Association Among Cachexia Syndrome, Symptom Distress, and Quality of Life in Pancreatic Cancer Patients

2.50
Hdl Handle:
http://hdl.handle.net/10755/621576
Category:
Full-text
Format:
Text-based Document
Type:
Poster
Level of Evidence:
N/A
Research Approach:
N/A
Title:
Association Among Cachexia Syndrome, Symptom Distress, and Quality of Life in Pancreatic Cancer Patients
Author(s):
Chou, Yun-Jen; Shun, Shiow-Ching
Lead Author STTI Affiliation:
Non-member
Author Details:
Yun-Jen Chou, MS, RN, Professional Experience: 2007-2009 Clinical nurses, Taipei Veterans General Hospital, Taipei, Taiwan. 2012-2017 Research Assistant, Department of Nursing, National Taiwan University College of Medicine, Taipei, Taiwan. 5 presentations at scientific meetings. Author Summary: Yun-Jen Chou is a doctoral student and research assistant in Nursing at the National Taiwan University. Also, she had been a clinical nurse for two years.
Abstract:

Background: Cachexia syndrome is common in pancreatic cancer patients, and it will increase the mortality rate and decrease quality of life (QoL). However, there is no study with longitudinal design to explore the relationship among cachexia syndrome, symptom distress and QoL. Therefore, this study was to explore if the cachexia syndrome pre-operation was the significant factors to predict the longitudinal QoL after operation .

 

Methods: A longitudinal design was used in this study, and the data collected at 1~2 weeks before operation (T0), 2 months (T1), 3 months (T2), and 6 months (T3) after operation. Patients who scheduled to operate were recruited from surgery clinics at a medical center in Taipei. A structured questionnaire with Fatigue Symptom Inventory, Symptom Severity Scale, and Functional Assessment of Cancer Therapy-General Scale were used to collect patients’ fatigue, symptom distress and QoL, respectively. In addition, the questionnaire included patients’ demographic and clinical characteristic. In this study, cachexia syndrome was defined as patients’ total body weight loss > 5% over the past 6 months. The generalized estimating equation (GEE) was used to examine the significant associated factors with QoL after operation .

 

Results: Totally, 45 pancreatic cancer patients participated in this study. Among patients, 64.6% (N=29) was recognized as cachexia syndrome. Patients with cachexia syndrome had more percentage to accept chemotherapy (χ2=9.504; p=.002), suffer from fistula after operation (χ2=5.237; p=.022), and had higher level of fatigue intensity (t= -2.889; p=.06) and duration (t=-2.363; p=.023) than those with non-cachexia syndrome . In the GEE analysis, the patients with higher level of symptom distress had lower level of QoL (β = -.323, p < .0001) after control the significant different factors at baseline between the two groups.

 

Conclusions: This study found that cachexia syndrome wasn’t a significant associated factor with QoL. In additionsymptom distress was the significant factor affecting longitudinal QoL in pancreatic cancer patients. Therefore, healthcare providers should pay more attention and assist pancreatic cancer patients to manage symptom distress since they diagnosed to increase the level of QoL.

Keywords:
cachexia syndrome; quality of life; symptom distress
Repository Posting Date:
22-Jun-2017
Date of Publication:
22-Jun-2017
Other Identifiers:
INRC17PST696
Conference Date:
2017
Conference Name:
28th International Nursing Research Congress
Conference Host:
Sigma Theta Tau International
Conference Location:
Dublin, Ireland
Description:
Event Theme: Influencing Global Health Through the Advancement of Nursing Scholarship

Full metadata record

DC FieldValue Language
dc.language.isoen_USen
dc.type.categoryFull-texten
dc.formatText-based Documenten
dc.typePosteren
dc.evidence.levelN/Aen
dc.research.approachN/Aen
dc.titleAssociation Among Cachexia Syndrome, Symptom Distress, and Quality of Life in Pancreatic Cancer Patientsen_US
dc.contributor.authorChou, Yun-Jenen
dc.contributor.authorShun, Shiow-Chingen
dc.contributor.departmentNon-memberen
dc.author.detailsYun-Jen Chou, MS, RN, Professional Experience: 2007-2009 Clinical nurses, Taipei Veterans General Hospital, Taipei, Taiwan. 2012-2017 Research Assistant, Department of Nursing, National Taiwan University College of Medicine, Taipei, Taiwan. 5 presentations at scientific meetings. Author Summary: Yun-Jen Chou is a doctoral student and research assistant in Nursing at the National Taiwan University. Also, she had been a clinical nurse for two years.en
dc.identifier.urihttp://hdl.handle.net/10755/621576-
dc.description.abstract<p><strong>Background: </strong><span>Cachexia syndrome is common in pancreatic cancer patients, and it will increase the mortality rate and decrease quality of life (QoL). However, there is no study with longitudinal design to explore the relationship among cachexia syndrome, symptom distress and QoL.</span><strong> </strong><span>Therefore, this study was to explore if the cachexia syndrome pre-operation was the significant factors to predict the longitudinal QoL after operation .</span></p> <p><strong> </strong></p> <p><strong>Methods: </strong>A longitudinal design was used in this study, and the data collected at 1~2 weeks before operation (T0), 2 months (T1), 3 months (T2), and 6 months (T3) after operation. Patients who scheduled to operate were recruited from surgery clinics at a medical center in Taipei. A structured questionnaire with Fatigue Symptom Inventory, Symptom Severity Scale, and Functional Assessment of Cancer Therapy-General Scale were used to collect patients’ fatigue, symptom distress and QoL, respectively. In addition, the questionnaire included patients’ demographic and clinical characteristic. In this study, cachexia syndrome was defined as patients’ total body weight loss > 5% over the past 6 months. The generalized estimating equation (GEE) was used to examine the significant associated factors with QoL after operation .</p> <p><strong> </strong></p> <p><strong>Results: </strong>Totally, 45 pancreatic cancer patients participated in this study. Among patients, 64.6% (N=29) was recognized as cachexia syndrome. Patients with cachexia syndrome had more percentage to accept chemotherapy (χ<sup>2</sup>=9.504; p=.002), suffer from fistula after operation (χ<sup>2</sup>=5.237; p=.022), and had higher level of fatigue intensity (t= -2.889; p=.06) and duration (t=-2.363; p=.023) than those with non-cachexia syndrome . In the GEE analysis, the patients with higher level of symptom distress had lower level of QoL (β = -.323, p < .0001) after control the significant different factors at baseline between the two groups.</p> <p><strong> </strong></p> <p><strong>Conclusions: </strong>This<strong> </strong>study<strong> </strong>found that cachexia syndrome wasn’t a significant associated factor with QoL.<strong> </strong>In addition<strong>, </strong>symptom distress was the significant factor affecting longitudinal QoL in pancreatic cancer patients. Therefore, healthcare providers should pay more attention and assist pancreatic cancer patients to manage symptom distress since they diagnosed to increase the level of QoL.</p>en
dc.subjectcachexia syndromeen
dc.subjectquality of lifeen
dc.subjectsymptom distressen
dc.date.available2017-06-22T14:40:38Z-
dc.date.issued2017-06-22-
dc.date.accessioned2017-06-22T14:40:38Z-
dc.conference.date2017en
dc.conference.name28th International Nursing Research Congressen
dc.conference.hostSigma Theta Tau Internationalen
dc.conference.locationDublin, Irelanden
dc.descriptionEvent Theme: Influencing Global Health Through the Advancement of Nursing Scholarshipen
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