Meta-Analyses of Epigenetics Risk Factors for Cardiovascular Health: APOA5 Human Gene Variations Across Different Race-Ethnicity Groups

2.50
Hdl Handle:
http://hdl.handle.net/10755/335357
Category:
Full-text
Type:
Presentation
Title:
Meta-Analyses of Epigenetics Risk Factors for Cardiovascular Health: APOA5 Human Gene Variations Across Different Race-Ethnicity Groups
Other Titles:
Symposium: Meta-Analyses of Human Genome Studies: Epigenetic Risk Factors and Population Health Issues in the World
Author(s):
Lin, Yen-Chiun; Nunez, Veronica; Shiao, Shyang-Yun Pamela K.
Lead Author STTI Affiliation:
Iota Sigma
Author Details:
Yen-Chiun Lin, PhD, RN, yenlin@ntu.edu.tw; Veronica Nunez, MSN, FNP; Shyang-Yun Pamela K. Shiao, PhD, RN, FAAN
Abstract:
Session presented on Monday, July 28, 2014: Purpose: The purpose of this presentation is to disseminate current evidence on population genome health, through the meta-analyses of epigenetic risk factors, for cardiovascular (CV) health. CV Disease (CVD) continues to be the leading cause of death worldwide. Studies have associated Apolipoprotein A5 (APOA5, 1131T>C, rs662799) gene polymorphism with plasma triglyceride levels for CVD. Life style risk factors such as smoking, alcohol intake, and physical inactivity were associated with increased risks for CVD. Methods: Literature searches, quality scores, and inter-rater evaluation on data coding were completed to ensure data accuracy for pooled meta-analyses. Results: Preliminary analyses included 11,340 CVD cases and 18,758 controls from 37 studies. The gene mutation variations (TC and CC subtypes) in Asian populations were higher (53.1-42.4%) than Caucasian populations (21.4-10.2%) across the world, for control and case groups. For validation, pollution indicators were checked and shown worse in Asia than other countries. For lifestyle related meta-analyses, smoking was associated with an increased risk of CVD (18 studies, 5,035 cases, 9,140 controls, RR=1.70, 95% Confidence Interval = 1.39-2.08, p < 0.0001). However, alcohol intake (5 studies, 1,646 cases, 3094 controls, RR=1.42, 0.86-2.34) and physical inactivity (4 studies, 466 cases, 1,005 controls, RR=0.91, 0.74-1.13) were not significant for pooled meta-analyses. Conclusion: For association of APOA5 gene variations, genotype TT (61.1% cases, 69.9% controls) was protective against CVD for all populations combined (RR = 0.78, 0.74-0.83, p < 0.0001). APOA5 is a key gene for triglyceride metabolism to reduce inflammation for epigenetics in the methylation pathways. Future studies are needed to examine epigenetic factors for population health associated with APOA5 gene variations in the prevention of CVD.
Keywords:
cardiovascular-health; meta-analyses; epigenetics
Repository Posting Date:
17-Nov-2014
Date of Publication:
17-Nov-2014 ; 17-Nov-2014
Other Identifiers:
INRC14M11
Conference Date:
2014
Conference Name:
25th International Nursing Research Congress
Conference Host:
Sigma Theta Tau International, the Honor Society of Nursing
Conference Location:
Hong Kong
Description:
International Nursing Research Congress, 2014 Theme: Engaging Colleagues: Improving Global Health Outcomes. Held at the Hong Kong Convention and Exhibition Centre, Wanchai, Hong Kong

Full metadata record

DC FieldValue Language
dc.language.isoen_USen_GB
dc.language.isoenen
dc.type.categoryFull-texten
dc.typePresentationen
dc.titleMeta-Analyses of Epigenetics Risk Factors for Cardiovascular Health: APOA5 Human Gene Variations Across Different Race-Ethnicity Groupsen
dc.title.alternativeSymposium: Meta-Analyses of Human Genome Studies: Epigenetic Risk Factors and Population Health Issues in the Worlden
dc.contributor.authorLin, Yen-Chiunen
dc.contributor.authorNunez, Veronicaen
dc.contributor.authorShiao, Shyang-Yun Pamela K.en
dc.contributor.departmentIota Sigmaen
dc.author.detailsYen-Chiun Lin, PhD, RN, yenlin@ntu.edu.tw; Veronica Nunez, MSN, FNP; Shyang-Yun Pamela K. Shiao, PhD, RN, FAANen
dc.identifier.urihttp://hdl.handle.net/10755/335357-
dc.description.abstractSession presented on Monday, July 28, 2014: Purpose: The purpose of this presentation is to disseminate current evidence on population genome health, through the meta-analyses of epigenetic risk factors, for cardiovascular (CV) health. CV Disease (CVD) continues to be the leading cause of death worldwide. Studies have associated Apolipoprotein A5 (APOA5, 1131T>C, rs662799) gene polymorphism with plasma triglyceride levels for CVD. Life style risk factors such as smoking, alcohol intake, and physical inactivity were associated with increased risks for CVD. Methods: Literature searches, quality scores, and inter-rater evaluation on data coding were completed to ensure data accuracy for pooled meta-analyses. Results: Preliminary analyses included 11,340 CVD cases and 18,758 controls from 37 studies. The gene mutation variations (TC and CC subtypes) in Asian populations were higher (53.1-42.4%) than Caucasian populations (21.4-10.2%) across the world, for control and case groups. For validation, pollution indicators were checked and shown worse in Asia than other countries. For lifestyle related meta-analyses, smoking was associated with an increased risk of CVD (18 studies, 5,035 cases, 9,140 controls, RR=1.70, 95% Confidence Interval = 1.39-2.08, p < 0.0001). However, alcohol intake (5 studies, 1,646 cases, 3094 controls, RR=1.42, 0.86-2.34) and physical inactivity (4 studies, 466 cases, 1,005 controls, RR=0.91, 0.74-1.13) were not significant for pooled meta-analyses. Conclusion: For association of APOA5 gene variations, genotype TT (61.1% cases, 69.9% controls) was protective against CVD for all populations combined (RR = 0.78, 0.74-0.83, p < 0.0001). APOA5 is a key gene for triglyceride metabolism to reduce inflammation for epigenetics in the methylation pathways. Future studies are needed to examine epigenetic factors for population health associated with APOA5 gene variations in the prevention of CVD.en
dc.subjectcardiovascular-healthen
dc.subjectmeta-analysesen
dc.subjectepigeneticsen
dc.date.available2014-11-17T13:50:30Z-
dc.date.issued2014-11-17-
dc.date.issued2014-11-17en
dc.date.accessioned2014-11-17T13:50:30Z-
dc.conference.date2014en
dc.conference.name25th International Nursing Research Congressen
dc.conference.hostSigma Theta Tau International, the Honor Society of Nursingen
dc.conference.locationHong Kongen
dc.descriptionInternational Nursing Research Congress, 2014 Theme: Engaging Colleagues: Improving Global Health Outcomes. Held at the Hong Kong Convention and Exhibition Centre, Wanchai, Hong Kongen
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