Impact of Maternal Childhood Adversity on the Psycho-Neuroendocrine-Inflammatory Profile during Pregnancy

2.50
Hdl Handle:
http://hdl.handle.net/10755/602669
Category:
Full-text
Format:
Text-based Document
Type:
Poster
Title:
Impact of Maternal Childhood Adversity on the Psycho-Neuroendocrine-Inflammatory Profile during Pregnancy
Author(s):
Kotz, Karen J.; Cooper, Dina Tell; Mathews, Herbert L.; Janusek, Linda Witek; Tell Cooper, Dina; Mathews, Herbert L.; Witek Janusek, Linda
Lead Author STTI Affiliation:
Alpha Beta
Author Details:
Karen J. Kotz, MSN, BSN, RN, NNP-BC, karenjkotz@gmail.com; Dina Tell Cooper; Herbert L. Mathews; Linda Witek Janusek, RN, FAAN
Abstract:
Session presented on Saturday, November 7, 2015 and Sunday, November 8, 2015: Background: Pregnancy is accompanied by a multitude of physical and psychological changes.  Adaptation to these changes through reduced anxiety and attenuated stress responsiveness is necessary across gestation for optimal maternal infant health.  Ample evidence demonstrates that perception of high levels of psychosocial stress and/or mood disturbance during pregnancy can disrupt neuroendocrine-inflammatory processes required for successful pregnancy outcomes. In particular, precise regulation of circulating proinflammatory cytokines across gestation is critical for the maintenance of pregnancy; lower levels during mid gestation keep the uterus in a quiescent state, whereas, near term levels of proinflammatory cytokines increase to initiate birth. Purpose: The primary aim was to examine the relationship between maternal childhood adversity and prenatal levels of stress, depression, and proinflammatory cytokines; and, secondly, to explore the relationship of these variables with neonatal birth outcomes.  Significance/Rationale: Increased proinflammatory cytokines during pregnancy are linked to maternal depressive risk and poor birth outcomes. Maternal exposure to  childhood adversity and poverty may intensify each of these, predisposing to health disparity in birth outcomes. Methods/Analysis: During their second (16-24 weeks gestation) and third trimester (28-32 weeks) of pregnancy, women (N=64), 18-39 years old, provided a blood sample to measure the proinflammatory cytokine, TNF-alpha; and completed instruments measuring childhood adversity (Child Trauma Questionnaire), perceived stress (Perceived Stress Scale), depression (Center for Epidemiologic Studies-Depression and Edinburgh Depression Scale) and social support (Social Provisions Scale). Childhood adversity assessed: emotional neglect/abuse, physical neglect/abuse and sexual abuse. Poverty was determined by current household income and number in the household per federal guidelines. Correlations among variables were evaluated and moderation analysis explored interaction effects. Results: Nearly 25% of the sample reported exposure to childhood adversity, and women with greater childhood adversity had increased perceived stress and increased depressive symptoms. Also, women reporting greater depressive symptoms had higher plasma TNF-alpha levels. Moderation analysis revealed that women exposed to childhood adversity, together with current household poverty, had higher levels of TNF-alpha. Evaluation of relationships with birth outcomes revealed that women with greater childhood adversity and higher TNF-alpha delivered lower birth weight infants.  Also, exposure to childhood adversity was associated with lower infant gestational age; however, higher levels of social support moderated (attenuated) this relationship. Conclusion:Maternal childhood adversity associates with greater psychological morbidity during pregnancy and poorer neonatal outcomes. Implications. Findings emphasize the need for prenatal psychosocial screening to include assessment of childhood adversity and the encouragement of social support to buffer negative effects of childhood adversity on birth outcomes.
Keywords:
Pregnancy; Childhood Adversity; Infant outcomes
Repository Posting Date:
21-Mar-2016
Date of Publication:
21-Mar-2016
Other Identifiers:
CONV15RS1.37
Conference Date:
2015
Conference Name:
43rd Biennial Convention
Conference Host:
Sigma Theta Tau International, the Honor Society of Nursing
Conference Location:
Las Vegas, Nevada, USA
Description:
43rd Biennial Convention 2015 Theme: Serve Locally, Transform Regionally, Lead Globally.`

Full metadata record

DC FieldValue Language
dc.language.isoen_USen
dc.type.categoryFull-texten
dc.formatText-based Documenten
dc.typePosteren
dc.titleImpact of Maternal Childhood Adversity on the Psycho-Neuroendocrine-Inflammatory Profile during Pregnancyen
dc.contributor.authorKotz, Karen J.en
dc.contributor.authorCooper, Dina Tellen
dc.contributor.authorMathews, Herbert L.en
dc.contributor.authorJanusek, Linda Witeken
dc.contributor.authorTell Cooper, Dinaen
dc.contributor.authorMathews, Herbert L.en
dc.contributor.authorWitek Janusek, Lindaen
dc.contributor.departmentAlpha Betaen
dc.author.detailsKaren J. Kotz, MSN, BSN, RN, NNP-BC, karenjkotz@gmail.com; Dina Tell Cooper; Herbert L. Mathews; Linda Witek Janusek, RN, FAANen
dc.identifier.urihttp://hdl.handle.net/10755/602669en
dc.description.abstractSession presented on Saturday, November 7, 2015 and Sunday, November 8, 2015: Background: Pregnancy is accompanied by a multitude of physical and psychological changes.  Adaptation to these changes through reduced anxiety and attenuated stress responsiveness is necessary across gestation for optimal maternal infant health.  Ample evidence demonstrates that perception of high levels of psychosocial stress and/or mood disturbance during pregnancy can disrupt neuroendocrine-inflammatory processes required for successful pregnancy outcomes. In particular, precise regulation of circulating proinflammatory cytokines across gestation is critical for the maintenance of pregnancy; lower levels during mid gestation keep the uterus in a quiescent state, whereas, near term levels of proinflammatory cytokines increase to initiate birth. Purpose: The primary aim was to examine the relationship between maternal childhood adversity and prenatal levels of stress, depression, and proinflammatory cytokines; and, secondly, to explore the relationship of these variables with neonatal birth outcomes.  Significance/Rationale: Increased proinflammatory cytokines during pregnancy are linked to maternal depressive risk and poor birth outcomes. Maternal exposure to  childhood adversity and poverty may intensify each of these, predisposing to health disparity in birth outcomes. Methods/Analysis: During their second (16-24 weeks gestation) and third trimester (28-32 weeks) of pregnancy, women (N=64), 18-39 years old, provided a blood sample to measure the proinflammatory cytokine, TNF-alpha; and completed instruments measuring childhood adversity (Child Trauma Questionnaire), perceived stress (Perceived Stress Scale), depression (Center for Epidemiologic Studies-Depression and Edinburgh Depression Scale) and social support (Social Provisions Scale). Childhood adversity assessed: emotional neglect/abuse, physical neglect/abuse and sexual abuse. Poverty was determined by current household income and number in the household per federal guidelines. Correlations among variables were evaluated and moderation analysis explored interaction effects. Results: Nearly 25% of the sample reported exposure to childhood adversity, and women with greater childhood adversity had increased perceived stress and increased depressive symptoms. Also, women reporting greater depressive symptoms had higher plasma TNF-alpha levels. Moderation analysis revealed that women exposed to childhood adversity, together with current household poverty, had higher levels of TNF-alpha. Evaluation of relationships with birth outcomes revealed that women with greater childhood adversity and higher TNF-alpha delivered lower birth weight infants.  Also, exposure to childhood adversity was associated with lower infant gestational age; however, higher levels of social support moderated (attenuated) this relationship. Conclusion:Maternal childhood adversity associates with greater psychological morbidity during pregnancy and poorer neonatal outcomes. Implications. Findings emphasize the need for prenatal psychosocial screening to include assessment of childhood adversity and the encouragement of social support to buffer negative effects of childhood adversity on birth outcomes.en
dc.subjectPregnancyen
dc.subjectChildhood Adversityen
dc.subjectInfant outcomesen
dc.date.available2016-03-21T16:34:09Zen
dc.date.issued2016-03-21en
dc.date.accessioned2016-03-21T16:34:09Zen
dc.conference.date2015en
dc.conference.name43rd Biennial Conventionen
dc.conference.hostSigma Theta Tau International, the Honor Society of Nursingen
dc.conference.locationLas Vegas, Nevada, USAen
dc.description43rd Biennial Convention 2015 Theme: Serve Locally, Transform Regionally, Lead Globally.`en
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