2.50
Hdl Handle:
http://hdl.handle.net/10755/622039
Category:
Full-text
Format:
Text-based Document
Type:
Poster
Level of Evidence:
N/A
Research Approach:
N/A
Title:
The Risk Factors Affecting Survival in Colorectal Cancer in Taiwan
Author(s):
Wu, Shu-Fen; Lee, Chao-Hsien; Cheng, Shu-Chen; Tung, Hong-Yi; Shang, Shih-Chang; Ching, Ching-Yun
Lead Author STTI Affiliation:
Lambda Beta-at-Large
Author Details:
Shu-Fen Wu, MSN, RN, Professional Experience: 1984-86 -- RN, Department of Nursing, Mackay Memorial Hospital, Taipei, Taiwan 1992-99 -- RN, Department of Anesthesiology, Chang Gung Medical Foundation Hospital, Taipei, Taiwan 2002-2016 -- RN, Department of Anesthesiology & Nursing, Yuan's General Hospital, Kaohsiung, Taiwan 2014-16 -- Adjunct Lecture, Department of Health Business Administration, Meiho University, Pingtung, Taiwan 2016 -- RN, Department of Anesthesiology, E-Da Dachang Hospital, Kaohsiung, Taiwan 2016 -- Adjunct Lecture, Department of Nursing, I-Shou University, Kaohsiung, Taiwan Author or coauthor of 20 publications primarily relating to cancer nursing and research. Author Summary: Shu-Fen Wu obtained her master's degree from the school of nursing management, I-Shou University in 2013. She is currently director of nursing anesthesia E-Dachang hospital, and adjunct lecture teacher of health business administration I-Shou University. Her current research focuses on clinical and cancer nursing.
Abstract:

BackgroundColorectal cancer (CRC) is the second and third most commonly diagnosed cancer type in females and males, respectively, representing almost 10% of the global cancer incidence. The incidence of colorectal cancer (CRC) in Taiwan is rising. Cancer survival is an indicator of the overall effectiveness of health services in the management of patients. In this study, we sought to determine the five-year survival rate of patients diagnosed with CRC and to determine factors affecting survival. Methods: In this study, we conducted a single-center, retrospective cohort study to estimate the survival outcome of patients diagnosed with colorectal carcinoma at medical center hospital in North Taiwan between 2007 and 2013. Data were extracted from medical records and the cancer database by trained data collectors. In all, 869 patients with CRC were included in this study. Survival analysis was performed using Kaplan-Meier curves, and differences between the curves were analyzed using the log-rank test. Cox proportional hazards regression models were used to analyze survival by each variable. Results: We retrospectively evaluated 869 CRC patients from 2007 to 2013. Of these, 454 subjects were males (52.24%), and the remaining (47.76%) were females. The mean and median ages at diagnosis were 63.70 years (SD = 0.45) and 64 years (range, 17-97), respectively. The mean survival time was 71.27±1.27 months. CRC-specific survival was 95.3%, 79.4% and 68.7% at 1, 3 and 5 years. The five-year survival rate for patients with stage I, II, III and IV disease was 91.20%, 82.20%, 63.20% and 21.70%. The Cox forward stepwise regression model revealed a significant potentially curable disease and risk of CRC death. The following factors were associated with a relative excess hazard for death: age ≥ 65 years (HR = 2.36, 95% CI: 1.76 - 3.17, P < 0.001); high grade of pathological differentiation (HR = 1.84, 95% CI: 1.27 - 2.66, P = 0.001); perineural nerve invasion (HR = 2.90, 95% CI: 2.03 - 4.14, < 0.001); metastasis to distant organs (HR = 2.78, 95% CI: 2.00 - 3.87, < 0.001); intestinal obstruction (HR = 1.38, 95% CI: 1.04 - 1.84, = 0.026); and multiple regional lymph node metastases (HR = 1.81, 95% CI: 0.28 - 2.57, P = 0.001). Conclusion: Long-term survival from colorectal cancer remains good with 68.7% of patients being a live five years after their diagnosis. In this study, we found that perineural nerve invasion, distant metastasis, age, pathological differentiation grade, obstruction and regional lymph node metastasis are independent predictors of the survival and prognosis of patients with CRC. Perineural nerve invasion and distant metastasis appeared to be important prognostic factors affecting the entire patient cohort, and the earlier detection of CRC would improve patient survival. One limitation of this study was the small sample size; in addition, the findings were generated using data from a single medical center hospital in North Taiwan. Thus, the results of some survival comparisons were not significant. These limitations should be considered when applying these results to other districts in Taiwan that may have demographic differences. Furthermore, multicenter studies should be conducted to merge patient datasets for further research in Taiwan.

Keywords:
risk factors; colorectal cancer; survival
Repository Posting Date:
21-Jul-2017
Date of Publication:
21-Jul-2017
Other Identifiers:
INRC17PST347
Conference Date:
2017
Conference Name:
28th International Nursing Research Congress
Conference Host:
Sigma Theta Tau International
Conference Location:
Dublin, Ireland
Description:
Event Theme: Influencing Global Health Through the Advancement of Nursing Scholarship

Full metadata record

DC FieldValue Language
dc.language.isoen_USen
dc.type.categoryFull-texten
dc.formatText-based Documenten
dc.typePosteren
dc.evidence.levelN/Aen
dc.research.approachN/Aen
dc.titleThe Risk Factors Affecting Survival in Colorectal Cancer in Taiwanen_US
dc.contributor.authorWu, Shu-Fenen
dc.contributor.authorLee, Chao-Hsienen
dc.contributor.authorCheng, Shu-Chenen
dc.contributor.authorTung, Hong-Yien
dc.contributor.authorShang, Shih-Changen
dc.contributor.authorChing, Ching-Yunen
dc.contributor.departmentLambda Beta-at-Largeen
dc.author.detailsShu-Fen Wu, MSN, RN, Professional Experience: 1984-86 -- RN, Department of Nursing, Mackay Memorial Hospital, Taipei, Taiwan 1992-99 -- RN, Department of Anesthesiology, Chang Gung Medical Foundation Hospital, Taipei, Taiwan 2002-2016 -- RN, Department of Anesthesiology & Nursing, Yuan's General Hospital, Kaohsiung, Taiwan 2014-16 -- Adjunct Lecture, Department of Health Business Administration, Meiho University, Pingtung, Taiwan 2016 -- RN, Department of Anesthesiology, E-Da Dachang Hospital, Kaohsiung, Taiwan 2016 -- Adjunct Lecture, Department of Nursing, I-Shou University, Kaohsiung, Taiwan Author or coauthor of 20 publications primarily relating to cancer nursing and research. Author Summary: Shu-Fen Wu obtained her master's degree from the school of nursing management, I-Shou University in 2013. She is currently director of nursing anesthesia E-Dachang hospital, and adjunct lecture teacher of health business administration I-Shou University. Her current research focuses on clinical and cancer nursing.en
dc.identifier.urihttp://hdl.handle.net/10755/622039-
dc.description.abstract<p><strong>Background</strong><strong>: </strong><span>Colorectal cancer (CRC) is the second and third most commonly diagnosed cancer type in females and males, respectively, representing almost 10% of the global cancer incidence. The incidence of colorectal cancer (CRC) in Taiwan is rising. Cancer survival is an indicator of the overall effectiveness of health services in the management of patients. In this study, we sought to determine the five-year survival rate of patients diagnosed with CRC and to determine factors affecting survival. </span><strong>M</strong><strong>ethods:</strong><span> In this study, we conducted a single-center, retrospective cohort study to estimate the survival outcome of patients diagnosed with colorectal carcinoma at medical center hospital in North Taiwan between 2007 and 2013. Data were extracted from medical records and the cancer database by trained data collectors. In all, 869 patients with CRC were included in this study. Survival analysis was performed using Kaplan-Meier curves, and differences between the curves were analyzed using the log-rank test. Cox proportional hazards regression models were used to analyze survival by each variable. </span><strong>Results: </strong><span>We retrospectively evaluated 869 CRC patients from 2007 to 2013. Of these, 454 subjects were males (52.24%), and the remaining (47.76%) were females. The mean and median ages at diagnosis were 63.70 years (SD</span><em> </em><span>= 0.45) and 64 years (range, 17-97), respectively. The mean survival time was 71.27±1.27 months. CRC-specific survival was 95.3%, 79.4% and 68.7% at 1, 3 and 5 years. The five-year survival rate for patients with stage I, II, III and IV disease was 91.20%, 82.20%, 63.20% and 21.70%. The Cox forward stepwise regression model revealed a significant potentially curable disease and risk of CRC death. The following factors were associated with a relative excess hazard for death: age ≥ 65 years (HR = 2.36, 95% CI: 1.76 - 3.17, </span><em>P</em><span> < 0.001); high grade of pathological differentiation (HR = 1.84, 95% CI: 1.27 - 2.66, </span><em>P</em><span> = 0.001); perineural nerve invasion (HR = 2.90, 95% CI: 2.03 - 4.14, </span><em>P </em><span>< 0.001); metastasis to distant organs (HR = 2.78, 95% CI: 2.00 - 3.87, </span><em>P </em><span>< 0.001); intestinal obstruction (HR = 1.38, 95% CI: 1.04 - 1.84, </span><em>P </em><span>= 0.026); and multiple regional lymph node metastases (HR = 1.81, 95% CI: 0.28 - 2.57, </span><em>P</em><span> = 0.001). </span><strong>Conclusion: </strong><span>Long-term survival from colorectal cancer remains good with 68.7% of patients being a live five years after their diagnosis. In this study, we found that perineural nerve invasion, distant metastasis, age, pathological differentiation grade, obstruction and regional lymph node metastasis are independent predictors of the survival and prognosis of patients with CRC. Perineural nerve invasion and distant metastasis appeared to be important prognostic factors affecting the entire patient cohort, and the earlier detection of CRC would improve patient survival. One limitation of this study was the small sample size; in addition, the findings were generated using data from a single medical center hospital in North Taiwan. Thus, the results of some survival comparisons were not significant. These limitations should be considered when applying these results to other districts in Taiwan that may have demographic differences. Furthermore, multicenter studies should be conducted to merge patient datasets for further research in Taiwan.</span></p>en
dc.subjectrisk factorsen
dc.subjectcolorectal canceren
dc.subjectsurvivalen
dc.date.available2017-07-21T21:08:07Z-
dc.date.issued2017-07-21-
dc.date.accessioned2017-07-21T21:08:07Z-
dc.conference.date2017en
dc.conference.name28th International Nursing Research Congressen
dc.conference.hostSigma Theta Tau Internationalen
dc.conference.locationDublin, Irelanden
dc.descriptionEvent Theme: Influencing Global Health Through the Advancement of Nursing Scholarshipen
All Items in this repository are protected by copyright, with all rights reserved, unless otherwise indicated.