Symptoms and Health-Related Quality of Life in Idiopathic and Associated Pulmonary Arterial Hypertension

2.50
Hdl Handle:
http://hdl.handle.net/10755/616539
Title:
Symptoms and Health-Related Quality of Life in Idiopathic and Associated Pulmonary Arterial Hypertension
Other Titles:
Disease Management: Barriers, Quality of Life and Outcomes
Author(s):
Matura, Lea Ann; McDonough, Annette; Carroll, Diane L.
Lead Author STTI Affiliation:
Theta Alpha
Author Details:
Lea Ann Matura, RN, lamatura@hotmail.com; Annette McDonough, RN; Diane L. Carroll, RN, FAAN
Abstract:
Session presented on Monday, July 25, 2016: Introduction: Pulmonary arterial hypertension (PAH) is a chronic illness affecting primarily young and middle age women. Elevated pulmonary pressures lead to right heart failure and premature death. Patients with PAH report multiple symptoms (e.g. dyspnea, fatigue) that can be severe and impair health-related quality of life (HRQOL). PAH etiology is varied with approximately half being idiopathic PAH. Associated PAH includes those with PAH caused by other disorders such as: connective tissue disease, congenital heart disease, portopulmonary hypertension and anorexigens. Purpose: The purpose of this study was to determine if there were differences between symptom severity and HRQOL in patients with idiopathic PAH and associated PAH. Methods: This was a secondary analysis of an existing data set of patients with PAH. The convenience sample included 191 patients with PAH (n=104 idiopathic PAH; n=87 associated PAH). Subjects completed a socio-demographic and clinical data form, the Pulmonary Arterial Hypertension Symptom Scale (PAHSS) (dyspnea on exertion, fatigue, difficulty sleeping, chest pain, dizziness, syncope, palpitations, dyspnea at rest, dyspnea lying down, awaken at night dyspneic, swelling ankles/feet, cough, hoarseness, abdominal swelling, nausea, loss of appetite and Raynaud?s phenomenon; scores range 0-10), and the Medical Outcomes Survey Short Form 36 (SF-36) (scores range 0-100). Descriptive statistics described the sample. Independent t-tests and chi square determined differences among continuous and categorical variables for the two groups. Results: Eighty two with idiopathic PAH were female and 22 male; in contrast, 80 with associated PAH were female and 7 were male (p=0.007). The mean age was 51.8 + 16.6 year for idiopathic PAH and 54.8 +13.0 for associated PAH (p=0.176).There were no significant differences between the groups on marital status, employment status, functional class, oxygen use or medications. There were no significant differences between symptom severity on the PAHSS. Dyspnea on exertion (idiopathic PAH 5.0 + 2.5; associated PAH 5.0 + 2.0, p=0.798) and fatigue (idiopathic PAH 6.3 + 2.7; associated PAH 6.1 + 2.8, p=0.671) were the most severe symptoms reported on the PAHSS. On the SF-36 subscales there were differences between General Health (idiopathic PAH 40.6 + 22.9; associated PAH 32.7 + 18.3, p=0.009) and Emotional (idiopathic PAH 69.1 + 20.5; associated PAH 75.2 + 17.2, p=0.029). Conclusions: Symptom severity is similar for patients with idiopathic and associated PAH. Those with associated PAH were experiencing worse General Health but better Emotional health than idiopathic PAH. The varied disease states in associated PAH may partially explain the worse reported General Health. This is important for clinicians to understand that there may be differences among the PAH etiologies in order to assess, treat appropriately and improve HRQOL.
Keywords:
pulmonary arterial hypertension; symptoms; health-related quality of life
Repository Posting Date:
13-Jul-2016
Date of Publication:
13-Jul-2016 ; 13-Jul-2016
Other Identifiers:
INRC16P02
Conference Date:
2016
Conference Name:
27th International Nursing Research Congress
Conference Host:
Sigma Theta Tau International, the Honor Society of Nursing
Conference Location:
Cape Town, South Africa
Description:
Theme: Leading Global Research: Advancing Practice, Advocacy, and Policy

Full metadata record

DC FieldValue Language
dc.language.isoenen
dc.titleSymptoms and Health-Related Quality of Life in Idiopathic and Associated Pulmonary Arterial Hypertensionen
dc.title.alternativeDisease Management: Barriers, Quality of Life and Outcomesen
dc.contributor.authorMatura, Lea Annen
dc.contributor.authorMcDonough, Annetteen
dc.contributor.authorCarroll, Diane L.en
dc.contributor.departmentTheta Alphaen
dc.author.detailsLea Ann Matura, RN, lamatura@hotmail.com; Annette McDonough, RN; Diane L. Carroll, RN, FAANen
dc.identifier.urihttp://hdl.handle.net/10755/616539-
dc.description.abstractSession presented on Monday, July 25, 2016: Introduction: Pulmonary arterial hypertension (PAH) is a chronic illness affecting primarily young and middle age women. Elevated pulmonary pressures lead to right heart failure and premature death. Patients with PAH report multiple symptoms (e.g. dyspnea, fatigue) that can be severe and impair health-related quality of life (HRQOL). PAH etiology is varied with approximately half being idiopathic PAH. Associated PAH includes those with PAH caused by other disorders such as: connective tissue disease, congenital heart disease, portopulmonary hypertension and anorexigens. Purpose: The purpose of this study was to determine if there were differences between symptom severity and HRQOL in patients with idiopathic PAH and associated PAH. Methods: This was a secondary analysis of an existing data set of patients with PAH. The convenience sample included 191 patients with PAH (n=104 idiopathic PAH; n=87 associated PAH). Subjects completed a socio-demographic and clinical data form, the Pulmonary Arterial Hypertension Symptom Scale (PAHSS) (dyspnea on exertion, fatigue, difficulty sleeping, chest pain, dizziness, syncope, palpitations, dyspnea at rest, dyspnea lying down, awaken at night dyspneic, swelling ankles/feet, cough, hoarseness, abdominal swelling, nausea, loss of appetite and Raynaud?s phenomenon; scores range 0-10), and the Medical Outcomes Survey Short Form 36 (SF-36) (scores range 0-100). Descriptive statistics described the sample. Independent t-tests and chi square determined differences among continuous and categorical variables for the two groups. Results: Eighty two with idiopathic PAH were female and 22 male; in contrast, 80 with associated PAH were female and 7 were male (p=0.007). The mean age was 51.8 + 16.6 year for idiopathic PAH and 54.8 +13.0 for associated PAH (p=0.176).There were no significant differences between the groups on marital status, employment status, functional class, oxygen use or medications. There were no significant differences between symptom severity on the PAHSS. Dyspnea on exertion (idiopathic PAH 5.0 + 2.5; associated PAH 5.0 + 2.0, p=0.798) and fatigue (idiopathic PAH 6.3 + 2.7; associated PAH 6.1 + 2.8, p=0.671) were the most severe symptoms reported on the PAHSS. On the SF-36 subscales there were differences between General Health (idiopathic PAH 40.6 + 22.9; associated PAH 32.7 + 18.3, p=0.009) and Emotional (idiopathic PAH 69.1 + 20.5; associated PAH 75.2 + 17.2, p=0.029). Conclusions: Symptom severity is similar for patients with idiopathic and associated PAH. Those with associated PAH were experiencing worse General Health but better Emotional health than idiopathic PAH. The varied disease states in associated PAH may partially explain the worse reported General Health. This is important for clinicians to understand that there may be differences among the PAH etiologies in order to assess, treat appropriately and improve HRQOL.en
dc.subjectpulmonary arterial hypertensionen
dc.subjectsymptomsen
dc.subjecthealth-related quality of lifeen
dc.date.available2016-07-13T11:14:57Z-
dc.date.issued2016-07-13-
dc.date.issued2016-07-13en
dc.date.accessioned2016-07-13T11:14:57Z-
dc.conference.date2016en
dc.conference.name27th International Nursing Research Congressen
dc.conference.hostSigma Theta Tau International, the Honor Society of Nursingen
dc.conference.locationCape Town, South Africaen
dc.descriptionTheme: Leading Global Research: Advancing Practice, Advocacy, and Policyen
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