Risk Factors of Thromboembolic Events and the Impact on Survival in Newly Diagnosed Breast Cancer Patients: An Experience From Taiwan

2.50
Hdl Handle:
http://hdl.handle.net/10755/335588
Category:
Abstract
Type:
Presentation
Title:
Risk Factors of Thromboembolic Events and the Impact on Survival in Newly Diagnosed Breast Cancer Patients: An Experience From Taiwan
Author(s):
Hsieh, Pi-Ching; Su, Hui-Fang; Lin, Kuan-Chia
Lead Author STTI Affiliation:
Lambda Beta-at-Large
Author Details:
Pi-Ching Hsieh, PhD, RN, hpc@ntunhs.edu.tw; Hui-Fang Su, RN, PhD; Kuan-Chia Lin, PhD
Abstract:
Session presented on Saturday, July 26, 2014: Purpose: Thromboembolic events (TEEs) are one of the major complications of breast cancer patients and associate with increased mortality. These events have been included as the Core Measure Set by Joint Commission International for the international hospital evaluation in 2013. However, few evidence-based data are available on the development of TEEs in breast cancer patients in Taiwan. Methods: Using the National Health Insurance Research Database between 1997- 2010 in Taiwan, we conducted a retrospective cohort study to evaluate 2-year incidence of TEEs and risk factors on 2000-2008 breast cancer cohorts. Matching based on the propensity of age and co-morbidity was used to identify the patients with and without TEEs groups. An accelerated failure time model was applied to analyze the effect of TEEs on death within 2 years after breast cancer diagnosis. Results: A total of 80598 patients with breast cancer between 2000 and 2008, the 2-year cumulative TEEs incidence was 1.78% (95% CI = 1.74-1.82), with a rate of 1.38 and 0.43 events/100 patient-years during the first and second half year, respectively. In multivariate model, significant predictors of developing TEEs within 2 years were: age (adjusted incidence rate ratio [adj. IRR] = 3.87 if ≧65 year v<45; 95% CI = 3.80-3.93), co-morbidity (adj. IRR = 1.96 if ≧3 v 0, 95% CI = 1.93-2.00), hypertension history (adj. IRR = 1.43 if yes v no, 95% CI = 1.41-1.45), breast surgery (adj. IRR = 1.47 if yes v no, 95% CI = 1.45-1.49), radiotherapy (adj. IRR = 1.29 if yes v no, 95% CI = 1.28-1.31), chemotherapy (adj. IRR = 1.40 if yes v no, 95% CI = 1.38-1.42), hormone therapy (adj. IRR = 0.92 if yes v no, 95% CI = 0.91-0.94), and type of hospital (adj. IRR = 1.13 if district v medical center 95% CI = 1.11-1.15). In AFT model analysis, after controlling the characteristics of patient, treatment, hospital, TEE was a significant predictor of decrease 2-year survival (adjusted rate ratio [adj. RR = 2.55, 95 % CI = 2.24-2.91). Conclusion: Approximate 1.78% of breast cancer patients developed TEEs within 2 years, with the highest incidence in the first 6 months after diagnosis. Age, co-morbidity, hypertension history, breast surgery, radiotherapy, chemotherapy, and type of hospital level were the significant predictors. Breast cancer patients with TEEs were associated with a higher risk of death within 2 years.
Keywords:
thromboembolic events; survival; incidence rate
Repository Posting Date:
17-Nov-2014
Date of Publication:
17-Nov-2014
Conference Date:
2014
Conference Name:
25th International Nursing Research Congress
Conference Host:
Sigma Theta Tau International, the Honor Society of Nursing
Conference Location:
Hong Kong
Description:
International Nursing Research Congress, 2014 Theme: Engaging Colleagues: Improving Global Health Outcomes. Held at the Hong Kong Convention and Exhibition Centre, Wanchai, Hong Kong
Note:
This is an abstract-only submission. If the author has submitted a full-text item related to this abstract, you may find it by browsing the repository by author. If author contact information is availabe in this abstract, please feel free to contact him or her with your queries regarding this submission.

Full metadata record

DC FieldValue Language
dc.language.isoen_USen_GB
dc.type.categoryAbstracten_GB
dc.typePresentationen_GB
dc.titleRisk Factors of Thromboembolic Events and the Impact on Survival in Newly Diagnosed Breast Cancer Patients: An Experience From Taiwanen_GB
dc.contributor.authorHsieh, Pi-Chingen_GB
dc.contributor.authorSu, Hui-Fangen_GB
dc.contributor.authorLin, Kuan-Chiaen_GB
dc.contributor.departmentLambda Beta-at-Largeen_GB
dc.author.detailsPi-Ching Hsieh, PhD, RN, hpc@ntunhs.edu.tw; Hui-Fang Su, RN, PhD; Kuan-Chia Lin, PhDen_GB
dc.identifier.urihttp://hdl.handle.net/10755/335588-
dc.description.abstractSession presented on Saturday, July 26, 2014: Purpose: Thromboembolic events (TEEs) are one of the major complications of breast cancer patients and associate with increased mortality. These events have been included as the Core Measure Set by Joint Commission International for the international hospital evaluation in 2013. However, few evidence-based data are available on the development of TEEs in breast cancer patients in Taiwan. Methods: Using the National Health Insurance Research Database between 1997- 2010 in Taiwan, we conducted a retrospective cohort study to evaluate 2-year incidence of TEEs and risk factors on 2000-2008 breast cancer cohorts. Matching based on the propensity of age and co-morbidity was used to identify the patients with and without TEEs groups. An accelerated failure time model was applied to analyze the effect of TEEs on death within 2 years after breast cancer diagnosis. Results: A total of 80598 patients with breast cancer between 2000 and 2008, the 2-year cumulative TEEs incidence was 1.78% (95% CI = 1.74-1.82), with a rate of 1.38 and 0.43 events/100 patient-years during the first and second half year, respectively. In multivariate model, significant predictors of developing TEEs within 2 years were: age (adjusted incidence rate ratio [adj. IRR] = 3.87 if ≧65 year v<45; 95% CI = 3.80-3.93), co-morbidity (adj. IRR = 1.96 if ≧3 v 0, 95% CI = 1.93-2.00), hypertension history (adj. IRR = 1.43 if yes v no, 95% CI = 1.41-1.45), breast surgery (adj. IRR = 1.47 if yes v no, 95% CI = 1.45-1.49), radiotherapy (adj. IRR = 1.29 if yes v no, 95% CI = 1.28-1.31), chemotherapy (adj. IRR = 1.40 if yes v no, 95% CI = 1.38-1.42), hormone therapy (adj. IRR = 0.92 if yes v no, 95% CI = 0.91-0.94), and type of hospital (adj. IRR = 1.13 if district v medical center 95% CI = 1.11-1.15). In AFT model analysis, after controlling the characteristics of patient, treatment, hospital, TEE was a significant predictor of decrease 2-year survival (adjusted rate ratio [adj. RR = 2.55, 95 % CI = 2.24-2.91). Conclusion: Approximate 1.78% of breast cancer patients developed TEEs within 2 years, with the highest incidence in the first 6 months after diagnosis. Age, co-morbidity, hypertension history, breast surgery, radiotherapy, chemotherapy, and type of hospital level were the significant predictors. Breast cancer patients with TEEs were associated with a higher risk of death within 2 years.en_GB
dc.subjectthromboembolic eventsen_GB
dc.subjectsurvivalen_GB
dc.subjectincidence rateen_GB
dc.date.available2014-11-17T13:55:26Z-
dc.date.issued2014-11-17-
dc.date.accessioned2014-11-17T13:55:26Z-
dc.conference.date2014en_GB
dc.conference.name25th International Nursing Research Congressen_GB
dc.conference.hostSigma Theta Tau International, the Honor Society of Nursingen_GB
dc.conference.locationHong Kongen_GB
dc.descriptionInternational Nursing Research Congress, 2014 Theme: Engaging Colleagues: Improving Global Health Outcomes. Held at the Hong Kong Convention and Exhibition Centre, Wanchai, Hong Kongen_GB
dc.description.noteThis is an abstract-only submission. If the author has submitted a full-text item related to this abstract, you may find it by browsing the repository by author. If author contact information is availabe in this abstract, please feel free to contact him or her with your queries regarding this submission.en_GB
All Items in this repository are protected by copyright, with all rights reserved, unless otherwise indicated.