Integration of Evidence for Genetic Risk of Abnormal Neurodevelopment in Preterm Infants

2.50
Hdl Handle:
http://hdl.handle.net/10755/602665
Category:
Full-text
Format:
Text-based Document
Type:
Poster
Title:
Integration of Evidence for Genetic Risk of Abnormal Neurodevelopment in Preterm Infants
Author(s):
Blair, Lisa M.; Pickler, Rita H.; Anderson, Cindy M.; Pickler, Rita H.; Anderson, Cindy M.
Lead Author STTI Affiliation:
Non-member
Author Details:
Lisa M. Blair, RN, RNC-NIC, blair.365@osu.edu; Rita H. Pickler, PhD, RN, FAAN; Cindy M. Anderson, RN
Abstract:
Session presented on Saturday, November 7, 2015 and Sunday, November 8, 2015: Problem: Preterm infants are at elevated risk for a host of atypical neurodevelopmental problems, including disorders that appear later in life. A growing body of evidence supports a genetic link to risk for atypical neurodevelopment even among infants who do not have apparent genetic disease; however, no genomic risk profiles are currently used, despite the potential benefit of early intervention for those at risk. Purpose: The purpose of this integrative review was to synthesize recent evidence of genetic associations with atypical neurodevelopmental outcomes that may pose additional risk to preterm infants who do not have rare, genetic disease. Search Strategy: Electronic database searches were conducted in PubMed and CINAHL using the terms "neurodevelopment" and "genetic." Searches were limited to English-language, peer-reviewed primary research or meta-analysis reports published between July 2009 and July 2014 involving living human participants. As neurodevelopmental outcomes related to preterm birth may not appear until later in life, the search was not limited to infants, however, articles were excluded if there was no explicit genetic link with neurodevelopment or if no association was found with neurodevelopmental outcomes in novel gene targets. Results of literature search: 28 original research reports and 1 meta-analysis were included ( n = 29). Synthesis of Evidence: Articles included in the analysis used a wide range of study designs, genomic approaches, outcome measures, and methodologies; an integrative review design and PRISMA reporting guidelines were used to synthesize these diverse data. Multiple large genetic deletions and polymorphisms of 43 genes were associated with neurodevelopmental outcomes. Articles were ranked based on quality parameters, as multiple studies demonstrated methodological or reporting concerns. Implications for Practice: The creation of genetic risk profiles for complex disorders of neurodevelopment would allow screening and early intervention among infants with the added neurodevelopmental risk of prematurity. This is presently hindered by inconsistent genetic association evidence, methodological considerations, reporting issues, and lack of replication. However, several avenues of investigation offer promising targets for future research, including the candidate genes Met, NRG3, and SLC6A4 and large genetic deletions, each of which were reported to have associations to neurodevelopmental outcomes in multiple, high-quality studies.
Keywords:
Neurodevelopment; Preterm Infant; Genetic
Repository Posting Date:
21-Mar-2016
Date of Publication:
21-Mar-2016
Other Identifiers:
CONV15RS1.11
Conference Date:
2015
Conference Name:
43rd Biennial Convention
Conference Host:
Sigma Theta Tau International, the Honor Society of Nursing
Conference Location:
Las Vegas, Nevada, USA
Description:
43rd Biennial Convention 2015 Theme: Serve Locally, Transform Regionally, Lead Globally.`

Full metadata record

DC FieldValue Language
dc.language.isoen_USen
dc.type.categoryFull-texten
dc.formatText-based Documenten
dc.typePosteren
dc.titleIntegration of Evidence for Genetic Risk of Abnormal Neurodevelopment in Preterm Infantsen
dc.contributor.authorBlair, Lisa M.en
dc.contributor.authorPickler, Rita H.en
dc.contributor.authorAnderson, Cindy M.en
dc.contributor.authorPickler, Rita H.en
dc.contributor.authorAnderson, Cindy M.en
dc.contributor.departmentNon-memberen
dc.author.detailsLisa M. Blair, RN, RNC-NIC, blair.365@osu.edu; Rita H. Pickler, PhD, RN, FAAN; Cindy M. Anderson, RNen
dc.identifier.urihttp://hdl.handle.net/10755/602665en
dc.description.abstractSession presented on Saturday, November 7, 2015 and Sunday, November 8, 2015: Problem: Preterm infants are at elevated risk for a host of atypical neurodevelopmental problems, including disorders that appear later in life. A growing body of evidence supports a genetic link to risk for atypical neurodevelopment even among infants who do not have apparent genetic disease; however, no genomic risk profiles are currently used, despite the potential benefit of early intervention for those at risk. Purpose: The purpose of this integrative review was to synthesize recent evidence of genetic associations with atypical neurodevelopmental outcomes that may pose additional risk to preterm infants who do not have rare, genetic disease. Search Strategy: Electronic database searches were conducted in PubMed and CINAHL using the terms "neurodevelopment" and "genetic." Searches were limited to English-language, peer-reviewed primary research or meta-analysis reports published between July 2009 and July 2014 involving living human participants. As neurodevelopmental outcomes related to preterm birth may not appear until later in life, the search was not limited to infants, however, articles were excluded if there was no explicit genetic link with neurodevelopment or if no association was found with neurodevelopmental outcomes in novel gene targets. Results of literature search: 28 original research reports and 1 meta-analysis were included ( n = 29). Synthesis of Evidence: Articles included in the analysis used a wide range of study designs, genomic approaches, outcome measures, and methodologies; an integrative review design and PRISMA reporting guidelines were used to synthesize these diverse data. Multiple large genetic deletions and polymorphisms of 43 genes were associated with neurodevelopmental outcomes. Articles were ranked based on quality parameters, as multiple studies demonstrated methodological or reporting concerns. Implications for Practice: The creation of genetic risk profiles for complex disorders of neurodevelopment would allow screening and early intervention among infants with the added neurodevelopmental risk of prematurity. This is presently hindered by inconsistent genetic association evidence, methodological considerations, reporting issues, and lack of replication. However, several avenues of investigation offer promising targets for future research, including the candidate genes Met, NRG3, and SLC6A4 and large genetic deletions, each of which were reported to have associations to neurodevelopmental outcomes in multiple, high-quality studies.en
dc.subjectNeurodevelopmenten
dc.subjectPreterm Infanten
dc.subjectGeneticen
dc.date.available2016-03-21T16:34:04Zen
dc.date.issued2016-03-21en
dc.date.accessioned2016-03-21T16:34:04Zen
dc.conference.date2015en
dc.conference.name43rd Biennial Conventionen
dc.conference.hostSigma Theta Tau International, the Honor Society of Nursingen
dc.conference.locationLas Vegas, Nevada, USAen
dc.description43rd Biennial Convention 2015 Theme: Serve Locally, Transform Regionally, Lead Globally.`en
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