Meta-Analyses of Epigenetic Factors in the Prevention of Congenital Heart Defects: MTHFR C677T Human Gene Variations across Generations from Parents to Children

2.50
Hdl Handle:
http://hdl.handle.net/10755/602690
Category:
Full-text
Format:
Text-based Document
Type:
Poster
Title:
Meta-Analyses of Epigenetic Factors in the Prevention of Congenital Heart Defects: MTHFR C677T Human Gene Variations across Generations from Parents to Children
Author(s):
Yang, Hsiao-Ling; Shiao, Shyang-Yun Pamela K.; Shiao, Shyang-Yun Pamela K.
Lead Author STTI Affiliation:
Iota Sigma
Author Details:
Hsiao-Ling Yang, RN, slyang@ntu.edu.tw; Shyang-Yun Pamela K. Shiao, PhD, RN, FAAN
Abstract:
Session presented on Monday, November 9, 2015 and Tuesday, November 10, 2015: The purpose of this study is to disseminate current evidence on  Methylenetetrahydrofolate reductase (MTHFR) gene mutations in children and their parents, and related epigenetic factors in the prevention of the children’s congenital heart defects (CHD), through meta-analyses. MTHFR gene plays an important role in the methylation pathway for health and wellbeing across generations in the development of CHD. The association between the polymorphisms of MTHFR and CHD is contentious, thus we conducted meta-analyses on MTHFR gene mutations and related epigenetic factors across generations in the development of CHD. Quality scores for the studies, and inter-rater evaluation on data coding was completed to ensure data accuracy for pooled meta-analyses. Preliminary results included 4039 cases and 6849 controls from 31 studies for children, 817 cases and 836 controls from 16 studies for mothers, as well as 246 cases and 300 controls from 6 studies for fathers, of children with CHD. Based on children’s and their parents’ genotypes, MTHFR 677 TT homozygous mutation type was associated with increased risk (p < 0.05), whereas 677 CC wild genotype was protective for children from CHD (p < 0.05). Maternal folate supplementation during preconception and gestation was associated with a decreased risk of CHD (RR = 0.60, p < 0.01, 5 studies, 761 cases and 1428 controls). On the other hand, no supplementation of folate during preconception and gestation for mothers was associated with an increased risk of CHD (RR=1.26, p < 0.05). Maternal smoking was potentially associated with the development of CHD (3 studies, 799 cases and 1113 controls, RR =1.156, p = 0.053). Future studies are needed to examine epigenetic factors associated with MTHFR gene variations in the prevention of CHD across generations.
Keywords:
congenital heart defects; epigenetics; meta-analyses
Repository Posting Date:
21-Mar-2016
Date of Publication:
21-Mar-2016
Other Identifiers:
CONV15SC2.101
Conference Date:
2015
Conference Name:
43rd Biennial Convention
Conference Host:
Sigma Theta Tau International, the Honor Society of Nursing
Conference Location:
Las Vegas, Nevada, USA
Description:
43rd Biennial Convention 2015 Theme: Serve Locally, Transform Regionally, Lead Globally.`

Full metadata record

DC FieldValue Language
dc.language.isoen_USen
dc.type.categoryFull-texten
dc.formatText-based Documenten
dc.typePosteren
dc.titleMeta-Analyses of Epigenetic Factors in the Prevention of Congenital Heart Defects: MTHFR C677T Human Gene Variations across Generations from Parents to Childrenen
dc.contributor.authorYang, Hsiao-Lingen
dc.contributor.authorShiao, Shyang-Yun Pamela K.en
dc.contributor.authorShiao, Shyang-Yun Pamela K.en
dc.contributor.departmentIota Sigmaen
dc.author.detailsHsiao-Ling Yang, RN, slyang@ntu.edu.tw; Shyang-Yun Pamela K. Shiao, PhD, RN, FAANen
dc.identifier.urihttp://hdl.handle.net/10755/602690en
dc.description.abstractSession presented on Monday, November 9, 2015 and Tuesday, November 10, 2015: The purpose of this study is to disseminate current evidence on  Methylenetetrahydrofolate reductase (MTHFR) gene mutations in children and their parents, and related epigenetic factors in the prevention of the children’s congenital heart defects (CHD), through meta-analyses. MTHFR gene plays an important role in the methylation pathway for health and wellbeing across generations in the development of CHD. The association between the polymorphisms of MTHFR and CHD is contentious, thus we conducted meta-analyses on MTHFR gene mutations and related epigenetic factors across generations in the development of CHD. Quality scores for the studies, and inter-rater evaluation on data coding was completed to ensure data accuracy for pooled meta-analyses. Preliminary results included 4039 cases and 6849 controls from 31 studies for children, 817 cases and 836 controls from 16 studies for mothers, as well as 246 cases and 300 controls from 6 studies for fathers, of children with CHD. Based on children’s and their parents’ genotypes, MTHFR 677 TT homozygous mutation type was associated with increased risk (p < 0.05), whereas 677 CC wild genotype was protective for children from CHD (p < 0.05). Maternal folate supplementation during preconception and gestation was associated with a decreased risk of CHD (RR = 0.60, p < 0.01, 5 studies, 761 cases and 1428 controls). On the other hand, no supplementation of folate during preconception and gestation for mothers was associated with an increased risk of CHD (RR=1.26, p < 0.05). Maternal smoking was potentially associated with the development of CHD (3 studies, 799 cases and 1113 controls, RR =1.156, p = 0.053). Future studies are needed to examine epigenetic factors associated with MTHFR gene variations in the prevention of CHD across generations.en
dc.subjectcongenital heart defectsen
dc.subjectepigeneticsen
dc.subjectmeta-analysesen
dc.date.available2016-03-21T16:34:38Zen
dc.date.issued2016-03-21en
dc.date.accessioned2016-03-21T16:34:38Zen
dc.conference.date2015en
dc.conference.name43rd Biennial Conventionen
dc.conference.hostSigma Theta Tau International, the Honor Society of Nursingen
dc.conference.locationLas Vegas, Nevada, USAen
dc.description43rd Biennial Convention 2015 Theme: Serve Locally, Transform Regionally, Lead Globally.`en
All Items in this repository are protected by copyright, with all rights reserved, unless otherwise indicated.