of severe acute exacerbation of COPD (AECOPD) by analyzing a nationwide health care database. Methods: This study employed a population-based retrospective cohort design. We conducted propensity score method with 1:2 matching. In this study we analyzed 1,976 COPD subjects with GERD and 3,943 COPD subjects as a comparison group. We individually tracked each subject in this study for 12 months and identified those subjects who experienced episodes of severe AECOPD required hospitalization or emergency department visit. The cumulative incidence of AECOPD was estimated using the Kaplan-Meier method to analyze the difference between two groups. Hazard ratios (HR) were calculated using Cox proportional hazards regression analysis. Results: The incidence of severe AECOPD was 3.40 and 2.34 per 1,000 person-months in individuals with and without GERD, respectively (P=0.0137). Following adjustment for sex, age, ischemic heart disease, heart failure, atrial fibrillation, hypertension, osteoporosis, anxiety, diabetes mellitus, angina, stroke, anemia, dementia, occupational category, monthly insurance premium, Cox regression analysis revealed that GERD was associated with severe AECOPD (HR=1.45, 95% CI=1.07 ~ 1.95). Conclusion: This study demonstrated that GERD is an independent risk factor for severe AECOPD. Caution should be exercised in COPD patients when assessing GERD symptoms in clinical practice.en
dc.subjectexacerbationen
dc.subjectChronic obstructive pulmonary diseaseen
dc.subjectgastroesophageal reflux diseaseen
dc.date.available2014-11-17T13:50:28Z-
dc.date.issued2014-11-17-
dc.date.issued2014-11-17en
dc.date.accessioned2014-11-17T13:50:28Z-
dc.conference.date2014en
dc.conference.name25th International Nursing Research Congressen
dc.conference.hostSigma Theta Tau International, the Honor Society of Nursingen
dc.conference.locationHong Kongen
dc.descriptionInternational Nursing Research Congress, 2014 Theme: Engaging Colleagues: Improving Global Health Outcomes. Held at the Hong Kong Convention and Exhibition Centre, Wanchai, Hong Kongen
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