Age appropriate treatment of drug-resistant tuberculosis in South Africa

2.50
Hdl Handle:
http://hdl.handle.net/10755/621960
Category:
Full-text
Format:
Text-based Document
Type:
Dissertation
Level of Evidence:
Cross-Sectional Study
Research Approach:
Quantitative Research
Title:
Age appropriate treatment of drug-resistant tuberculosis in South Africa
Author(s):
Sullivan, Brittney Jayne
Lead Author STTI Affiliation:
Beta Epsilon
Advisors:
Humphreys, Janice; Bettger, Janet Prvu; Silva, Susan G.; Cunningham, Coleen K.; Farley, Jason E.
Author Details:
Brittney Jayne Sullivan, PhD, MS, RN, CPNP, brittney.sullivan@duke.edu; Janet Prvu Bettger, ScD, janet.bettger@duke.edu; Susan G. Silva, PhD, susan.silva@duke.edu; Janice Humphreys, PhD, RN, FAAN, janice.humphreys@duke.edu; Coleen K. Cunningham, MD, coleen.cunningham@duke.edu; Jason E. Farley, PhD, MPH, ANP-BC, FAAN, AACRN, jfarley1@jhu.edu
Abstract:

The purpose of this study was to describe the time from DR-TB diagnosis to treatment initiation for people in South Africa with DR-TB with and without HIV and to evaluate the influence of age on the timing of treatment initiation after controlling for patient and health system characteristics. It was hypothesized that younger patients would have a greater number of days from DR-TB diagnosis to DR-TB treatment initiation. Additionally, we address the knowledge gaps pertaining to prescription of guideline-based treatment for DR-TB at treatment initiation and the influence of individual and health system factors on prescribed treatment for youth and adults with DR-TB. We hypothesized that younger patients would be less likely to be prescribed guideline recommended treatment (medication type, dose and frequency) for DR-TB.

Keywords:
Tuberculosis, Multidrug Resistant prevention and control; Global Health
CINAHL Headings:
Tuberculosis, Multidrug-Resistant--Drug Therapy; Tuberculosis, Multidrug-Resistant -- Prevention and Control; Tuberculosis, Multidrug-Resistant--In Infancy and Childhood; Young Adult; South Africa
Repository Posting Date:
19-Jul-2017
Date of Publication:
19-Jul-2017
Sponsors:
Sigma Theta Tau International
Note:
The Sigma Theta Tau International grant application that funded this research, in whole or in part, was completed by the applicant and peer-reviewed prior to the award of the STTI grant. No further peer-review has taken place upon the completion of the STTI grant final report and its appearance in this repository. This document has been accepted by the indicated university or college in partial fulfillment of the requirements for the specified degree.
Grantor:
Duke University
Degree:
PhD
Degree Year:
2017

Full metadata record

DC FieldValue Language
dc.language.isoen_USen
dc.type.categoryFull-texten
dc.formatText-based Documenten
dc.typeDissertationen
dc.evidence.levelCross-Sectional Studyen
dc.research.approachQuantitative Researchen
dc.titleAge appropriate treatment of drug-resistant tuberculosis in South Africaen_US
dc.contributor.authorSullivan, Brittney Jayneen
dc.contributor.departmentBeta Epsilonen
dc.contributor.advisorHumphreys, Janiceen
dc.contributor.advisorBettger, Janet Prvuen
dc.contributor.advisorSilva, Susan G.en
dc.contributor.advisorCunningham, Coleen K.en
dc.contributor.advisorFarley, Jason E.en
dc.author.detailsBrittney Jayne Sullivan, PhD, MS, RN, CPNP, brittney.sullivan@duke.edu; Janet Prvu Bettger, ScD, janet.bettger@duke.edu; Susan G. Silva, PhD, susan.silva@duke.edu; Janice Humphreys, PhD, RN, FAAN, janice.humphreys@duke.edu; Coleen K. Cunningham, MD, coleen.cunningham@duke.edu; Jason E. Farley, PhD, MPH, ANP-BC, FAAN, AACRN, jfarley1@jhu.eduen
dc.identifier.urihttp://hdl.handle.net/10755/621960-
dc.description.abstract<p>The purpose of this study was to describe the time from DR-TB diagnosis to treatment initiation for people in South Africa with DR-TB with and without HIV and to evaluate the influence of age on the timing of treatment initiation after controlling for patient and health system characteristics. It was hypothesized that younger patients would have a greater number of days from DR-TB diagnosis to DR-TB treatment initiation. Additionally, we address the knowledge gaps pertaining to prescription of guideline-based treatment for DR-TB at treatment initiation and the influence of individual and health system factors on prescribed treatment for youth and adults with DR-TB. We hypothesized that younger patients would be less likely to be prescribed guideline recommended treatment (medication type, dose and frequency) for DR-TB.</p>en
dc.subjectTuberculosis, Multidrug Resistant prevention and controlen
dc.subjectGlobal Healthen
dc.subject.cinahlTuberculosis, Multidrug-Resistant--Drug Therapyen
dc.subject.cinahlTuberculosis, Multidrug-Resistant -- Prevention and Controlen
dc.subject.cinahlTuberculosis, Multidrug-Resistant--In Infancy and Childhooden
dc.subject.cinahlYoung Adulten
dc.subject.cinahlSouth Africaen
dc.date.available2017-07-19T20:52:51Z-
dc.date.issued2017-07-19-
dc.date.accessioned2017-07-19T20:52:51Z-
dc.description.sponsorshipSigma Theta Tau Internationalen
dc.description.noteThe Sigma Theta Tau International grant application that funded this research, in whole or in part, was completed by the applicant and peer-reviewed prior to the award of the STTI grant. No further peer-review has taken place upon the completion of the STTI grant final report and its appearance in this repository. This document has been accepted by the indicated university or college in partial fulfillment of the requirements for the specified degree.-
thesis.degree.grantorDuke Universityen
thesis.degree.levelPhDen
thesis.degree.year2017-
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