Exploring the Relationship Between Docetaxel-Induced Peripheral Neuropathy and Quality of Life in Breast Cancer Survivors

2.50
Hdl Handle:
http://hdl.handle.net/10755/621927
Category:
Full-text
Format:
Text-based Document
Type:
Poster
Level of Evidence:
N/A
Research Approach:
N/A
Title:
Exploring the Relationship Between Docetaxel-Induced Peripheral Neuropathy and Quality of Life in Breast Cancer Survivors
Author(s):
Wang, Ya-Jung; Jheng, You-Wun; Wu, Chih-Jung
Lead Author STTI Affiliation:
Non-member
Author Details:
Ya-Jung Wang, PhD, RN, Professional Experience: 1995-1999 & 2001-2003 --Registered Nurse, National Taiwan University Hospital, Taipei, Taiwan 2012-present -- Assistant Professor, School of Nursing, National Yang-Ming University, Taipei, Taiwan 2010-2012 -- Assistant Professor, School of Nursing, China Medical University, Taichung, Taiwan Author Summary: Ya-Jung Wang is an assistant professor at Department of Nursing, National Yang-Ming University. She has devoted herself to cancer care for more than 10 years. Her research focus is on symptom management and interventions to deal with symptoms in women with breast cancer.
Abstract:

Purpose:  Docetaxel is benefit breast cancer survival demonstrated by numerous randomized trials. Docetaxel-induced peripheral neuropathy (DIPN) is one of side effects which is not easy to be aware and negatively influences women’s physical, psychological, social status and quality of life (QOL). There are many studies to survey the phenomenon of peripheral neuropathy in other countries, but it’s no study investigating its impact on Taiwanese women with breast cancer. The primary purpose of this study was to investigate the distribution and relationship among peripheral neuropathy and QOL in women with breast cancer after docetaxel treatment.

 

Methods:  This study utilized a cross-sectional study design and purposive sampling. Women with breast cancer received at least one treatment with docetaxel were recruited in this study from a medical center in northern Taiwan. Instruments included Patient Neurotoxicity Questionnaire, Total Neuropathy Score-clinical version, and Functional Assessment for Cancer Treatment-Breast and Taxane. The data were analyzed utilizing mean, standard deviation, frequency, percentage, independent-samples t test, one-way ANOVA, Chi-square test, and Pearson correlation.

Results:  The average age of 111 subjects was 50.78 years. The TIPN subjective measure found sensory and motor symptoms were 67.6% and 62.2%, respectively. Nearly half of the participants were with slight symptoms but only 4.5 to 7.2% of them were with a severe degree. The objective method indicated that 82.9% had peripheral neuropathy. Moreover, two of the most common symptoms were the deterioration of sensation on pinprick and vibration tests. PNQ sensory and motor scores were significantly higher in patients are undergoing docetaxel therapy compared to therapy has been completed. Women were keep exercise more than three times a week who got TNSc higher scores. There was a positive correlation between subjective and objective DIPN (rho=0.495, p<0.001), a negative correlation between subjective DIPN and quality of life (rho=-0.552, p=0.001), and then a negative correlation between objective DIPN and quality of life (rho=-0.407, p<0.001).

Conclusion:  Women with breast cancer after docetaxel treatment induced peripheral neuropathy negatively affected QOL. Oncology nurses are expected to have skills utilizing the TIPN subjective and objective tools to early detect and timely manage the DIPN. Therefore, the quality of life in this population is able to be advanced.

Keywords:
breast cancer; docetaxel-induced peripheral neuropathy; quality of life
Repository Posting Date:
19-Jul-2017
Date of Publication:
19-Jul-2017
Other Identifiers:
INRC17PST105
Conference Date:
2017
Conference Name:
28th International Nursing Research Congress
Conference Host:
Sigma Theta Tau International
Conference Location:
Dublin, Ireland
Description:
Event Theme: Influencing Global Health Through the Advancement of Nursing Scholarship

Full metadata record

DC FieldValue Language
dc.language.isoen_USen
dc.type.categoryFull-texten
dc.formatText-based Documenten
dc.typePosteren
dc.evidence.levelN/Aen
dc.research.approachN/Aen
dc.titleExploring the Relationship Between Docetaxel-Induced Peripheral Neuropathy and Quality of Life in Breast Cancer Survivorsen_US
dc.contributor.authorWang, Ya-Jungen
dc.contributor.authorJheng, You-Wunen
dc.contributor.authorWu, Chih-Jungen
dc.contributor.departmentNon-memberen
dc.author.detailsYa-Jung Wang, PhD, RN, Professional Experience: 1995-1999 & 2001-2003 --Registered Nurse, National Taiwan University Hospital, Taipei, Taiwan 2012-present -- Assistant Professor, School of Nursing, National Yang-Ming University, Taipei, Taiwan 2010-2012 -- Assistant Professor, School of Nursing, China Medical University, Taichung, Taiwan Author Summary: Ya-Jung Wang is an assistant professor at Department of Nursing, National Yang-Ming University. She has devoted herself to cancer care for more than 10 years. Her research focus is on symptom management and interventions to deal with symptoms in women with breast cancer.en
dc.identifier.urihttp://hdl.handle.net/10755/621927-
dc.description.abstract<p><strong><strong>Purpose: </strong></strong><span> Docetaxel is benefit breast cancer survival demonstrated by numerous randomized trials. Docetaxel-induced peripheral neuropathy (DIPN) is one of side effects which is not easy to be aware and negatively influences women’s physical, psychological, social status and quality of life (QOL). There are many studies to survey the phenomenon of peripheral neuropathy in other countries, but it’s no study investigating its impact on Taiwanese women with breast cancer. The primary purpose of this study was to investigate the distribution and relationship among peripheral neuropathy and QOL in women with breast cancer after docetaxel treatment.</span></p> <p> </p> <p><strong><strong>Methods: </strong> </strong>This study utilized a cross-sectional study design and purposive sampling. Women with breast cancer received at least one treatment with docetaxel were recruited in this study from a medical center in northern Taiwan. Instruments included Patient Neurotoxicity Questionnaire, Total Neuropathy Score-clinical version, and Functional Assessment for Cancer Treatment-Breast and Taxane. The data were analyzed utilizing mean, standard deviation, frequency, percentage, independent-samples t test, one-way ANOVA, Chi-square test, and Pearson correlation.</p> <p><strong><strong>Results: </strong> </strong>The average age of 111 subjects was 50.78 years. The TIPN subjective measure found sensory and motor symptoms were 67.6% and 62.2%, respectively. Nearly half of the participants were with slight symptoms but only 4.5 to 7.2% of them were with a severe degree. The objective method indicated that 82.9% had peripheral neuropathy. Moreover, two of the most common symptoms were the deterioration of sensation on pinprick and vibration tests. PNQ sensory and motor scores were significantly higher in patients are undergoing docetaxel therapy compared to therapy has been completed. Women were keep exercise more than three times a week who got TNSc higher scores. There was a positive correlation between subjective and objective DIPN (rho=0.495, p<0.001), a negative correlation between subjective DIPN and quality of life (rho=-0.552, p=0.001), and then a negative correlation between objective DIPN and quality of life (rho=-0.407, p<0.001).</p> <p><strong><strong>Conclusion: </strong> </strong>Women with breast cancer after docetaxel treatment induced peripheral neuropathy negatively affected QOL. Oncology nurses are expected to have skills utilizing the TIPN subjective and objective tools to early detect and timely manage the DIPN. Therefore, the quality of life in this population is able to be advanced.</p>en
dc.subjectbreast canceren
dc.subjectdocetaxel-induced peripheral neuropathyen
dc.subjectquality of lifeen
dc.date.available2017-07-19T14:41:06Z-
dc.date.issued2017-07-19-
dc.date.accessioned2017-07-19T14:41:06Z-
dc.conference.date2017en
dc.conference.name28th International Nursing Research Congressen
dc.conference.hostSigma Theta Tau Internationalen
dc.conference.locationDublin, Irelanden
dc.descriptionEvent Theme: Influencing Global Health Through the Advancement of Nursing Scholarshipen
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