Gene Mutations and Pregnancy Induced Hypertension: A Meta-Analysis

2.50
Hdl Handle:
http://hdl.handle.net/10755/602587
Category:
Full-text
Format:
Text-based Document
Type:
Poster
Title:
Gene Mutations and Pregnancy Induced Hypertension: A Meta-Analysis
Author(s):
Yang, Ya-Ling; Shiao, Shyang-Yun Pamela K.; Shiao, Shyang-Yun Pamela K.
Lead Author STTI Affiliation:
Lambda Beta-at-Large
Author Details:
Ya-Ling Yang, RN, PhD, ylyang@ntu.edu.tw; Shyang-Yun Pamela K. Shiao, PhD, RN, FAAN
Abstract:
Session presented on Monday, November 9, 2015 and Tuesday, November 10, 2015: The purpose of this study is to disseminate current evidence on population genome health and related epigenetic factors, through the meta-analyses of methylenetetrahydrofolate reductase (MTHFR) gene in pregnant women who developed hypertension (PIH). PIH including preeclampsia are the leading causes of maternal and perinatal mortalities.  Preeclampsia presents not only more severe form of PIH, but also additional dysfunctions including edema, proteinuria, headache, and impaired vision. Literatures were searched from various databases using a set of key words for the meta-analyses. Quality scores for the studies and inter-rater evaluation on data coding were completed to ensure data accuracy for pooled meta-analyses. Preliminary results included 6079 cases and 11061controls from 53 studies. MTHFR 677 homozygous (TT) mutation genotype was significantly associated with increased risk of developing PIH (RR= 1.23, p < 0.01). Subgroup analyses revealed that MTHFR 677TT subtype was a significant risk of PIH in European (RR= 1.20, p < 0.01; 2478 cases and 6175 controls in 19 studies) and in Asian (RR= 1.56, p < 0.01, 1261 cases and 2238 controls in 13 studies). For lifestyle factors, body mass index (BMI) before pregnancy (Kg/M 2) was an important predictor for the development of PIH. Normal weight (BMI < 25) was protective against the development of PIH and preeclampsia (RR = 0.75, p < 0.0001); whereas, overweight (BMI = 25-29, RR = 1.52, p < 0.0001) and obesity (BMI > 30, RR = 1.80, p < 0.0001) were associated with increased risk of developing PIH and preeclampsia (376 cases and 2294 controls in 2 studies of Caucasian women). Future studies are needed to examine epigenetic factors associated with MTHFR gene mutations in the prevention PIH. Keywords: meta-analyses, epigenetics, pregnancy induced hypertension
Keywords:
pregnancy induced hypertension; epigenetics; meta-analyses
Repository Posting Date:
21-Mar-2016
Date of Publication:
21-Mar-2016
Other Identifiers:
CONV15EB2.42
Conference Date:
2015
Conference Name:
43rd Biennial Convention
Conference Host:
Sigma Theta Tau International, the Honor Society of Nursing
Conference Location:
Las Vegas, Nevada, USA
Description:
43rd Biennial Convention 2015 Theme: Serve Locally, Transform Regionally, Lead Globally.`

Full metadata record

DC FieldValue Language
dc.language.isoen_USen
dc.type.categoryFull-texten
dc.formatText-based Documenten
dc.typePosteren
dc.titleGene Mutations and Pregnancy Induced Hypertension: A Meta-Analysisen
dc.contributor.authorYang, Ya-Lingen
dc.contributor.authorShiao, Shyang-Yun Pamela K.en
dc.contributor.authorShiao, Shyang-Yun Pamela K.en
dc.contributor.departmentLambda Beta-at-Largeen
dc.author.detailsYa-Ling Yang, RN, PhD, ylyang@ntu.edu.tw; Shyang-Yun Pamela K. Shiao, PhD, RN, FAANen
dc.identifier.urihttp://hdl.handle.net/10755/602587en
dc.description.abstractSession presented on Monday, November 9, 2015 and Tuesday, November 10, 2015: The purpose of this study is to disseminate current evidence on population genome health and related epigenetic factors, through the meta-analyses of methylenetetrahydrofolate reductase (MTHFR) gene in pregnant women who developed hypertension (PIH). PIH including preeclampsia are the leading causes of maternal and perinatal mortalities.  Preeclampsia presents not only more severe form of PIH, but also additional dysfunctions including edema, proteinuria, headache, and impaired vision. Literatures were searched from various databases using a set of key words for the meta-analyses. Quality scores for the studies and inter-rater evaluation on data coding were completed to ensure data accuracy for pooled meta-analyses. Preliminary results included 6079 cases and 11061controls from 53 studies. MTHFR 677 homozygous (TT) mutation genotype was significantly associated with increased risk of developing PIH (RR= 1.23, p < 0.01). Subgroup analyses revealed that MTHFR 677TT subtype was a significant risk of PIH in European (RR= 1.20, p < 0.01; 2478 cases and 6175 controls in 19 studies) and in Asian (RR= 1.56, p < 0.01, 1261 cases and 2238 controls in 13 studies). For lifestyle factors, body mass index (BMI) before pregnancy (Kg/M 2) was an important predictor for the development of PIH. Normal weight (BMI < 25) was protective against the development of PIH and preeclampsia (RR = 0.75, p < 0.0001); whereas, overweight (BMI = 25-29, RR = 1.52, p < 0.0001) and obesity (BMI > 30, RR = 1.80, p < 0.0001) were associated with increased risk of developing PIH and preeclampsia (376 cases and 2294 controls in 2 studies of Caucasian women). Future studies are needed to examine epigenetic factors associated with MTHFR gene mutations in the prevention PIH. Keywords: meta-analyses, epigenetics, pregnancy induced hypertensionen
dc.subjectpregnancy induced hypertensionen
dc.subjectepigeneticsen
dc.subjectmeta-analysesen
dc.date.available2016-03-21T16:32:25Zen
dc.date.issued2016-03-21en
dc.date.accessioned2016-03-21T16:32:25Zen
dc.conference.date2015en
dc.conference.name43rd Biennial Conventionen
dc.conference.hostSigma Theta Tau International, the Honor Society of Nursingen
dc.conference.locationLas Vegas, Nevada, USAen
dc.description43rd Biennial Convention 2015 Theme: Serve Locally, Transform Regionally, Lead Globally.`en
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