Meta-Analyses of Epigenetics Risk Factors for Lung Cancer Prevention: MPO and GSTM1 Human Gene Variations Across Different Race-Ethnicity Groups

2.50
Hdl Handle:
http://hdl.handle.net/10755/335496
Category:
Full-text
Type:
Presentation
Title:
Meta-Analyses of Epigenetics Risk Factors for Lung Cancer Prevention: MPO and GSTM1 Human Gene Variations Across Different Race-Ethnicity Groups
Author(s):
Yu, Po-Jui; Shiao, Shyang-Yun Pamela K.; Suarez, Maria
Lead Author STTI Affiliation:
Lambda Beta at Large
Author Details:
Po-Jui Yu, MSN, RN, pojuiyu@ntu.edu.tw; Shyang-Yun Pamela K. Shiao, PhD, RN, FAAN; Maria Suarez, MSN, RN
Abstract:
Session presented on Monday, July 28, 2014: Purpose: The purpose of this presentation is to disseminate current evidence on population genome health, through meta-analyses of epigenetic risk factors, for lung cancer (LC) prevention. LC is one of the most common cancers worldwide and has the highest mortality rate among all cancers. Glutathione S-transferase that belongs to the mu class (GSTM1) and myeloperoxidase (MPO) gene polymorphisms have been cumulating in the literature, associating epigenetics factors and LC. Methods: Literature searches, quality scores for the studies, and inter-rater evaluation on data coding was completed to ensure data accuracy for pooled meta-analyses. Results: Preliminary analyses included 31,146 LC cases and 38,736 controls from 122 studies. The MPO gene mutations (GA and AA subtypes) in Asians were lower (16.7-33.3%) than Caucasians (31.8-49.1%) across the world, for control and case groups. However, the GSTM1 gene mutation variation (null subtype) was highest in Italians (87.5%) than other populations. Pollution indicators were checked and shown worse in Asia than other countries. For lifestyle related meta-analyses, smoking was associated with an increased risk of LC (98 studies, 28,831 cases, 35,069 controls, RR=1.40, p < 0.0001). Low vegetable intakes were associated with increased LC risk (RR = 1.26, P < 0.05) in 7 studies. No second hand smoking (6 studies) and limiting indoor pollution (3 studies) were protective for LC (RR=0.73 and 0.77, both P<0.05). Conclusion: For association of GSTM1 gene variations, genotype present (44.3% cases, 47.9% controls) was protective against LC for all populations combined in the world (RR = 0.94, p < 0.0001). Future studies are needed to examine epigenetic factors for population health associated with MPO and GSTM1 gene variations in the prevention of LC.
Keywords:
meta-analyses; epigenetics; lung-cancer
Repository Posting Date:
17-Nov-2014
Date of Publication:
11 ; 11
Conference Date:
2014
Conference Name:
25th International Nursing Research Congress
Conference Host:
Sigma Theta Tau International, the Honor Society of Nursing
Conference Location:
Hong Kong
Description:
International Nursing Research Congress, 2014 Theme: Engaging Colleagues: Improving Global Health Outcomes. Held at the Hong Kong Convention and Exhibition Centre, Wanchai, Hong Kong

Full metadata record

DC FieldValue Language
dc.language.isoen_USen_GB
dc.language.isoenen
dc.type.categoryFull-texten
dc.typePresentationen
dc.titleMeta-Analyses of Epigenetics Risk Factors for Lung Cancer Prevention: MPO and GSTM1 Human Gene Variations Across Different Race-Ethnicity Groupsen
dc.contributor.authorYu, Po-Juien
dc.contributor.authorShiao, Shyang-Yun Pamela K.en
dc.contributor.authorSuarez, Mariaen
dc.contributor.departmentLambda Beta at Largeen
dc.author.detailsPo-Jui Yu, MSN, RN, pojuiyu@ntu.edu.tw; Shyang-Yun Pamela K. Shiao, PhD, RN, FAAN; Maria Suarez, MSN, RNen
dc.identifier.urihttp://hdl.handle.net/10755/335496-
dc.description.abstractSession presented on Monday, July 28, 2014: Purpose: The purpose of this presentation is to disseminate current evidence on population genome health, through meta-analyses of epigenetic risk factors, for lung cancer (LC) prevention. LC is one of the most common cancers worldwide and has the highest mortality rate among all cancers. Glutathione S-transferase that belongs to the mu class (GSTM1) and myeloperoxidase (MPO) gene polymorphisms have been cumulating in the literature, associating epigenetics factors and LC. Methods: Literature searches, quality scores for the studies, and inter-rater evaluation on data coding was completed to ensure data accuracy for pooled meta-analyses. Results: Preliminary analyses included 31,146 LC cases and 38,736 controls from 122 studies. The MPO gene mutations (GA and AA subtypes) in Asians were lower (16.7-33.3%) than Caucasians (31.8-49.1%) across the world, for control and case groups. However, the GSTM1 gene mutation variation (null subtype) was highest in Italians (87.5%) than other populations. Pollution indicators were checked and shown worse in Asia than other countries. For lifestyle related meta-analyses, smoking was associated with an increased risk of LC (98 studies, 28,831 cases, 35,069 controls, RR=1.40, p < 0.0001). Low vegetable intakes were associated with increased LC risk (RR = 1.26, P < 0.05) in 7 studies. No second hand smoking (6 studies) and limiting indoor pollution (3 studies) were protective for LC (RR=0.73 and 0.77, both P<0.05). Conclusion: For association of GSTM1 gene variations, genotype present (44.3% cases, 47.9% controls) was protective against LC for all populations combined in the world (RR = 0.94, p < 0.0001). Future studies are needed to examine epigenetic factors for population health associated with MPO and GSTM1 gene variations in the prevention of LC.en
dc.subjectmeta-analysesen
dc.subjectepigeneticsen
dc.subjectlung-canceren
dc.date.available2014-11-17T13:53:52Z-
dc.date.issued11/17/2014-
dc.date.issued11/17/2014en
dc.date.accessioned2014-11-17T13:53:52Z-
dc.conference.date2014en
dc.conference.name25th International Nursing Research Congressen
dc.conference.hostSigma Theta Tau International, the Honor Society of Nursingen
dc.conference.locationHong Kongen
dc.descriptionInternational Nursing Research Congress, 2014 Theme: Engaging Colleagues: Improving Global Health Outcomes. Held at the Hong Kong Convention and Exhibition Centre, Wanchai, Hong Kongen
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