The Association of Inflammation With Obesity and Depressive Symptoms Among People With Multiple Cardiovascular Disease Risk Factors

2.50
Hdl Handle:
http://hdl.handle.net/10755/335562
Category:
Abstract
Type:
Presentation
Title:
The Association of Inflammation With Obesity and Depressive Symptoms Among People With Multiple Cardiovascular Disease Risk Factors
Author(s):
Lee, Kyoung Suk; Lennie, Terry A.; Casey, Baretta R.; Novak, John M.; Ailey, Alison L. B.; Moser, Debra K.; Mudd-Martin, Gia
Lead Author STTI Affiliation:
Non-member
Author Details:
Kyoung Suk Lee, PhD, RN, MPH, kslee4@wisc.edu; Terry A. Lennie, PhD, RN, FAHA, FAAN; Baretta R. Casey, MD, MPH, FAAFP; John M. Novak, BDS, LDS, MS, PhD; Alison L. B. Ailey, MD; Debra K. Moser, DNSc, RN, FAAN; Gia Mudd-Martin, PhD, MPH, RN
Abstract:
Session presented on Sunday, July 27, 2014: Purpose: Obesity and depression are associated with inflammation. Inflammation is a biological mechanism underlying cardiovascular disease (CVD). Obese people with depression may be at a greater risk for CVD due to increased inflammation, compared to obese people without depression or non-obese people with depression. However, potential combined effects of obesity and depression on inflammation have not been investigated. The purpose of this study was to examine combined effects of obesity and depression on the inflammatory marker, high sensitivity C-reactive protein (hs-CRP), in people with multiple CVD risk factors.  Methods: A total of 859 people (52 yrs, 75% female) provided blood for serum hs-CRP and had height and weight measured for body mass index (BMI=kg/m2). The Patient Health Questionniare-9 (PHQ-9) was used to measure depressive symptoms. Hierarchical regression was used to examine whether the interaction of BMI and depressive symptoms (BMI*PHQ-9) predicted hs-CRP levels after controlling for covariates (age, gender, HbA1C, and smoking history). In Step 1, covariates and depressive symptoms were entered, followed by BMI in Step 2. In Step3, the interaction of BMI and PHQ-9 scores (BMI*PHQ-9) was added. Results: In Step 1, PHQ-9 scores independently predicted hs-CRP levels. In Step 2, BMI, but not PHQ-9 scores, independently predicted hs-CRP levels. In Step 3, there was no BMI* PHQ-9 interaction; only BMI predicted hs-CRP levels (Table). Conclusions: In the company of obesity, depressive symptoms do not significantly contribute to increased inflammation in people with multiple CVD risk factors. This study suggests that obesity is more strongly linked with inflammatory processes relevant to cardiovascular risk than depressive symptoms in this population.
Keywords:
depression; cardiovascular disease prevention; obesity
Repository Posting Date:
17-Nov-2014
Date of Publication:
17-Nov-2014
Conference Date:
2014
Conference Name:
25th International Nursing Research Congress
Conference Host:
Sigma Theta Tau International, the Honor Society of Nursing
Conference Location:
Hong Kong
Description:
International Nursing Research Congress, 2014 Theme: Engaging Colleagues: Improving Global Health Outcomes. Held at the Hong Kong Convention and Exhibition Centre, Wanchai, Hong Kong
Note:
This is an abstract-only submission. If the author has submitted a full-text item related to this abstract, you may find it by browsing the repository by author. If author contact information is availabe in this abstract, please feel free to contact him or her with your queries regarding this submission.

Full metadata record

DC FieldValue Language
dc.language.isoen_USen_GB
dc.type.categoryAbstracten_GB
dc.typePresentationen_GB
dc.titleThe Association of Inflammation With Obesity and Depressive Symptoms Among People With Multiple Cardiovascular Disease Risk Factorsen_GB
dc.contributor.authorLee, Kyoung Suken_GB
dc.contributor.authorLennie, Terry A.en_GB
dc.contributor.authorCasey, Baretta R.en_GB
dc.contributor.authorNovak, John M.en_GB
dc.contributor.authorAiley, Alison L. B.en_GB
dc.contributor.authorMoser, Debra K.en_GB
dc.contributor.authorMudd-Martin, Giaen_GB
dc.contributor.departmentNon-memberen_GB
dc.author.detailsKyoung Suk Lee, PhD, RN, MPH, kslee4@wisc.edu; Terry A. Lennie, PhD, RN, FAHA, FAAN; Baretta R. Casey, MD, MPH, FAAFP; John M. Novak, BDS, LDS, MS, PhD; Alison L. B. Ailey, MD; Debra K. Moser, DNSc, RN, FAAN; Gia Mudd-Martin, PhD, MPH, RNen_GB
dc.identifier.urihttp://hdl.handle.net/10755/335562-
dc.description.abstractSession presented on Sunday, July 27, 2014: Purpose: Obesity and depression are associated with inflammation. Inflammation is a biological mechanism underlying cardiovascular disease (CVD). Obese people with depression may be at a greater risk for CVD due to increased inflammation, compared to obese people without depression or non-obese people with depression. However, potential combined effects of obesity and depression on inflammation have not been investigated. The purpose of this study was to examine combined effects of obesity and depression on the inflammatory marker, high sensitivity C-reactive protein (hs-CRP), in people with multiple CVD risk factors.  Methods: A total of 859 people (52 yrs, 75% female) provided blood for serum hs-CRP and had height and weight measured for body mass index (BMI=kg/m2). The Patient Health Questionniare-9 (PHQ-9) was used to measure depressive symptoms. Hierarchical regression was used to examine whether the interaction of BMI and depressive symptoms (BMI*PHQ-9) predicted hs-CRP levels after controlling for covariates (age, gender, HbA1C, and smoking history). In Step 1, covariates and depressive symptoms were entered, followed by BMI in Step 2. In Step3, the interaction of BMI and PHQ-9 scores (BMI*PHQ-9) was added. Results: In Step 1, PHQ-9 scores independently predicted hs-CRP levels. In Step 2, BMI, but not PHQ-9 scores, independently predicted hs-CRP levels. In Step 3, there was no BMI* PHQ-9 interaction; only BMI predicted hs-CRP levels (Table). Conclusions: In the company of obesity, depressive symptoms do not significantly contribute to increased inflammation in people with multiple CVD risk factors. This study suggests that obesity is more strongly linked with inflammatory processes relevant to cardiovascular risk than depressive symptoms in this population.en_GB
dc.subjectdepressionen_GB
dc.subjectcardiovascular disease preventionen_GB
dc.subjectobesityen_GB
dc.date.available2014-11-17T13:54:58Z-
dc.date.issued2014-11-17-
dc.date.accessioned2014-11-17T13:54:58Z-
dc.conference.date2014en_GB
dc.conference.name25th International Nursing Research Congressen_GB
dc.conference.hostSigma Theta Tau International, the Honor Society of Nursingen_GB
dc.conference.locationHong Kongen_GB
dc.descriptionInternational Nursing Research Congress, 2014 Theme: Engaging Colleagues: Improving Global Health Outcomes. Held at the Hong Kong Convention and Exhibition Centre, Wanchai, Hong Kongen_GB
dc.description.noteThis is an abstract-only submission. If the author has submitted a full-text item related to this abstract, you may find it by browsing the repository by author. If author contact information is availabe in this abstract, please feel free to contact him or her with your queries regarding this submission.en_GB
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